l2 envelope dna virus (Ebstein-Barr Virus) (Cytomegalovirus) (Other Herpes Virus)

EBSTEIN-BARR VIRUS

also known as Kissing disease

Acyclovir

treatment for ebstein-barr virus

Ebstein-Barr Virus (EBV)

Primary infection – transmitted by infected saliva and initiates infection in the oropharynx

B lymphocyte

EBV types A and B are the two major strains. Major target cell is ___

"Burkitt lymphoma"

seen in African children (tumor of the jaw)

Nasopharyngeal carcinoma

a cancer of epithelial cells and common in male Chinese people

Oral hairy leukoplakia

a wart-like growth in tongue among AIDS patients Hodgkin (Reed- Sternberg cells)

• Infectious mononucleosis – "kissing disease"

• Cancer

o "Burkitt lymphoma" seen in African children (tumor of the jaw)

o Nasopharyngeal carcinoma, a cancer of epithelial cells and common in male Chinese people

o Oral hairy leukoplakia, a wart-like growth in tongue among AIDS patients Hodgkin (Reed- Sternberg cells) and

o Hodgkin (Reed-Sternberg cells) and Non- Hodgkin lymphoma

o Gastric carcinoma

clinical findings of Ebstein-Barr Virus (EBV)

CYTOMEGALOVIRUS

can manifest as cytomegalic inclusion disease

monocytes

site of latency of cytomegalovirus

Heterophil-negative (non-EBV) mononucleosis

for normal host of cytomegalovirus

• Normal hosts – Heterophil-negative (non-EBV) mononucleosis

• Immunocompromised hosts

  • Pneumonia, colitis, retinitis or hepatitis, or cause disseminated infection

  • Virus-associated leukopenia in solid organ transplant recipients

• Congenital and Perinatal Infections – cytomegalic inclusion disease of the newborns

clinical findings of cytomegalovirus

• Ganciclovir

  • CMV infections in immunosuppressed

  • CMV retinitis, esophagitis, and colitis

  • Disseminated disease

  • Congenital infections

• Cidofovir and Foscarnet – CMV retinitis and ganciclovir- resistant CMV strains

treatment for cytomegalovirus

Human Herpesvirus 6 (HHV-6)

causes exanthem subitum (roseola infantum, or "sixth disease")

sixth disease (HHV-6)

roseola infantum

Human Herpesvirus 7 (HHV-7)

causes roseola infantum in infants and young children

Human Herpesvirus 8

(kaposi's sarcoma-associated herpesvirus, KSHV)

• foscarnet,

• famciclovir,

• ganciclovir, and

• cidofovir

treatment for HHV 8

Herpes B virus

“old world’s monkeys“

Herpes B virus

acute ascending myelitis and encephalomyelitis

acyclovir

treatment for Hrpes B virus