Immunohematology Exam II

Why are platelet antibodies less common?

There is less phenotypical variability in the population

What are the frequencies of K and k antibodies?

K is low frequency, k is high frequency

little k is also known as

cellano

Which is a high frequency antigen, Kpa or kpb?

Kpb

Which class are Kell group antigens?

IgG

What temperature do Kell antibodies react at?

37 degrees

What phase do Kell group antibodies react at?

AHG

Is the Kell group affected by enzymes?

No

Does the kell group exhibit dosage?

some do

Which K antibody has 100% incidence?

anti-km

Which blood group is sensitive to sulhydryl reagents?

Kell group

What is the most common Kell antibody?

anti-K

What type of hemolysis is associated with Kell antibodies?

Extravascular

True or false: the abscence of Kx weaken Kell expression

True

True or false: the Kx system is autosomal

False

Which red cell morphology is caused by the lack of Xk gene?

Acanthocytosis

Which antibody class is the Kx system?

IgG

What temperature do Kx antibodies react at?

37 degrees

Do Kx antibodies display dosage?

No

Is the Kx group affected by enzymes?

No

What is the mcLeod phenotype?

The abscence of Kx

RBC abnormalities, Decreased RBC survival, neurologic defects, Chronic granulomatous disease, increased creatinine kinase, and impaired phagocytosis are all associated with what abnormal phenotype

The McLeod phenotype

fya and fyb are associated with which blood group system?

The Duffy System

which duffy alleles are associated with the black population?

fy(a-b-) and fy (a-b+)

Whcih duffy alleles are associated with the white population?

fy(a+b+), fy(a+b-)

Which system’s a-b- phenotype is resisitant to malaria?

The Duffy System

Malarial Parasites

plasmodium vivax and plasmodium knowlesi

true or false: duffy antigens cannot be found on cord blood cells

False

The most common Duffy phenotype in west african populations

fy(a-b-)

How is the duffy system affected by enzymes

inhibited

Which class are duffy antigens?

IgG

What temperature dos the duffy system react at?

37 degrees

Does the duffy system display dosage?

Yes

true or false: the fy(a-b-) phenotype has anti-fyb

False

Which stage do Duffy antigens react at?

AHG

Why does the fy(a-b-) phenotype resist malaria>

fya and fyb act as receptors for malaria.

Jk antigens are associated with which blood group?

Kidd

Which class are Kidd antibodies

IgG

How do enzymes affect the Kidd system?

Enhances

Will Kidd antibodies bind complement?

Probably

Does the Kidd system display dosage?

Yes

Which phase do Kidd antibodies react at?

AHG

Resistance to urea hemolysis and suboptimal urine concentration ability are associated with which phenotype?

Jk(a-b-)

When is Jk3 present?

When Jka and Jkb are

What temperature does the Kidd system react at?

37 degrees

Which system can sometimes have undectable antibodies, causing delayed hemolytic transfusion reactions?

Kidd

What is anti-Jk3 composed of?

anti-Jka and anti-Jkb

What is the most common Kidd phenotype in white people?

Jk(a+b+)

What is the most common Kidd phenotype in black people?

Jk(a+b-)

What is the most common Lutheran phenotype?

Lu(a-b+)

Which class is anti-Lua?

IgM and IgG

What temperature does anti-Lua react at?

RT

Which blood group antibody is associated with a mixed field?

Lutheran

is anti-Lub low or high incidence?

High

Does the Lutheran group express dosage?

No

Which Lutheran antibody is associated with HDFN?

Anti-Lua

Which race is Lub- rare in?

White people

Which blood group is associated with auburger antigens?

Lutheran

Which blood group has weak expression on cord blood cells?

Lutheran

What class are anti-lub?

IgG

Which phase does anti-lub react at?

AHG

How do enzymes affect the Lutheran group?

Enhances

The second least common lutheran phenotype

Lu(a+b-)

The second most common lutheran phenotype

Lu(a+b+)

Are Lewis antigens clinically significant?

No

Which blood group system is not an integral part of the RBC membrane?

Lewis

The most common Lewis Phenotype

Le(a-b+)

The Le/le allele codes for which Lewis antigen?

Lea

The Se/se allele codes for which lewis antigen?

Leb

What class are Lewis antibodies?

IgM

How do enzymes affect the Lewis system?

Enhances

Does the Lewis system display dosage?

No

True or false, the bombay phenotype does not display Leb

True

When will Lea antigens be found in secretions?

When Le is inherited

Which genes does one need to inherit in order for Leb to be absorbed by RBCs instead of Lea?

Se, H, and Le

What is the most rare Lewis phenotype?

Le(a+b+)

True or false: Glycoproteins get absorbed into the RBC membrane

False

What are the Lewis antigens in secretion composed of?

Glycoproteins

Which Lewis antigen is a receptor for heliobacter pylori?

Leb

Do lewis antigens show up on newborns?

No

Which Lewis phenotype is a nonsecretor?

Le(a+b-)

What temperature do lewis antibodies react at?

37 degrees or RT

True or false: newborns have i antigen on their cord blood cells

True

Are I antibodies clincally significant?

No

What class are I antibodies?

IgM

True or false: I antibodies are cold reacting.

True

I antigens are compound which which other antigen?

H

In which blood group system is it common to have autoantibodies?

The I system

Mycoplasma pneumonia and cold hemagglutinin disease are associated with which antibody?

autoanti-I

Mononucleosis, Cold agglutinins, and lymphoproliferative diease are associated with which antibody?

Anti-I

Is the P1PK system clinically significant?

No

Which class are P1Pk antibodies?

IgM

How do enzymes affect the P1Pk system?

Enhances

Does the P1Pk system display dosage?

Variable

What temperature do P1Pk antibodies react at?

Cold temperatures

Whcih phase do P1Pk antibodies react at?

RT

Whcih system is associated with the globoside system?

P1PK

Which antigens does the P1 phenotype have?

P, P1, and Pk

Which antigens does the P2 phenotype have?

P and Pk

Which antigens does the P1k phenotype have?

P1 and Pk