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Treatment for Malignant Hyperthermia
IV Dantrolene
Indications for IV Access
Deliver fluids
Deliver medications
Draw blood
Monitor body systems
Why are post-op patients often hypovolemic?
NPO prior to surgery
NPO post-surgery inhibition of GI tract
Blood loss due to surgery or trauma
Third spacing in surgery
who manages fluids in the OR
anesthesiologist or CRNA
Who manages post-op fluids
surgical team
4/2/1 Rule
A method of calculating the volume for maintance fluids for post-op
4 cc / kg / hr for first 10 kg
2 cc / kg/ hr for next 10 kg
1 cc / kg / hr for evert kg above 20kg
If a patient needs more post-op fluids than maintence fluods
Fluid boluses
Who may not need post-op fluids
CHF
hemodialysis
What patients may need replacement of losses with post-op
nasogastric tube
ostomy outputs
If patients can eat and drink, how do adjust maintained fluids
continue fluids at half-rate until the patient has demonstrated that he or she can keep adequately hydrated
How often are vitals done in the PACU
every 15 to 30 minutes until the patient has recovered from anesthesia and can be transferred to their room
How often are vitals done in the post-op patient
vitals every 4 hours at minimum (
best indicator of adequate volume replacement
urine output
How much fluid is loss due to insensible fluid loss
10 cc / kg / day
What are the sources of insensible fluid loss
Sweat #1
Respiratory
What can increase insensible fluid loss
Fever,
burns,
large open wounds,
ventilated patients
Average adult input/output
30-35mL/kg/day (2.4L/day)
Minimal Obligatory Daily Water input
Ingested water: 500mL
Water content in food: 800mL
Water from oxidation: 300mL
TOTAL: 1600mL
Minimal Obligatory Daily water output:
Urine: 500mL
Skin: 500mL
Respiratory tract: 400mL
Stool: 200mL
TOTAL: 1600mL
How are IVFs done after major GI surgery
the first 24 hours, use LR
After 24 hours, switch to D5 ½ NS with 20 mEq K+
Why is D5 a part of maintence
stimulate insulin release
prevent protein breakdown (prevents protein catabolism)
At 125 cc/hr, how much glucose is given from D5
150g glucose / 525 kcal
What is the fluid loss for open abdominal
0.5 to 1.0 L/h unless there are measurable blood losses
When does blood need to be replaced during open abdomen surgery
greater than 500 cc
What IVFs are isotonic
0.9% Sodium (Normal Saline [NSS])
Ringerās solution
Lactated Ringerās solution
5% Dextrose in 0.225% saline (D5 ¼ NSS)
What IVFs are hypertonic
10% Dextrose in Water (D10W)
3% Saline
5% Dextrose in 0.45% saline (D5 ½ NSS)
5% Dextrose in 0.9% saline (D5 NSS)
What IVFs are hypotonic
0.45% Saline (1/2 NSS)
5% Dextrose in Water (D5W)
Daily Na requirements
100-250 mEq
How is Na excreted
mainly urine
Daily K requirements
50-100meq
How is K excreted
mainly urine
5% feces
Daily Cl requirements
60-150meq
why NS should not be used for maintenance fluid in patients with normal renal function
risk of hyperchloremic metabolic acidosis
Daily HCO3 requirements
1 meq/kg/day
What are the body Fluid Compartments
Intracellular compartment 60-65%
Extracellular and Intravascular 35-40%
What compartment in the body is the āfirst spaceā
Intravascular compartment
What compartment in the body is the āsecond spaceā
Intracellular
What compartment in the body is the āthird spaceā
here fluid does not usually go, but may accumulate
What are the two main barriers between intravascular and intracellular
Blood-brain barrier
Blood-bone barrier
How can fluids shift in major trauma and surgery
), inflammation and reaction can cause extensive third spacing, where fluids and electrolytes (and any drugs in system) are not bioavailable
Purpose of maintenance therapy
Replace ongoing losses of water and electrolytes under normal physiological conditions
In an afebrile, non-active, not eating patient, how much free water is used daily
< 1 L
What are the approaches to maintenance fluids
Average requirement (i.e. 35 cc/kg/day)
4/2/1 rule
Weight in kg + 40 = cc / hr
What is the norma; maintained fluid
D51/2NS + 20 mEq KCl
When should we avoid D5 in maintenance fluids
Uncontrolled DM
Hypokalemia
If a patient on maintenance fluids develops hyponatremia, what can be done
Change from ½ NS to NS
Purpose of Fluid Resuscitation
: Correct existing abnormalities in volume status or serum electrolytes
What are the parameters used to assess volume deficit
Blood pressure
Jugular venous pressure
Urine sodium concentration
Urine output
Pre and post-deficit body weight
What fluids are given for severe volume depletion / hypovolemic shock
Rapid infusion of 1-2L isotonic saline (NS), then reassess parameters
Use Lactated Ringers if concern for re-expansion acidosis
What fluids are give for mild-moderate hypovolemia
Estimate fluid losses:
Choose rate 50-100mL/h greater than estimated losses
Select fluid based on type of fluid that has been lost and any co-existing electrolyte disorders
How do we estimate fluid loss for fluid resusciation
Average output (30-35mL/kg/day) + estimated additional losses
How do we estimate loss of fluid for high fevers
Add 100mL / day of loss for each degree above 37 C
Treatment for Volume Overload
Fluid restriction
Diuretics
How can volume overload occur with IVFs
too vigorous resuscitation
mobilization of third-space fluids
What is the routine post-op replacement for general abdominal surgery
Total loss ā 3500 mL
Third spacing = 1000 ml
Urine = 1000 ml
NG tube = 1000 ml
Insensible = 500 ml
Loss per hour = 146 mL/hr
Add maintenance (104)
Run at 250 mL/hr
Losses in NG tubes tend to be
High in Cl
āHep lockā
an IV catheter left in without running fluid to maintain access in an emergency or for intermittent access
āKVOā
run minimal amount of fluid, only enough to keep IV from clotting off