cardio 1 drug quiz #1

atenolol brand name

Tenormin

atenolol primary indication

hypertension

atenolol class

beta-blocker, beta-1 selective

atenolol dose

50-100 mg PO per day

atenolol boxed warning

cessation of therapy (abrupt discontinuation can worsen cardiac conditions)

atenolol MOA

inhibits beta 1 adrenoceptors in heart (thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release)

benazepril brand name

Lotensin

benazepril primary indication

hypertension

benazepril class

ACE inhibitor

benazepril dose

10-40 PO per day

benazepril boxed warning

fetal toxicity

benazepril MOA

inhibits conversion of angiotensin I to angiotensin II

carvedilol brand

Coreg or Coreg CR

carvedilol primary indication

hypertension, heart failure with reduced ejection fraction

carvedilol class

beta-blocker with alpha blocking activity

carvedilol dose

IR: 3.125 - 25 mg PO BID

ER: 20 - 80 mg PO once daily

carvedilol boxed warning

none

carvedilol MOA

inhibits beta 1 adrenoceptors in heart (thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release); also inhibits beta 2 adrenoceptors; also inhibits alpha 1 adrenoceptors in blood vessels, thus decreasing peripheral vascular resistance

clonidine brand name

Catapres

clonidine primary indication

hypertension

clonidine class

alpha 2 agonist

clonidine dose

0.2 - 0.8 mg PO per day

patch: 0.1 - 0.3 mg per 24-hour patch applied once every 7 days

clonidine boxed warning

epidural use

clonidine MOA

inhibits beta1 adrenoceptors in heart

(thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release); also inhibits beta 2 adrenoceptors; also inhibits alpha 1 adrenoceptors in blood vessels, thus decreasing peripheral vascular resistance

enalapril brand name

Vasotec

enalapril primary indication

hypertension

enalapril class

ACE inhibitor

enalapril dose

5 - 40 mg PO per day

enalapril boxed warning

fetal toxicity

enalapril MOA

inhibits conversion of angiotensin I to angiotensin II

hydralazine brand name

Apresoline

hydralazine primary indication

hypertension

hydralazine class

vasodilator

hydralazine dose

10 - 50 mg PO QID

hydralazine boxed warning

none

labetalol brand

normodyne trandate

labetalol primary indication

hypertension

labetalol class

beta-blocker with alpha-blocking activity

labetalol dose

PO: 100 - 600 mg PO BID

labetalol boxed warning

none

labetalol MOA

inhibits beta1 adrenoceptors in heart

(thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release). Also inhibits beta 2 adrenoceptors. Inhibits alpha 1 adrenoceptors in blood vessels, thus decreasing peripheral vascular resistance

lisinopril brand name

Zestril

lisinopril primary indication

hypertension

lisinopril class

ACE inhibitor

lisinopril dose

5 - 40 mg PO once daily

lisinopril boxed warning

fetal toxicity

lisinopril MOA

inhibits conversion of angiotensin I to angiotensin II

losartan brand name

Cozaar

losartan primary indication

hypertension

losartan class

ARB (angiotensin II receptor blocker)

losartan dose

25 - 50 mg PO once daily

losartan boxed warning

fetal toxicity

losartan MOA

selective antagonist of the angiotensin II type 1 receptor (AT1R)

metoprolol succinate brand name

Toprol-XL

metoprolol succinate primary indication

hypertension, heart failure with reduced ejection fraction

metoprolol succinate class

beta-blocker, beta-1 selective

metoprolol succinate dose

12.5 - 200 mg PO once daily

metoprolol succinate boxed warning

none

metoprolol succinate MOA

inhibits beta1 adrenoceptors in heart

(thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release)

metoprolol tartrate brand name

Lopressor

metoprolol tartrate brand

Lopressor

metoprolol tartrate primary indication

hypertension

metoprolol tartrate class

beta-blocker, beta-1 selective

metoprolol tartrate dose

25 - 200 mg PO BID

metoprolol tartrate boxed warning

none

metoprolol tartrate MOA

inhibits beta1 adrenoceptors in heart

(thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release)

nebivolol brand name

Bystolic

nebivolol primary indication

hypertension

nebivolol class

beta-blocker, beta-1 selective

nebivolol dose

5 - 40 mg PO once daily

nebivolol boxed warnings

none

nebivolol MOA

inhibits beta1 adrenoceptors in heart

(thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release)

propanolol brand

Inderal LA

Inderal XL

propanolol primary indication

hypertension

propanolol class

beta blocker, non-selective

propanolol dose

80 - 160 mg PO per day in 1-4 divided dose (based on IR or ER formulation)

propanolol boxed warning

none

propanolol MOA

inhibits beta1 adrenoceptors in heart

(thus preventing norepinephrine from increasing heart rate and blood pressure) and kidney (thus preventing norepinephrine from increasing renin release); allso inhibits beta 2 adrenoceptors

ramipril brand name

Altace

ramipril primary indication

hypertension

ramipril class

ACE inhibitor

ramipril dose

2.5 - 20 mg PO per day in 1-2 divided doses

ramipril boxed warning

fetal toxicity

ramipril MOA

inhibits conversion of angiotensin I to angiotensin II

valsartan brand name

Diovan

valsartan primary indication

hypertension

valsartan class

ARB (angiotensin II receptor blocker

valsartan dose

80 - 320 mg PO once daily

valsartan boxed warning

fetal toxicity

valsartan MOA

selective antagonist of the angiotensin II type 1 receptor (AT1R)