DIARRHEA-CONSTIPATION AGENTS

Loperamide

Imodium (OTC) — Antidiarrheal

Loperamide PO/Function/Common Use

PO — Activates opioid mu receptor to slow down colon transit — Diarrhea

Loperamide Adverse Drug Reactions/Special Considerations

— Drowsiness, abdominal pain, dizziness — OTC

Diphenoxylate-atropine

Lomotil — Antidiarrheal

Diphenoxylate-atropine PO/Function/Common Use

PO — Activates opioid mu receptor to slow down colon transit — Diarrhea

Diphenoxylate-atropine Adverse Drug Reactions/Special Considerations

— Drowsiness, abdominal pain, dizziness — DEA Schedule V drug

Linaclotide

Linzess — Guanylate cyclase-C agonist

Linaclotide PO/Function/Common Use

PO — Adds more fluids to stool to promote colon movement — Constipation

Linaclotide Adverse Drug Reactions/Special Considerations

— Nausea, abdominal pain, drowsiness, dizziness — Take 30 minutes before meal

Lubiprostone

Amitiza — Chloride channel activator

Lubiprostone PO/Function/Common Use

PO — Adds more fluids to stool to promote colon movement — Constipation

Lubiprostone Adverse Drug Reactions/Special Considerations

— Nausea, abdominal pain, drowsiness, dizziness — Take 30 minutes before meal (to reduce nausea)

Polyethylene glycol

MiraLAX (OTC), GlycoLax (OTC) — Laxative

Polyethylene glycol PO/Function/Common Use

PO — Adds more fluids to stool to promote colon movement — Constipation

Polyethylene glycol Adverse Drug Reactions/Special Considerations

— Nausea, abdominal pain, drowsiness, dizziness — OTC