Rheumatology Disorders

Colchicine

Brand: Colcrys | Class: Antigout agent | Uses: Acute gout flares; Prophylaxis

Allopurinol

Brand: Zyloprim | Class: Antigout agent | Uses: Chronic gout

Hydroxychloroquine

Brand: Plaquenil | Class: DMARD (Disease-Modifying Antirheumatic Drug) | Uses: Rheumatoid arthritis and other autoimmune disorders

Adalimumab

Brand: Humira | Class: TNF-alpha biologic | Uses: Rheumatoid arthritis and other autoimmune disorders

Etanercept

Brand: Enbrel | Class: TNF-alpha biologic | Uses: Rheumatoid arthritis and other autoimmune disorders

Methotrexate

Brand: Trexall | Class: Antimetabolite / csDMARD | Uses: Rheumatoid arthritis and other autoimmune disorders

Upadacitinib

Brand: Rinvoq | Class: JAK inhibitor | Uses: Rheumatoid arthritis and other autoimmune disorders

Zoledronic acid

Brand: Reclast | Class: Bisphosphonate | Uses: Osteoporosis

Alendronate

Brand: Fosamax | Class: Bisphosphonate | Uses: Osteoporosis

Ibandronate

Brand: Boniva | Class: Bisphosphonate | Uses: Osteoporosis

Risedronate

Brand: Actonel | Class: Bisphosphonate | Uses: Osteoporosis

Teriparatide

Brand: Forteo | Class: PTH (Parathyroid Hormone) analog | Uses: Severe osteoporosis

Denosumab

Brand: Prolia | Class: RANKL inhibitor | Uses: Osteoporosis

Raloxifene

Brand: Evista | Class: SERM (Selective Estrogen Receptor Modulator) | Uses: Osteoporosis

Colcrys

Generic: Colchicine

Zyloprim

Generic: Allopurinol

Plaquenil

Generic: Hydroxychloroquine

Humira

Generic: Adalimumab

Enbrel

Generic: Etanercept

Trexall

Generic: Methotrexate

Rinvoq

Generic: Upadacitinib

Reclast

Generic: Zoledronic acid

Fosamax

Generic: Alendronate

Boniva

Generic: Ibandronate

Actonel

Generic: Risedronate

Forteo

Generic: Teriparatide

Prolia

Generic: Denosumab

Evista

Generic: Raloxifene

Antigout Agents - Common Side Effects

GI upset; gout flare upon initiation (allopurinol)

DMARDs / Biologics - Common Side Effects

Injection-site reactions; mild upper respiratory tract infections; nausea

Bisphosphonates - Common Side Effects

GI and esophageal irritation

Raloxifene - Common Side Effects

Hot flashes

Teriparatide & Denosumab - Common Side Effects

Mild injection-site pain

Allopurinol - Serious / Black-Box Risks

Stevens-Johnson Syndrome (SJS)

Biologics - Serious / Black-Box Risks

Severe infections and malignancy

Methotrexate - Serious / Black-Box Risks

Hepatotoxicity and myelosuppression

Bisphosphonates & Denosumab - Serious / Black-Box Risks

ONJ (Osteonecrosis of the Jaw)

Statins / Fibrates + Colchicine - High-Yield Interactions

Increased risk of myopathy

Allopurinol - High-Yield Interactions

Increases warfarin and azathioprine levels

Biologics - Absolute Contraindications

Live vaccines are contraindicated

Bisphosphonates - Absolute Contraindications

Contraindicated if esophageal stricture present or if patient cannot sit upright for at least 30 minutes