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Examples of (+)ssRNA
Polio
Hep A
SARS
(+)ssRNA can act as mRNA
True
Where does the synthesis of new RNA viruses occur?
Cytoplasm
What does (+)ssRNA lack?
Enzyme to make progeny
What must (+)ssRNA be converted into in order to make RNA progeny?
(-)ssRNA
What enzyme does (-)RNA have that is needed to make RNA progeny?
RNA dependent RNA polymerase
Can (-)ssRNA act as mRNA?
NO
(-)ssRNA undergoes ________ to make ________ to act as mRNA
transcription
(+)ssRNA
At the same time that (-)ssRNA undergoes transcription to make (+)ssRNA, it undergoes ________ to make the (-)RNA progeny (copies)
transcription
What genome carries RNA dependent RNA polymerase?
(-) RNA
What is the disadvantage of (-)RNA? It can’t make the:
Protein coat (capsid)
What must the (-)RNA make in order to produce a protein coat?
(+)RNA
mRNA goes through the process of ________ in order to make the protein coat
translation
What genome does a retrovirus have?
(+)ssRNA
2 most known retrovirus
HIV
HTLV
Receptors that must be present in order for the retrovirus to attach and enter the host cell
CD4
CCR5
What type of spike protein do retroviruses have?
GP21
Are retroviruses enveloped?
yes
Three enzymes that the retrovirus carries
Reverse Transcriptase
Protease
Integrase
What does the reverse transcriptase allow the retrovirus to produce?
DNA from RNA
Retrovirus: After the DNA is transcribed from RNA, where does it go?
Nucleus (of host cell)
With the help of the enzyme _______ the Viral DNA integrates into the host cell DNA (they become HIV positive)
integrase
Retrovirus: After the viral DNA is integrated into the host DNA, it goes through the process of _______ to make mRNA
transcription
Retrovirus: Through the process of _______, the mRNA makes the protein coat of the virus
translation
Retrovirus: The enzyme _______ helps build proteins required for building the complete virion (with all the enzymes it needs)
protease