There is less phenotypical variability in the population
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What are the frequencies of K and k antibodies?
K is low frequency, k is high frequency
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3
little k is also known as
cellano
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Which is a high frequency antigen, Kpa or kpb?
Kpb
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Which class are Kell group antigens?
IgG
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What temperature do Kell antibodies react at?
37 degrees
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What phase do Kell group antibodies react at?
AHG
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Is the Kell group affected by enzymes?
No
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Does the kell group exhibit dosage?
some do
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Which K antibody has 100% incidence?
anti-km
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Which blood group is sensitive to sulhydryl reagents?
Kell group
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What is the most common Kell antibody?
anti-K
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What type of hemolysis is associated with Kell antibodies?
Extravascular
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True or false: the abscence of Kx weaken Kell expression
True
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True or false: the Kx system is autosomal
False
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Which red cell morphology is caused by the lack of Xk gene?
Acanthocytosis
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Which antibody class is the Kx system?
IgG
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What temperature do Kx antibodies react at?
37 degrees
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Do Kx antibodies display dosage?
No
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Is the Kx group affected by enzymes?
No
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What is the mcLeod phenotype?
The abscence of Kx
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RBC abnormalities, Decreased RBC survival, neurologic defects, Chronic granulomatous disease, increased creatinine kinase, and impaired phagocytosis are all associated with what abnormal phenotype
The McLeod phenotype
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fya and fyb are associated with which blood group system?
The Duffy System
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which duffy alleles are associated with the black population?
fy(a-b-) and fy (a-b+)
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Whcih duffy alleles are associated with the white population?
fy(a+b+), fy(a+b-)
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Which system’s a-b- phenotype is resisitant to malaria?
The Duffy System
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27
Malarial Parasites
plasmodium vivax and plasmodium knowlesi
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true or false: duffy antigens cannot be found on cord blood cells
False
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The most common Duffy phenotype in west african populations
fy(a-b-)
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How is the duffy system affected by enzymes
inhibited
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Which class are duffy antigens?
IgG
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What temperature dos the duffy system react at?
37 degrees
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Does the duffy system display dosage?
Yes
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true or false: the fy(a-b-) phenotype has anti-fyb
False
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Which stage do Duffy antigens react at?
AHG
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Why does the fy(a-b-) phenotype resist malaria>
fya and fyb act as receptors for malaria.
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Jk antigens are associated with which blood group?
Kidd
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Which class are Kidd antibodies
IgG
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How do enzymes affect the Kidd system?
Enhances
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Will Kidd antibodies bind complement?
Probably
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Does the Kidd system display dosage?
Yes
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Which phase do Kidd antibodies react at?
AHG
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Resistance to urea hemolysis and suboptimal urine concentration ability are associated with which phenotype?
Jk(a-b-)
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When is Jk3 present?
When Jka and Jkb are
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What temperature does the Kidd system react at?
37 degrees
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Which system can sometimes have undectable antibodies, causing delayed hemolytic transfusion reactions?
Kidd
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What is anti-Jk3 composed of?
anti-Jka and anti-Jkb
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What is the most common Kidd phenotype in white people?
Jk(a+b+)
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What is the most common Kidd phenotype in black people?
Jk(a+b-)
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50
What is the most common Lutheran phenotype?
Lu(a-b+)
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Which class is anti-Lua?
IgM and IgG
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What temperature does anti-Lua react at?
RT
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Which blood group antibody is associated with a mixed field?
Lutheran
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is anti-Lub low or high incidence?
High
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Does the Lutheran group express dosage?
No
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Which Lutheran antibody is associated with HDFN?
Anti-Lua
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Which race is Lub- rare in?
White people
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Which blood group is associated with auburger antigens?
Lutheran
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Which blood group has weak expression on cord blood cells?
Lutheran
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What class are anti-lub?
IgG
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Which phase does anti-lub react at?
AHG
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How do enzymes affect the Lutheran group?
Enhances
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The second least common lutheran phenotype
Lu(a+b-)
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The second most common lutheran phenotype
Lu(a+b+)
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Are Lewis antigens clinically significant?
No
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Which blood group system is not an integral part of the RBC membrane?
Lewis
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The most common Lewis Phenotype
Le(a-b+)
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The Le/le allele codes for which Lewis antigen?
Lea
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The Se/se allele codes for which lewis antigen?
Leb
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What class are Lewis antibodies?
IgM
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How do enzymes affect the Lewis system?
Enhances
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Does the Lewis system display dosage?
No
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True or false, the bombay phenotype does not display Leb
True
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When will Lea antigens be found in secretions?
When Le is inherited
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Which genes does one need to inherit in order for Leb to be absorbed by RBCs instead of Lea?
Se, H, and Le
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What is the most rare Lewis phenotype?
Le(a+b+)
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True or false: Glycoproteins get absorbed into the RBC membrane
False
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What are the Lewis antigens in secretion composed of?
Glycoproteins
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Which Lewis antigen is a receptor for heliobacter pylori?
Leb
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Do lewis antigens show up on newborns?
No
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Which Lewis phenotype is a nonsecretor?
Le(a+b-)
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What temperature do lewis antibodies react at?
37 degrees or RT
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True or false: newborns have i antigen on their cord blood cells
True
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Are I antibodies clincally significant?
No
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What class are I antibodies?
IgM
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True or false: I antibodies are cold reacting.
True
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I antigens are compound which which other antigen?
H
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In which blood group system is it common to have autoantibodies?
The I system
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Mycoplasma pneumonia and cold hemagglutinin disease are associated with which antibody?
autoanti-I
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Mononucleosis, Cold agglutinins, and lymphoproliferative diease are associated with which antibody?
Anti-I
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Is the P1PK system clinically significant?
No
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Which class are P1Pk antibodies?
IgM
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How do enzymes affect the P1Pk system?
Enhances
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Does the P1Pk system display dosage?
Variable
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What temperature do P1Pk antibodies react at?
Cold temperatures
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Whcih phase do P1Pk antibodies react at?
RT
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Whcih system is associated with the globoside system?
Studied by 3 people
