lymphocytes in the immune response

what is described as a large lymphocyte

Null (NK.K) cells

types of lymphocytes

T, B cells and Null

% of total circulating T lymphs

80%

% of total circulating B lymphs

5-15%

% total of circulating Null cells

5-15%

surface receptor of T lymphs

T cell receptor

• TCR-1 or TCR-2

surface recept or for B lymphs

• surface immunoglobulin (IgG or IgM)

• complement receptors

surface receptors for Null cells

no TCR, no surface immunoglobulin

possible surface markers for T lymphs

• CD2

• CD3

• CD4

• CD4/CD25

• CD8

possible surface markers for B lymphs

CD19

CD20

CD21

possible surface markers for Null cells

CD16

CD56

describe CD2+

rosette with SRBCs

describe CD3+

associated with TCR

CD4+ are found specifically on

T helper cells

CD4+/CD25+ are specifically found on

T regulatory cells

CD8+ are specifically found on

T cytotoxic cells

CD4 function

release cytokines ,become memory cell

CD8+ function

become cytotoxic

CD4 OR CD8 function

intereact with B cells

CD4/CD25 function

suppress immune function

function of B cells

• evolve into plasma cells which secrete antibody

• become memory cells

function of Null cells

important in killing virus infected cells and tumor cells

primary immune protection of T cells

• response against viral infections and tumors

• delayed hypersensitivity rxns

• inhibit response to self antigens

B cell primary immune function

antibodies produced :

• neutralize toxins

• activate complement

• act as opsonins

primary immune protection of NK cells

cytotixic without MHC restriction

primary immune protection of killer cells

antibody dependent cellular cytotoxicity (ADCC)

normal T cell:B cell ratio

8:1

normal T helper : T cytotoxic ratio

2:1

in an AIDs patient ,

what is the inverse T helper cell : T cytotoxic ratio

1:2