ABLE 5 - Med Cards 1

Acyclovir

Brand: Zovirax

Class: viral DNA polymerase inhibitor

Common Dosing by Indication:

genital herpes simplex - initial: 400mg PO TID x 7-10 days, recurrent: 800mg PO BID x 5 days, suppression: 400mg PO BID

herpes zoster (shingles) - 800mg PO 5 times/day x 7-10 days

varicella (chickenpox) - 800mg PO 5 times/day x 5-7 days

cold sores - 400mg PO TID x 5-10 days

MOA: nucleoside analog of deoxyguanosine, phosphorylated by thymidine kinase to monophosphate, then converted to active drug acyclovir triphosphate, competitive inhibition of viral DNA synthesis by inactivating DNA polymerase and incorporation into DNA causing termination

ADE (>10%): malaise

Monitoring Parameters:

efficacy - resolution of signs of infection

safety - monitor for decreased urination, bruising/bleeding, blistering rash, SOB, confusion, lethargy, seizures

Albendazole

Brand: Albenza

Class: anthelmintic

Common Dosing by Indication:

parenchymal infection - 600mg PO BID with meals x 7-14 days

cystic hydatid - 400mg PO BID with meals x 1-6 months

MOA: degeneration of microtubules of intestinal and regimental cells of helminths, impairing glucose uptake and ATP production, leading to death of helminth

ADE (>10%): headache, elevated LFT

Monitoring Parameters:

efficacy - monitor fecal specimens for parasites for 3 weeks post treatment, repeat if still present

safety - LFTs, CBC, ophthalmic exam

Amoxicillin

Brand: Amoxil, Moxatag

Class: beta-lactate antibiotic

Common Dosing by Indication:

otitis media - 500mg PO Q8H or 875mg PO Q12H x 5-10 days

lower RTIs - 1g PO TID x 5 days

strep - 500mg PO BID or 1g PO QD x 10 days

H. pylori - 1g PO BID x 14 days (with PPI and clarithromycin)

MOA: penicillin derivative that inhibits biosynthesis of bacterial walls, active against streptococcus, enterococcus, staphylococcus, and enterobacteria

ADE (>10%): diarrhea, nausea

Monitoring Parameters:

efficacy - resolution of infection

safety - severe diarrhea, dark urine, yellowing of skin, bruising/bleeding, blistering rash, SOB

Amoxicillin/clavulanate

Brand: Augmentin

Class: beta-lactam antibiotic with beta-lactamase inhibitor

Common Dosing by Indication:

otitis media - 500mg PO Q8H or 875mg PO Q12H x 5-10 days

CAP - 500mg PO TID or 875mg PO BID x 5 days

sinusitis, skin/genitourinary infections - 500mg PO Q8H or 875mg PO Q12H x 5-7 days

MOA: penicillin derivative that inhibits biosynthesis of bacterial walls, active against streptococcus, enterococcus, staphylococcus, and enterobacteria, combined with beta-lactamase inhibitor to increase efficacy of amoxicillin against resistant bacteria

ADE (>10%): diarrhea

Monitoring Parameters:

efficacy - resolution of infection

safety - severe diarrhea, dark urine, yellowing of skin, bruising/bleeding, blistering rash, SOB

Atazanavir

Brand: Reyataz

Class: antiretroviral protease inhibitor

Common Dosing by Indication:

HIV - 300mg PO QD w/ ritonavir or cobicistat

MOA: binds to protease and inhibits cleavage of Gag-Pol polyprotein into functional proteins

ADE (>10%): rash, hyperlipidemia, elevated LFTs, abdominal pain, elevated bilirubin, cough, fever

Monitoring Parameters:

efficacy - HIV viral load, CD4 count, serum drug levels

safety - LFTs, bilirubin, glucose, EKG in pts with prolonged PR or AV node blocking drugs, CBCs, lipid panel, SCr, UA

Azithromycin

Brand: Zithromax

Class: macrolide antibiotic

Common Dosing by Indication:

COPD exacerbation, sinusitis, CAP, streptococcal pharyngitis - 500mg PO QD x 3 days or 500mg PO once then 250mg PO QD x 2-5 days

STIs, cervicitis, urethritis - 1-2g PO x 1 dose

MOA: binds 50S ribosomal subunit, interfering with bacterial protein synthesis, active against haemophilus, legionella, neisseria, bordetella, mycoplasma, and trachomatis

ADE (>10%): diarrhea, nausea

Monitoring Parameters:

efficacy - resolution of infection

safety - EKG, LFTs, CBC, hearing (if extended use), chest pain, blistering rash, fatigue

Baricitinib

Brand: Olumiant

Class: JAK inhibitor

Common Dosing by Indication:

alopecia, RA - 2mg PO QD

COVID w/ oxygen requirements - 4mg PO QD x 14 days

MOA: inhibits JAK, reducing IgG, IgM, IgA, and CRP levels and immune response

ADE (>10%): increased LFTs, infection

Monitoring Parameters:

efficacy - improvement in infection, hair growth, less joint stiffness

safety - CBC, LFTs, CrCl, lipids, hepatitis, latent TB reactivation, skin exams, change in bowel function/abdominal pain

Cefdinir

Brand: Cefdinir

Class: third generation cephalosporin

Common Dosing by Indication:

otitis media, bronchitis, streptococcal pharyngitis - 300mg PO BID x 5-10 days

COPD exacerbation - 300mg PO BID or 600mg QD x 5-7 days

MOA: beta-lactam antibiotic, active against gram negative and positive bacteria, including some beta-lactamase producing strains

ADE (>10%): diarrhea

Monitoring Parameters:

efficacy - resolution of infection

safety - renal function, anaphylaxis, severe diarrhea

Cefuroxime

Brand: Ceftin, Zinacef

Class: second generation cephalosporin

Common Dosing by Indication:

COPD exacerbation, otitis media, bronchitis, streptococcal pharyngitis - 250-500mg PO BID x 5-10 days

UTI - 250mg PO BID x 5-7 days

CAP - 500mg PO BID x 5 days (as part of combo regimen)

lyme disease - 500mg PO BID x 14-21 days

MOA: second generation cephalosporin, slight activity against beta-lactamase producing strains

ADE (>10%): diarrhea

Monitoring Parameters:

efficacy - resolution of infection

safety - jaundice, blistering rash, fatigue, bruising/bleeding, SOB, LFTs, SCr, CBC

Cephalexin

Brand: Keflex, Daxbia

Class: first generation cephalosporin

Common Dosing by Indication:

osteomyelitis, otitis media - 250-1000mg PO Q6H

streptococcal pharyngitis - 500mg PO Q12H x 10 days

impetigo - 250-500mg PO QID x 7 days

cellulitis - 500mg PO QID x 5-14 days

MOA: inhibits bacterial cell wall synthesis by binding to penicillin binding proteins, active against most gram positive bacteria including beta-lactamase producing, limited activity against gram negative

ADE (>10%): nausea

Monitoring Parameters:

efficacy - resolution of infection

safety - decreased urination, blistering rash, fatigue, bruising/bleeding, SOB, SCr, LFTs, CBC

Chlorhexidine

Brand: Peridex, Paroex, Hibiclens, Periogard

Class: antibacterial cleansing agent

Common Dosing by Indication:

gingivitis - 15 mL oral rinse BID

skin/wound cleansing - apply to skin and then rinse

MOA: polybiguanide compound, antiseptic and antimicrobial with bactericidal or bacteriostatic activity (depends on concentration), cationic drug binds to negatively charged bacterial cell wall, active against gram negative, gram positive, facultative anaerobes, aerobes, and yeasts

ADE (>10%): mouth irritation, tongue irritation, toothache, discolored teeth

Monitoring Parameters:

efficacy - resolution of gingivitis, no signs of infection

safety - tooth discoloration, skin irritation

Ciprofloxacin (PO)

Brand: Cipro

Class: fluoroquinolone antibiotic

Common Dosing by Indication:

anthrax, prostatitis - 500mg PO Q12H x 60 days

bronchitis, LRTIs, bone/skin/soft tissue infections, sinusitis - 500-750mg PO Q12H x 7-14 days

UTIs - 250-500mg PO Q12H x 3-5 days

MOA: inhibits bacterial DNA gyrase, active against aerobic and gram negative bacteria

ADE (>10%): tooth discoloration, musculoskeletal S/S

Monitoring Parameters:

efficacy - resolution of infection

safety - SCr, CBC, LFTs

Ciprofloxacin (OT)

Brand: Cetraxal, Otiprio

Class: fluoroquinolone antibiotic

Common Dosing by Indication:

otitis externa - 0.25mL to affected ear BID x 7 days

MOA: inhibits bacterial DNA gyrase, active against aerobic and gram negative bacteria

ADE (>10%): application site pain/itching

Monitoring Parameters:

efficacy - resolution of infection

safety - ear pain, local hypersensitivity, secondary fungal infection

Clarithromycin

Brand: Biaxin

Class: macrolide antibiotic

Common Dosing by Indication:

COPD exacerbation - 500mg PO Q12H x 5-7 days

CAP - 500mg PO BID x 5-14 days

HIV prophylaxis (MAC) - 500mg PO BID

H. pylori GIT infection - 500mg BID x 7-14 days with other ABX/PPI

streptococcal pharyngitis - 250mg PO Q12H x 10 days

MOA: binds to 50S and 70S ribosomal subunit, inhibits bacterial RNA-dependent protein synthesis

ADE (>10%): taste disturbance

Monitoring Parameters:

efficacy - resolution of infection

safety - palpitations, blistering rash, bruising/bleeding, jaundice, fatigue, renal function, EKG, QTc (if other QTc prolonging meds), audiogram

Clindamycin (systemic)

Brand: Cleocin

Class: lincosamide antibiotic

Common Dosing by Indication:

SSTIs, infections due to anaerobes - 150-450mg PO Q6H

LRTIs - 300-600mg PO TID x 5-7 days

PID - 450mg PO Q6H x 14 days

S. aureus septic arthritis - 600mg PO TID x 3-4 weeks

osteomyelitis - 600 mg PO TID x 6 weeks

diabetic foot infection - 300-450mg PO Q6-8H x 1-2 weeks

MOA: semisynthetic derivative, active against most gram positive bacteria and anaerobes, inhibits 50S ribosomal subunit, bactericidal or bacteriostatic depending on concentration

ADE (>10%): nausea

Monitoring Parameters:

efficacy - resolution of infection

safety - palpitations, blistering rash, diarrhea, CBC, SCr, LFT

Clindamycin (topical)

Brand: Cleocin, Clindagel, Clindesse, Evoclin

Class: lincosaminde antibiotic

Common Dosing by Indication:

acne - apply thin film BID to affected areas

bacterial vaginosis - 100mg suppository or full cream applicatorful intravaginally HS x 3 days

MOA: semisynthetic derivative, active against most gram positive bacteria and anaerobes, inhibits 50S ribosomal subunit, bactericidal or bacteriostatic depending on concentration

ADE (>10%): dry skin

Monitoring Parameters:

efficacy - resolution of acne/infection

safety - blistering rash

Diphtheria

Brand: Adacel, Boostrix, Daptacel, Infarix, Tenivac

Class: inactivated vaccine

Common Dosing by Indication:

as DTaP - dose at 2, 4, 6, and 15-18 months, and 4-6 years

as Tdap - dose at 11-12 years with booster every 10 years

MOA: n/a

ADE (>10%): injection site reactions, erythema, swelling, soreness, fever, headache, fatigue

Monitoring Parameters:

efficacy - prevention of diphtheria

safety - syncope, fever, severe local reactions

Doxycycline

Brand: Vibramycin, Doxy 100

Class: tetracycline antibiotic

Common Dosing by Indication:

actinomycosis - 100mg PO Q12H

C. trachomatis, staphylococcal skin infection, CAP - 100mg PO Q12H x 5-14 days

acne - 100mg PO Q12H once, then 100mg PO QD

MOA: broad spectrum bacteriostatic antibiotic, inhibits 30S ribosomal subunit, active against gram positive, gram negative, aerobic, anaerobic, spirochetes, mycoplasmas, rickettsiae, chlamydiae, protozoa

ADE (>10%): esophageal injury, photosensitivity, skin hyperpigmentation, tooth discoloration

Monitoring Parameters:

efficacy - resolution/prevention of infection

safety - burning/pain in stomach, headache, bloody diarrhea, tooth discoloration, SCr, LFTs, CBC

Efavirenz

Brand: Sustiva

Class: reverse transcriptase inhibitor

Common Dosing by Indication:

HIV - 600mg PO QD HS

MOA: binds HIV reverse transcriptase, blocks RNA-dependent and DNA-dependent DNA polymerase activity, preventing replication

ADE (>10%): anxiety, depression, diarrhea, dizziness, insomnia, rash, hyperlipidemia

Monitoring Parameters:

efficacy - HIV viral load, CD4 count, HIV resistance testing prior to initiation

safety - LFTs, bilirubin, CBC, lipids, mood changes, symptoms of infection

Emtricitabine/tenofovir

Brand: Truvada

Class: reverse transcriptase inhibitor

Common Dosing by Indication:

HIV - 200mg/300mg PO QD

HIV prophylaxis (PrEP) - 200mg/300mg PO QD

MOA: both drugs interfere with viral RNA-dependent DNA polymerase, inhibiting viral replication

ADE (>10%): hyperpigmentation, rash, hypophosphatemia, nausea, diarrhea, abdominal pain, weakness, cough, rhinitis, dizziness, headache, insomnia, fatigue, decreased bone density

Monitoring Parameters:

efficacy - HIV resistance testing prior to initiation, HIV viral load, CD4 count, regular screening (if used as PrEP)

safety - LFTs, bilirubin, CBC, CK, glucose, renal function, phosphorus, osteoporosis, lactic acidosis, hepatomegaly, steatosis

Erythromycin

Brand: Erythrocin

Class: macrolide antibiotic

Common Dosing by Indication:

bacterial infections - 250-500mg PO BID-QID

MOA: binds to the 50S ribosomal subunit to inhibit RNA-dependent protein synthesis

ADE (>10%): diarrhea

Monitoring Parameters:

efficacy - resolution/prevention of infection

safety - jaundice, blistering rash, fatigue, bruising/bleeding, SOB, LFTs, SCr, pyloric stenosis

Entecavir

Brand: Baraclude

Class: reverse transcriptase inhibitor

Common Dosing by Indication:

chronic HBV - 0.5-1mg PO QD

MOA: phosphorylated to guanosine triphosphate to compete with natural substrate, inhibit HBV polymerase, blocks reverse transcriptase activity, reducing viral DNA synthesis

ADE (>10%): edema, elevated LFTs

Monitoring Parameters:

efficacy - prevention/treatment of infection, HBV genotype testing prior to initiation, DNA levels obtained throughout therapy

safety - HIV status, LFTs, GGT, renal function, CBC, lactic acid, jaundice, abdominal ultrasounds, alpha-fetoprotein level

Fidaxomicin

Brand: Dificid

Class: macrolide antibiotic

Common Dosing by Indication:

C. diff infection - 200mg PO BID x 10 days

MOA: acts locally in the GIT to inhibit C. diff RNA polymerase

ADE (>10%): nausea, fever

Monitoring Parameters:

efficacy - resolution of infection

safety - bowel obstruction, bloody stool

Fluconazole

Brand: Diflucan

Class: imidazole antifungal

Common Dosing by Indication:

uncomplicated candida vulvovaginitis - 150mg PO once

complicated candida vulvovaginitis - 150mg PO Q72H x 2-3 doses

systemic candidiasis - 800mg PO once, then 400mg PO QD

cryptococcal meningitis - 1200mg PO QD x 14 days, then 400-800mmg PO QD x 8 weeks, then 200mg PO QD x 6-12 months

oropharyngeal candidiasis - 100-200mg PO QD x 7-14 days

MOA: inhibits synthesis of ergosterol, damaging fungal cell wall membrane

ADE (>10%): headache

Monitoring Parameters:

efficacy - resolution of infection

safety - skin irritation/rash, bruising/bleeding, rapid HR, jaundice, potassium, LFTs, SCr

Gatifloxacin (ophthalmic)

Brand: Zymaxid

Class: fluoroquinolone antibiotic

Common Dosing by Indication:

conjunctivitis - 0.5% solution, 1 drop to affected eyes Q2H while awake for 1 day, then BID-QID while awake x 6 days

MOA: inhibits bacterial DNA gyrase and topoisomerase IV, active against aerobic gram negative bacteria

ADE (>10%): n/a

Monitoring Parameters:

efficacy - resolution of infection

safety - eye pain, itching, redness, burning

Haemophilus influenzae type B

Brand: ActHIB, Hiberix, PedvaxHIB

Class: inactivated vaccine

Common Dosing by Indication:

as ActHIB/Hiberix - dose at 2, 4, 6, and 12-15 months

as Pedvax - dose at 2, 4, and 12-15 months

MOA: n/a

ADE (>10%): injection site reactions, erythema, soreness, headache, irritability, somnolence

Monitoring Parameters:

efficacy - prevention of infection

safety - syncope, fever, anaphylaxis

Hepatitis A

Brand: Havrix, Vaqta

Class: inactivated vaccine

Common Dosing by Indication:

as Havrix - 2 doses, 6-12 months apart

as Vaqta - 2 doses, 6-18 months apart

MOA: n/a

ADE (>10%): injection site reactions, erythema, swelling, soreness, headache, irritability, somnolence

Monitoring Parameters:

efficacy - prevention of infection

safety - syncope, fever, anaphylaxis, LFTs

Hepatitis B

Brand: Engerix-B, Recombivax HB, Heplisav-B

Class: inactivated vaccine

Common Dosing by Indication:

as Engerix/Recombivax - dose at 0, 1, and 5 months

as Heplisav - dose at 0 and 1 months

MOA: n/a

ADE (>10%): injection site reactions, erythema, soreness, fatigue

Monitoring Parameters:

efficacy - prevention of infection, antibody concentration for those w/ occupational risk

safety - syncope, fever, seizure-like activity, anaphylaxis

Human papillomavirus

Brand: Gardasil 9

Class: inactivated vaccine

Common Dosing by Indication:

as Gardasil - dose at 0, 2, and 6 months

MOA: n/a

ADE (>10%): injection site reactions, erythema, swelling, soreness, arthralgia, myalgia, headache, fever

Monitoring Parameters:

efficacy - prevention of diseases caused by HPV

safety - syncope, fever, anaphylaxis

Hydroxychloroquine

Brand: Plaquenil, Sovuna

Class: aminoquinoline

Common Dosing by Indication:

lupus - 200-400mg PO QD

malaria suppression - 400mg PO Qweek on the same day

uncomplicated malaria - 800mg PO once, then 400mg at 6, 24, and 48 hours

RA - 400-600mg PO QD

MOA: unknown

ADE (>10%): n/a

Monitoring Parameters:

efficacy - decreased pain, improved range of motion, decreased joint pain, decreased butterfly rash, improved energy, resolution of infection

safety - palpitations, rash, bruising/bleeding, changes in vision, eye exams, CBC, LFTs, SCr, glucose, electrolytes, EKG

Influenza (inactivated)

Brand: Zyclara

Class: immune response modulator

Common Dosing by Indication:

actinic keratosis - apply to affected area QD HS x 14 days, followed by 14 days off, repeat

condyloma acuminatum - apply to affected area TIW until clearance

basal cell carcinoma - apply to affected area QD 5x per week x 6 weeks

MOA: agonist of TLR-7, induces cytokines

ADE (>10%): local itching, burning, pain, erythema, xeroderma

Monitoring Parameters:

efficacy - resolution of lesions

safety - rash, burning, itching

Influenza (inactivated)

Brand: Afluria, Fluad, Flublok, Fluzone, FluLaval, Fluarix, Flucelvax

Class: inactivated vaccine

Common Dosing by Indication:

1 dose annually, prior to flu season

MOA: n/a

ADE (>10%): injection site reactions, erythema, swelling, soreness, itching, fatigue, headache, nasal congestion

Monitoring Parameters:

efficacy - prevention of infection

safety - syncope, fever, anaphylaxis

Influenza (live)

Brand: a

Class: a

Common Dosing by Indication:

a

MOA: a

ADE (>10%): a

Monitoring Parameters:

efficacy - a

safety - a

Ketoconazole (topical)

Brand: Nizoral, Ketodan

Class: imidazole antifungal

Common Dosing by Indication:

skin candidiasis, tinea corporis, tinea cruris - apply QD x 2 weeks

tinea pedis - apply QD x 6 weeks

dandruff - apply shampoo to wet hair, rinse and repeat, use every 3-4 days for up to 8 weeks, then PRN

pityriasis versicolor - apply shampoo to skin, leave on for 5 min OR apply QD x 2 weeks

seborrheic dermatitis - apply to affected area BID x 4 weeks

MOA: inhibits synthesis of ergosterol, damaging the fungal cell membrane

ADE (>10%): application site reactions

Monitoring Parameters:

efficacy - resolution of skin

safety - rash, skin irritation

Levofloxacin

Brand: Levaquin

Class: fluoroquinolone antibiotic

Common Dosing by Indication:

prostatitis - 500mg PO QD x 28-42 days

sinusitis, bronchitis, CAP, pyelonephritis - 500-750mg PO QD x 5-7 days

SSTI - 750mg PO QD x 7-14 days

MOA: inhibits bacterial DNA gyrase, active against aerobic gram negative bacteria

ADE (>10%): photosensitivity

Monitoring Parameters:

efficacy - resolution of infection

safety - renal function, LFTs, CBC

Maraviroc

Brand: Selzentry

Class: CCR5 antagonist antiretroviral

Common Dosing by Indication:

HIV - 300mg PO BID

MOA: selectively and reversibly binds CCR5 coreceptors on CD4 cells, prevents interaction between viral envelope and human cell, blocking viral entry

ADE (>10%): fever, rash, URTICARIA, cough, vomiting

Monitoring Parameters:

efficacy - HIV viral load, CD4 count, HIV resistance and genotype testing

safety - LFTs, bilirubin, cardiotoxicity

Measles, mumps, and rubella

Brand: MMR II, Priorix

Class: live vaccine

Common Dosing by Indication:

1 dose

MOA: n/a

ADE (>10%): fever, drowsiness, irritability

Monitoring Parameters:

efficacy - prevention of infection

safety - syncope, fever, anaphylaxis

Meningococcal (conjugate and polysaccharide)

Brand: MenQuadfi, Mendel, Trumenba, Bexsero, Penbraya

Class: inactivated vaccine

Common Dosing by Indication:

as MenQuadfi/Menveo - strains A, C, Y, W

as Trumenba/Bexsero - strain B

MOA: n/a

ADE (>10%): injection site reactions, erythema, swelling, soreness, irritability, abnormal crying, decreased appetite, diarrhea, malaise, fatigue, headache, asthenia

Monitoring Parameters:

efficacy - prevention of infection

safety - syncope, fever, anaphylaxis

Metronidazole

Brand: Flagyl, Likmez

Class: nitroimidazole antibiotic, antiprotozoal

Common Dosing by Indication:

intracranial abscess - 7.5mg/kg PO Q6H

amebic dysentery - 500-750mg PO Q8Hx 7-10 days

bacterial vaginosis - 500mg PO BID x 7 days

trichomoniasis - 2g PO once (males) or 500mg PO BID x 7 days (females)

MOA: active against T. vaginalis, E. histolytica, G. lamblia, bactericidal against obligate anaerobes

ADE (>10%): headaches, nausea, vaginitis

Monitoring Parameters:

efficacy - resolution of infection

safety - severe diarrhea, dark urine, jaundice, bruising/bleeding, blistering rash, SOB, CBC, neurological symptoms

Minocycline

Brand: Minocin, Emrosi

Class: tetracycline antibiotic

Common Dosing by Indication:

acne - 50-100mg PO BID

bacterial infection w/ allergy to PCN - 200mg PO once, then 100mg PO Q12H

MDR A. baumannii - 200mg PO Q12H

MOA: broad spectrum bacteriostatic antibiotic, inhibits protein synthesis at 30S ribosomal subunit, activity against gram negative, gram positive, aerobic, anaerobic, spirochetes, mycoplasmas, rickettsiae, chlamydiae, and protozoa

ADE (>10%): dizziness, vertigo, tooth discoloration, headache

Monitoring Parameters:

efficacy - resolution of infection/acne

safety - headache, bloody diarrhea, tooth darkening, jaundice, LFTs, BUN, SCr, electrolytes

Moxifloxacin

Brand: Avelox

Class: fluoroquinolone antibiotic

Common Dosing by Indication:

chronic bronchitis, sinusitis, CAP - 400mg PO QD x 5-7 days

SSTI - 400mg PO QD x 7-21 days

complicated abdominal infections - 400mg PO QD x 5-14 days

MOA: inhibits topoisomerase II and IV, broad spectrum including gram negative and positive

ADE (>10%): n/a

Monitoring Parameters:

efficacy - resolution of infection

safety - WBC, renal function, EKG

Moxifloxacin (ophthalmic)

Brand: Vigamox, Moxeza

Class: fluoroquinolone antibiotic

Common Dosing by Indication:

conjunctivitis - 1 drop to affected eye BID-TID x 7 days

MOA: inhibits topoisomerase II and IV, broad spectrum of activity including gram negative and positive

ADE (>10%): n/a

Monitoring Parameters:

efficacy - resolution of infection

safety - eye pain, itching, redness, burning