RBC Inclusions & Shapes

What are two causes of acanthocytes?

1. Hypothyroidism

2. Vitamine E deficiency

What type of anemia are target cells (codocytes) associated with?

Iron Deficiency Anemia

What are two causes of echinocytes?

1. Uremia

2. Pyruvate kinase deficiency

What are schistocytes associated with?

RBC destruction

What are keratocytes?

Helmet cells

What are Keratocytes and blister cells the result of?

Splenic pitting of Heinz bodies

Elliptocytes can appear in what four diseases?

1. Hereditary elliptocytosis

2. Thalassemia major

3. IDA

4. Megaloblastic anemia

What can cause a dacryocyte?

Primary myelofibrosis

What are three causes of stomatocytes?

1. Hereditary stomatocytosis

2. Alcoholism and liver disease

3. Rh null phenotype

What is Basophilic stippling comprised of?

RNA

What causes basophilic stippling?

1. Lead intoxication

2. Thalassemia

3. Abnormal heme synthesis

What is a cabot ring comprised of?

Remnants of the mitotic spindle

What causes a Cabot Ring?

1. Myelodysplastic Syndroms

2. Megaloblastic anemia

What are Howell-Jolly bodies comprised of?

DNA

What are Howell-Jolly bodies associated with?

1. Splenectomy

2. Megaloblastic anemia

3. Hemolytic anemia

How do you differentiate Howell-Jolly bodies from Heinz bodies?

Heinz bodies won’t show with Wright stain

What are Pappenheimer bodies composed of?

Iron

What are Heinz bodies composed of?

Denatured hemoglobin

What are Heinz bodies associated with?

1. Hemoglobinopathies

2. G6PD deficiency

What are the granules in reticulocytes made of?

Precipitated RNA

In what condition are golf balls or raspberry inclusions seen in?

Hemoglobin H