* MOA: increase Na & water excretion, inhibiting Na reabsorption in the distal tubule of kidney
* Uses: mild-moderate HPN, edema associated with CHF, cirrhosis with ascites
* Warning - decrease K, renal/hepatic dysfunction, gout
* DI:
* +lithium = lithium toxicity (N: 0.6-1.2 mEqs/L)
* +digoxin = digoxin toxicity (signs: bradycardia, N/V, visual changes; 1.0 to 2.6 nmol/l)
* +corticosteroids, amphotericin, ticarcillin = hypokalemia
* +sulfonamides = cross sensitivity
* SE/AE: hypokalemia, hyponatremia, hypomagnesemia, hypotension, bicarbonate loss, hypercalcemia, hyperglycemia, hyperuricemia, N/V, constipation, rashes, dizziness, weakness, increase LDL, photosensitivity, HA, dehydration, blood dyscrasias
* Ex. Chlorothiazide (diuril), hydrochlorothiazide (hydroduril), metalazone (zaroxolyn)