Tripepi Exam 2

2) Which of the following pairs is mismatched?

RNA polymerase makes a molecule of RNA from an RNA template

10) Both normal and transient flora can become opportunistic pathogens.

true

5) Diseases that are referred to as emerging infectious diseases have only been discovered in the past fifty years.

false

33) Which of the following is NOT a predisposing factor of disease?

all answers

16) Which of the following is NOT a reservoir of infection?

none of the answers

10) When haptens attach to carrier molecules, an epitope forms on hapten which then can be bound to antibody.

false

35) The following events occur in cellular immunity, leading to a response from TH cells. What is the third step?

TH cells proliferate

20) The most abundant class of antibodies in serum is

IgG

3) What type of immunity results from recovery from mumps?

naturally acquired active immunity

42) PCR can be used to identify an unknown bacterium because

the primer is specific

29) Which of the following methods would be used to introduce the plasmid shown in Figure 9.5 into E. coli?

transformation

16) The restriction enzyme EcoRI recognizes the sequence G↓AATTC. Which of the following is TRUE of DNA after it is treated with EcoRI?

all of the DNA fragments will have single stranded regions ending in AA

2) How many pieces willEcoRI produce from the plasmid shown in Figure 9.1?

2

35) An enzyme that makes covalent bonds between the sugar of one nucleotide and the phosphate groups in another nucleotide in DNA is

DNA ligase

21) Refer to Table 8.2. If the sequence of amino acids encoded by a strand of DNA is

b) 3' AGACGTTTCAAT

6) Which of the following statements about bacteriocins is FALSE?

they cause food poisoning symptoms

38) The following steps occur during multiplication of herpesviruses. Which is the third step?

uncoating

25) The most conclusive evidence that viruses cause cancers is provided by

cancer following injection of cell free filtrates

how do all viruses differ from bacreria

viruses are not composed of cells

which of the following is not used as a criterion to classify viruses

biochemical tests

which of the following is not utilized to culture viruses

culture media

bacteriophages and animal viruses do not differ significantly which one of the following steps

biosynthesis

the definition of lysogen is

phage dna is incorporated into host cell

in figure 13.1 which structure is a complex virus

B

looks like a rocket with legs

the structures illustrated in figure 13.1 are composed of

capsomeres

11) A clear area against a confluent "lawn" of bacteria is called a

plaque

an infectious protein is a

prion

an envelope is acquired during which of the following steps

release

20) Which of the following statements is NOT true of lysogeny?

it causes lysis of host cells

an example of a latent viral infection is

cold sores

24) The mechanism whereby an enveloped virus leaves a host cell is called

budding

23) Assume you have isolated an unknown virus. This virus has a single, positive sense strand of RNA, and possesses an envelope. To which group does it most likely belong?

togavirus

22) A virus's ability to infect an animal cell depends primarily upon the

presence of receptor sites on the cell membrane

17) Which of the following would be the first step in biosynthesis of a virus with a - (minus) strand of RNA?

synthesis of double stranded RNA from an RNA template

16) Lysogeny can result in all of the following EXCEPT

immunity to reinfection by any phage

which of the following statements is false

The prophage makes the host cell immune to infection by other phages.

a persistent infection is one in which

the disease process occurs gradually over a long period

13) Which of the following is necessary for replication of a prion?

PrPSc

12) Continuous cell lines differ from primary cell lines in that

continuous cell lines can be maintained through an indefinite number of generations

a viroid is an

infectious piece of RNA without a capsid

which of the following statements about viral spikes is false

they are only found on nonenveloped viruses

which of the following statements provides the most significant support for the idea that viruses are nonliving chemicals

they cannot reproduce themselves outside a host

37) Assume a patient has influenza. During which time on the graph in Figure 13.2 would the patient show the symptoms of the illness?

c) top of biggest bump in graph

36) Assume a patient had chickenpox (human herpesvirus 3) as a child. Which line on the graph in Figure 13.2 would show the number of viruses present in this person as a 60-year-old with shingles (human herpesvirus 3)?

E0 second bump of graph

35) Some viruses, such as human herpesvirus 1, infect a cell without causing symptoms. These are called

latent viruses

34) A lytic virus has infected a patient. Which of the following would best describe what is happening inside the patient?

the virus is causing the death of the infected cells in the patient

33) Which of the following statements about viruses is FALSE?

viruses use their own catabolic enzymes

32) DNA made from an RNA template will be incorporated into the virus capsid of

hepadnaviridae

31) Viruses that utilize reverse transcriptase belong to the virus families

hepadnaviridae, and retroviridae

30) A viral species is a group of viruses that

has the same genetic information and ecological niche

29) Which of the following places these items in the correct order for DNA-virus replication?

B) 2,3,4,1 DNA synthesis, Transcription, translation, maturation

28) Generally, in an infection caused by a DNA-containing virus, the host animal cell supplies all of the following EXCEPT

DNA polymerase

27) Bacteriophage replication differs from animal virus replication because only bacteriophage replication involves

injection of naked nucleic acid into the host cell

26) Bacteriophages derive all of the following from the host cell EXCEPT

lysozyme

42) Which of the following is most likely a product of an early gene?

DNA polymerase

44) The following steps occur during biosynthesis of a + strand RNA virus. What is the third step?

synthesis of - strand of RNA

45) What contributes to antigenic shift in influenza viruses?

a segmented genome

1) The basic mechanism of viral multiplication is similar for all viruses.

true

3) Binomial nomenclature is used to name viruses.

false

4) Glycoprotein spikes are found on the capsids of all viruses.

false

6) Dogs do not get measles because their cells lack the correct receptor sites for that virus.

true

7) Helical and icosahedral are terms used to describe the shapes of a virus envelope.

false

8) Viruses are the only known infectious agents that are obligatory intracellular parasites.

false

9) A segmented genome can result in antigenic shift.

true

5) Which of the following is NOT a product of transcription?

a new strand of DNA

4) DNA is constructed of

two strands of nucleotides running in an antiparallel configuration

3) Which of the following statements is FALSE?

DNA replication proceeds in only one direction around the bacterial chromosome

1) A gene is best defined as

a sequence of nucleotides in DNA that codes for a functional product

10) Most drugs that interfere with viral multiplication also interfere with host cell function.

true

5) Positive sense RNA strands of viruses are treated like mRNA inside the host cell.

true

2) A viroid is a completely developed infectious agent composed of nucleic acid and surrounded by a capsid.

false

46) ________ were first identified in cancer-causing viruses and can induce ________ in infected cells.

oncogenes, transformation

43) Most RNA viruses carry which of the following enzymes?

RNA-dependent RNA polymerase

41) Which one of the following steps does NOT occur during multiplication of a picornavirus?

synthesis of DNA

40) Oncogenic viruses

cause tumors to develop

39) The following steps occur during multiplication of retroviruses. Which is the fourth step?

synthesis of double stranded DNA

12) Genetic change in bacteria can be brought about by

all of the answers are correct

13) Which of the following statements regarding a bacterium that is R+ is FALSE?

it is F+

20) The damage caused by ultraviolet radiation is

cut out and replaced

19) In Figure 8.2, base 2 (and ONLY the base) is covalently bound/attached to

deoxyribose

18) In Figure 8.2, if base 4 is thymine, what is base 11' (remember the complimentary configuration of bases in DNA)?

thymine

17) In Figure 8.2, if base 4 is thymine, what is base 4'?

adenine

16) Synthesis of a repressible enzyme is stopped by the

corepressor repressor complex binding to the operator

15) According to the operon model, for the synthesis of an inducible enzyme to occur, the

substrate must bind to the repressor

14) The initial effect of ionizing radiation on a cell is that it causes

the formation of highly reactive ions

no question

as naked DNA in solution

10) An enzyme produced in response to the presence of a substrate is called a(n)

indicible enzyme

9) In Table 8.1, if culture 1 mutates to Hfr, what will be the result of conjugation between the two cultures?

1 will remain the same, recombination will occur in 2

8) In Table 8.1, what will be the result of conjugation between cultures 1 and 2 (reminder: F+ has a different meaning than Hfr)?

1 will remain the same

In Figure 8.1, which colonies are streptomycin-resistant and leucine-requiring?

4 and 8

23) Refer to Table 8.2 The anticodon for valine is

CAA

34) If you knew the sequence of nucleotides within a gene, which one of the following could you determine with the most accuracy?

the primary structure of the protein

33) The mechanism by which the presence of glucose inhibits the lacoperon is

catabolite repression

In Figure 8.4, the antibiotic chloramphenicol binds the 50S large subunit of a ribosome as shown (the light gray area is the large subunit, while the black shape is the drug). From this information you can conclude that chloramphenicol

prevents translation in prokaryotes

Based on the information in Table 8.3, prostate cancer is probably the result of which kind of mutation?

nonsense

30) The necessary ingredients for DNA synthesis can be mixed together in a test tube. The DNA polymerase is from Thermus aquaticus, and the template is from a human cell. The DNA synthesized would be most similar to

human DNA

29) Conjugation differs from reproduction because conjugation

transfers DNA horizontally to nearby cells without those cells undergoing replication

28) In Figure 8.3, if enzyme A is an inducible enzyme,

compound A would bind to the repressor for gene A

27) In Figure 8.3, if enzyme A is a repressible enzyme, compound C would

bind to the corepressor for gene a

26) In Figure 8.3, if compound C reacts with the allosteric site of enzyme A, this would exemplify

feedback inhibition