RAPID REVISION TABLE

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Last updated 11:50 PM on 7/16/26
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9 Terms

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PRC2

H3K27 methylation (repressive)

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PRC1

H2AK119 ubiquitination (repressive)

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PR-DUB

Removes H2AK119ub1 (deubiquitinase)

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EZH2 GoF

Hyperrepression

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EZH2 LoF

Loss of repression

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H3K27M

Global loss of H3K27me3 + gain of H3K27ac

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BAP1 LoF

Widespread H2AK119ub1 accumulation

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Tazemetostat

EZH2 inhibitor for EZH2-mutant FL (FDA approve