[mtap 2] blood bank: other blood groups
Studied by 0 people
Learn
Practice Test
Spaced Repetition
Match
Flashcards1/82
There's no tags or description
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced |
|---|
No study sessions yet.
83 Terms
Lewis system
Which blood group system is found in secretions and plasma instead of on RBCs?
Le and Se genes
Which genes influence Lewis phenotype?
Le(a–b+)
What is the most common Lewis phenotype in secretors?
Anti-Lea
What antibody is naturally occurring in Lewis system?
No
Is anti-Lea clinically significant?
Autoanti-P
What antibody is associated with paroxysmal cold hemoglobinuria?
P system
What system does autoanti-P belong to?
p phenotype
Which P phenotype lacks all P antigens?
Donath-Landsteiner test
What confirms the presence of autoanti-P?
Anti-P1
What antibody is enhanced by pigeon egg fluid and hydatid cyst?
I
What I antigen is found in adults?
i
What I antigen is found in newborns?
Mycoplasma pneumoniae
What infection is associated with anti-I?
Epstein-Barr virus
What infection is associated with anti-i?
Cold-reactive
What kind of antibody is anti-I?
Anti-M and Anti-N
Which MNS antibodies are usually IgM?
Anti-S and Anti-s
Which MNS antibodies are clinically significant IgG?
Anti-M
Which MNS antibodies exhibit dosage?
Ficin or papain
Which enzyme destroys MNS antigens?
K (K1)
What is the most immunogenic Kell antigen?
IgG
What class are most Kell antibodies?
Suppresses fetal erythropoiesis
What does anti-K do in pregnancy?
McLeod syndrome
What syndrome is associated with lack of Kx antigen?
Anti-K
What Kell antibodies are clinically significant?
Anti-Jka and Anti-Jkb
What Kidd antibodies are most significant?
Delayed HTR
What type of hemolytic reaction do Kidd antibodies cause?
Yes
Do Kidd antibodies show dosage?
Anti-Jk3
What Kidd antibody reacts with all Kidd-positive cells?
Fy(a–b–)
What Duffy phenotype is resistant to malaria?
Plasmodium vivax
What Plasmodium species is blocked by Duffy-null phenotype?
Anti-Fya and Anti-Fyb
Which Duffy antibodies are significant?
IgG
What class are Duffy antibodies?
Yes
Are Duffy antigens enzyme-sensitive?
Anti-Lua
What Lutheran antibody is naturally occurring?
Anti-Lub
Which Lutheran antibody is clinically significant?
Anti-Lu3
What Lutheran antibody reacts with all Lutheran-positive cells?
Lu(a–b–)
What Lutheran phenotype makes anti-Lu3?
Resistant to enzyme treatment
What enzyme effect do Lutheran antigens have?
Dia
What Diego antigen is more common in Asians?
Anti-Wra
What Diego antibody is naturally occurring?
Anti-Wrb
What Diego antibody is linked to autoimmune hemolytic anemia?
Dib
What Diego antigen is high frequency?
Band 3
What protein carries Diego antigens?
Aquaporin-1
What protein carries Colton antigens?
Coa and Cob
What are the two main Colton antigens?
Anti-Co3
What Colton antibody reacts with all Coa and Cob cells?
Anti-Co3
What antibody may cause renal symptoms in Colton-null individuals?
No
Are Colton antigens affected by enzymes?
Anti-M
Which antibodies are naturally occurring?
Anti-D
Which antibodies are typically immune (not naturally occurring)?
IgM antibodies (e.g.
Which antibodies react at cold temperatures?
IgG antibodies
Which antibodies react at body temp (37°C)?
Anti-M
Which antibodies show dosage effect?
Anti-Jka
Which antibodies are enhanced by enzyme treatment?
Anti-M
Which antibodies are destroyed by enzyme treatment?
Anti-D
Which antibodies can cause severe HDFN?
Anti-Jkb
Which antibodies can cause mild HDFN?
Anti-Jka
Which antibodies can cause delayed HTR?
Autoanti-P
What is the biphasic hemolysin in PCH?
Kx system
Which system is linked to McLeod syndrome?
Neurologic symptoms
What’s the effect of McLeod syndrome?
international society of blood transfusion - working party for red cell immunogenetics and blood group terminology
this maintains an official record of all currently recognized blood group systems
48
345
there are currently __ recognized blood group systems containing __ red cell antigens
international society of blood transfusion - working party for red cell immunogenetics and blood group terminology
they are developed to facilitate computer storage and retrieval of blood group information and to help standardize blood group system and antigen names
order of discovery
ISBT numbers are based on?
six-digit numbers
ISBT numbers are made up of?
system collection or series
the first three numbers of ISBT represent?
antigenic specificity
second three numbers of ISBT represent?
RBC phenotype
serologic tests determine only the?
genotype
is composed of the actual genes that an individual has inherited and can be determined only by family or DNA studies
system
consists of one or more antigens controlled at a single gene locus, or by two or more very closely links homologous genes with little or no observable recombination between them
collections
are antigens that have biochemical, serologic, or genetic relationship but do not meet the criteria for a system
series
not a system, not a collection; all remaining RBC antigens that are not associated with a system or a collection are characterized into the 700 series of low prevalence antigen of the 901 series of high prevalence antigens
antibodies
described by their antigen notation with the prefix anti- including a hyphen before the antigen symbol
007
ISBT number of Lewis system
plasma antigen
lewis antigen is also known as?
red cells and serum/plasma
lewis antigens are found both where?
extrinsic
is the lewis antigen intrinsic or extrinsic to RBCs?
tissue
lewis antigens are synthesized by ____ instead of the red cell
type 1 glycosphingolipid
because the lewis antigen is a _____, they are adsorbed in the RBC membrane
Lea and Leb
the two antigens of the lewis system
chromosome 19
the lewis gene is found on?
fucosyl transferase enzyme
the le gene codes for the production of?