Oncology: Class, Target, Resp

Mechlorethamine, Melphalan, Ifosfamide, Cyclophosphamide, Chlorambucil Class?

Nitrogen Mustard, DNA Damaging Agent

Mechlorethamine, Melphalan, Ifosfamide, Cyclophosphamide, Chlorambucil Target?

Causes intra- and inter-strand cross-bridges

Mechlorethamine, Melphalan, Ifosfamide, Cyclophosphamide, Chlorambucil Biochem Resp?

Inability of cells to separate double-helical DNA

Mechlorethamine, Melphalan, Ifosfamide, Cyclophosphamide, Chlorambucil Physiological Resp

Loss of proliferation and translation; Eventual apotosis

Carmustine, Streptozoxin Class?

Nitrosoureas, DNA Damaging Agent

Carmustine, Streptozoxin Target?

Causes intra- and inter-strand cross-bridges

Carmustine, Streptozoxin Biochem Resp

Inability of cells to separate double-helical DNA

Carmustine, Streptozoxin Physiological Resp

Loss of proliferation and translation; Eventual apotosis

Oxaliplatin, Carboplatin, Cisplatin Class?

Platinum Coordination Complex, DNA Damaging Agent

Oxaliplatin, Carboplatin, Cisplatin Target?

Causes intra- and inter-strand cross-bridges

Oxaliplatin, Carboplatin, Cisplatin Biochem Resp

Inability of cells to separate double-helical DNA

Oxaliplatin, Carboplatin, Cisplatin Physiological Resp

Loss of proliferation and translation; Eventual apotosis

Temozolomide, Dacarbazine Class?

Triazene, DNA Damaging Agent

Temozolomide, Dacarbazine Target?

Addition of methyl group to DNA bases (esp guanine)

Temozolomide, Dacarbazine Biochem Resp

Basepair mismatch (G w/ T, A w/ C)

Temozolomide, Dacarbazine Physiological Resp

Loss of DNA fidelity leads to loss of function

Daunorubicin, Doxorubicin, Idarubicin Class?

Anthracycline antibiotic, DNA Damaging Agent

Daunorubicin, Doxorubicin, Idarubicin Target?

Interclates into DNA and inhibits Topo II inducing ds and ss breaks

Daunorubicin, Doxorubicin, Idarubicin Biochem Resp?

Inability to replicate DNA or undergo transcription

Daunorubicin, Doxorubicin, Idarubicin Physiological Resp?

Halts DNA cell cycle progression; Loss of function; Apoptosis

Bleomycin, Mitomycin Class?

Anthracenedione antibiotics, DNA Damaging Agent

Bleomycin, Mitomycin Target?

Intercalated into DNA causes ds and ss breaks

Bleomycin, Mitomycin Biochem Resp

Inability to proliferate or synth proteins

Bleomycin, Mitomycin Physiological Resp?

Halts DNA cell cycle progression; Loss of function; Apotosis

Methotrexate Class?

Anti-metabolite, DNA Replication Inhibitor

Methotrexate Target?

Competitive inhibitor of dihydrofolate reductase

Methotrexate Biochem Resp?

Inability to activate DHF to THF

Methotrexate Physiological Resp?

Loss of immune cell proliferation

Capecitabine, Floxuridine Class?

Anti-metabolite, DNA Replication Inhibitor

Capecitabine, Floxuridine Target?

Inhibition of Thymidylate Synthase

Capecitabine, Floxuridine Biochem Resp?

Inability to convert dUMP to dTMP

Capecitabine, Floxuridine Physiological Resp?

Loss of proliferation

Cytarabine (araC) Class?

Anti-metabolite, DNA Replication Inhibitor

Cytarabine (araC) Target?

Prodrug incorporated into replicating DNA for inhibition of DNA pol

Cytarabine (araC) Biochem Resp?

Inability to synth new DNA

Cytarabine (araC) Physiological Resp?

Loss of proliferation

Mercaptopurine, Thioguanine/Tioguanine Class?

Anti-metabolite, DNA Replication Inhibitor

Mercaptopurine, Thioguanine/Tioguanine Target?

Prodrug incorporated into DNA inhibition DNA pol and de novo purine synth

Mercaptopurine, Thioguanine/Tioguanine Biochem Resp?

Inability of cells to synth new DNA or proteins

Mercaptopurine, Thioguanine/Tioguanine Physiological Resp?

Loss of proliferation and function

Cladribine Class?

Anti-metabolite, DNA Replication Inhibitor

Cladribine Target?

Prodrug inhibits DNA pol and induces DNA strand break

Cladribine Biochem Resp?

Inability of cells to synth new DNA strands or protein

Cladribine Physiological Resp?

Loss of proliferation and function; Apotosis

Gemcitabine, Fludarabine Class?

Anti-metabolite, DNA Replication Inhibitor

Gemcitabine, Fludarabine Target?

Prodruginhibits ribonucleotide reductase and DNA pol

Gemcitabine, Fludarabine Biochem Resp?

Cells unable to synth deoxyribonucleosides and DNA strands

Gemcitabine, Fludarabine Physiological Resp?

Loss of proliferation

Pentostatin Class?

Anti-metabolite, DNA Replication Inhibitor

Pentostatin Target?

Inhibition of adenosine deaminase leading to inhibition of ribonuclease reductase

Pentostatin Biochem Resp

Inability of cells to synth deoxyribonucleosides

Pentostatin Physiological Resp

Loss of proliferation

Bortezomib Class?

Anti-metabolite, DNA Replication Inhibitor

Bortezomib Target?

Inhibition of 26S proteasome

Bortezomib Biochem Resp

Inability to degrade pro-apoptotic proteins

Bortezomib Physiological Resp

Induction of apoptosis

Irinotecan, Topotecan Class?

Topoisomerase I inhibitor, DNA Replication Inhibitor

Irinotecan, Topotecan Target?

Inhibition of Topoisomerase I

Irinotecan, Topotecan Biochem Resp?

Cells unable to unwind DNA

Irinotecan, Topotecan Physiological Resp

Loss of proliferation and protein synth

Etoposide, Teniposide Class?

Topoisomerase II inhibitor, DNA Replication Inhibitor

Etoposide, Teniposide Target?

Inhibition of Topoisomerase II

Etoposide, Teniposide Biochem Resp

Cells unable to unwind DNA

Etoposide, Teniposide Physiological Resp

Loss of proliferation and protein synth

Vinblastine, Vincristine Class?

Mitotic inhibitor

Vinblastine, Vincristine Target

Inhibits polymerization of tubulin into microtubules

Vinblastine, Vincristine Biochem Resp

Cell is unable to separate components equally

Vinblastine, Vincristine Physiological Resp

Inhibition of proliferation

Paclitaxel, Docetaxel Class?

Mitotic Inhibitor

Paclitaxel, Docetaxel Target

Inhibits de-polymerization of microtubules into tubulin

Paclitaxel, Docetaxel biochem resp

Inability of cells to pull components apart during mitosis

Paclitaxel, Docetaxel Physiological resp

Inhibition of proliferation

Tamoxifen, Toremifene Class?

Estrogen Receptor Antagonist

Tamoxifen, Toremifene Biochem Resp

Inability of cells to transcribe genes under control of estrogen receptor

Tamoxifen, Toremifene Physiological Resp

Inhibition of proliferation and immune avoidance

Anastrozole, Exemestane, Letrozole Class

Hormone Receptor Antagonist

Anastrozole, Exemestane, Letrozole Target

Inhibition of aromatase

Anastrozole, Exemestane, Letrozole Biochem Resp

Inability of cells to produce estrogen from precursors

Anastrozole, Exemestane, Letrozole Physiological Resp

Inhibition of proliferation and immune avoidance

Nilutamide, Flutamide Class

Androgen Receptor Antagonist

Nilutamide, Flutamide Biochem Resp

Cells unable to transcribe genes under control of androgen receptor

Nilutamide, Flutamide Physiological Resp

Inhibition of proliferation and immune avoidance

Geftinib, Erlotinib Class

Protein Tyrosine Kinase Inhibitor

Geftinib, Erlotinib Target

Inhibition of Epidermal Growth Factor Receptor (EGFR)

Geftinib, Erlotinib Biochem Resp

Inability to begin Growth Factor Signal Cascade

Geftinib, Erlotinib Physiological Resp

Inability of cancer to proliferate and metastasize; Apoptosis

Imatinib Class

Protein Tyrosine Kinase Inhibitor

Imatinib Target

Inhibition of bcr-abl chimeric tyrosine kinase

Imatinib Biochem Resp

Inability to begin Growth Factor Signal Cascade

Imatinib Physiological Resp

Inability of cancer to proliferate and metastasize; Apoptosis

Antigen Antagonist Class?

Nake AB, Immune System Modulator

Antigen Antagonist Target

Inhibition of over-expressed antigen (oncogene) on cell surface

Trastuzumab Target

HER2/neu epidermal growth factor receptor

Trastuzumab Spectra

Metastatic breast cancer

Bevacizumab Target

Vascular-endothelial growth factor

Bevacizumab Spectra

Metastatic colorectal cancer

Cetuximab Target

Epithelial growth factor receptor

Cetuximab Spectra

Metastatic colorectal cancer

Antigen Antagonist Biochem Resp

Inability to begin Growth Factor Signal Cascade

Antigen Antagonist Physiological Resp

Inability of cancer to proliferate and metastasize; Apoptosis