Pathologists

pathologists

diagnosticians of disease

William Osler

practice of medicine vs pathology

cornelius celsus

“four cardinal signs of inflammation”

1. rubor

2. tumor

3. calor

4. dolor

four cardinal signs of inflammation

rubor

redness

tumor

swelling

calor

heat

dolor

pain

Anton van Leeuwenhoek

• microscope

• histological stain (saffron-muscle)

Marcello Malphigi

• “Father of Histology”

• study capillaries of the skin

Giovanni Morgagni

• clinicopathologic correlation (CPC)

• cause, lesions, symptoms, and outcome of disease

Percival Pott

chimney soot (carcinogenic agent)

John Hunter

Pathologic anatomy

Richard Bright

glomerulonephritis

Thomas Addison

Adrenal insufficiency

Thomas Hodgkin

liver and spleen enlargement

Carl von Rokitansky

autopsy

Christian Gram

bacterial stains

Romanowsky

stain peripheral blood film (eosin and methylene blue)

Robert Feulgen

foundation of cytochemistry and histochemistry

Rudolf Virchow

etiology of embolism

Julius Cohnheim

concept of frozen section

Ruska and Lorries

electron microscope

George Papanicolaou

“Father of Exfoliative cytology”