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Alpha–2 agonists are also called what?
Thiazine derivatives
What are the three alpha–2 agonists commonly used in veterinary medicine?
Xylazine
Detomidine
Dexmedetomidine (medetomidine used less)
Fill in the blank: These drugs are called alpha–2 agonists because they act on specific alpha–2 receptors which causes a decrease in the neurotransmitter ________.
norepinephrine
Name some of the beneficial effects of alpha–2 agonist drugs (5 total)
Muscle relaxation
Reversal agents
Analgesia (good enough for minor procedures)
Potent sedation (appear almost anesthetized)
Short duration of action
Name some of the undesirable effects of alpha–2 agonists (9 total)
Vomiting
Hypotension
Bradycardia
Respiratory depression
Sudden aggressive behaviour
Abortion
Depress GI activity
Many contraindications (not good for high risk patients)
Risk to humans (absorbed through skin)
Which class of animal is very sensitive to alpha–2 agonists?
Ruminants
What is the generic name for the alpha–2 agonist Rompun®?
Xylazine
What is the generic name for the alpha–2 agonist Dexdomitor®?
Dexmedetomidine
What is the generic name for the alpha–2 agonist Dormosedan®?
Detomidine
Can xylazine and dexmedetomidine be administered SQ, IM, and/or IV?
IM or IV (carefully, drops BP)
What is the reversal agent for xylazine?
Yohimbine (Yobine®)
What is the reversal agent for dexmedetomidine?
Atipamezole (Antisedan®)
Why is detomidine prefered in horses over xylazine?
Detomidine lessens how much horses will kick
Fill in the blank: Both xylazine and detomidine are used in horses with ______ (for analgesia and sedation) but analgesia is effective enough that it may mask worsening condition
colic
What is the reversal agent for detomidine, yohimbine and/or atipamezole?
Both yohimbine and atipamezole
Dexmedetomidine (Dexdomitor®) can decrease blood pressure, respiratory rate, temperature, and heart rate. But what does it increase?
Dexmedetomidine increases urine production
True or false: The cardiovascular effects of dexmedetomidine (eg. very slow heart rate) are dose dependent, so dosing less makes this adverse effect less
False. The cardiovascular effects of dexmedetomidine (eg. very slow heart rate) are NOT dose dependent so dosing less does not make this adverse effect less – and nor does partial reversal of the drug