Cell Cycle Control and Tumors

Flashcards covering cell cycle control, checkpoints, and tumors from lecture notes.

The cell cycle needs to be regulated to __.

Ensure proper cell division

Cyclins and Cyclin dependent kinases (Cdks) are __.

Proteins that help cells progress from one phase of the cell cycle to the next

G2 checkpoint __.

Are all chromosomes replicated? Repaired all DNA damages or errors? Is the cell ready for division phase?

G1 checkpoint is __.

The most critical in preventing tumors

Proto-oncoproteins are __.

Proteins that promote cell division

Tumor suppressor proteins are __.

Proteins that prevent cell division

P53 protein is __.

A very important tumor suppressor protein working at G1 checkpoint

P53 works with several protein complexes to __.

Check for DNA damages, repair damaged DNA, arrest the cell at G1 checkpoint until damages are repaired, trigger apoptosis if damage is beyond repair

__ spread cancerous cells to other parts of the body by metastasis.

Malignant tumors (cancerous tumors) spread cancerous cells to other parts of the body by metastasis