CHM2211 Reactions

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Last updated 1:13 AM on 9/8/26
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9 Terms

1
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Mg° / Et2O

Alkyl halide to MgX.

2
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Li° / Et2O

Alkyl halide to R-Li.

3
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  1. epoxide / 2. aq. HCl


LG substituted with opened epoxide (start with R-Li or R-MgX).

4
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  1. R-MgBr, Et2O / 2. HCl, H2O


(Open ring via less hindered), add R via SN2, cap O- with H.

5
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  1. R-Li, Et2O / 2. aq. HCl


(Open ring via less substituted), add R via SN2, cap O- with H.

6
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CuI / Et2O

2 R-Li + CuI → R2CuLi (symmetrical, taken from R-Li).

7
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R2CuLi / Et2O

Transfer 1 R (if starting with alkyl halide → halide leaves, 1 side of R2 attaches, 1° = SN2-like, 3 groups = retain stereochem).

8
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KO-t-Bu / CHCl3

Double bond to 1,1-dichlorocyclopropane, check E/Z before.

9
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CH2I2 / Zn(Cu), Et2O

Double bond to cyclopropane.