Immunology Chapter 4 Antibody Structure and Generation of B-Cell Diversity

In an adaptive immune reaction, the body is cleared of extracellular pathogens and their toxins by ___________________________________ for antigen. A mature B-cell expresses membrane-bound Ig of a single antigen specificity

antibodies, the secreted form of the B-cell receptor

Green? Yellow?

Heavy Chain; Light Chain

Red? Blue?

Variable Region; Constant Region

Five Classes of human immunoglobulin

IgM (mu), IgA (alpha), IgD (delta), IgG (gamma), and IgE (epsilon)

An antigen-binding site is formed from the ____________ of a heavy-chain V domain and a light-chain V domain

hypervariable regions

_______________ is the process by which _______________ randomly assemble different gene segments-known as ___________________ genes-in order to generate unique receptors that can recognize many different types of molecules.

VDJ recombination; T cells and B cells; variable (V), diversity (D), and joining (J

The ___________ is a Y-shaped structure that consists of two _______ and two ________ subunits

V(D)J recombinase; RAG-1; RAG-2

What enzyme adds N-nucleotides during VDJ recombination?

TdT-Terminal Deoxynucleotidyl Transferase

_______________ complex cleaves the heptamer ___________ from the D and J gene segments to yeald DNA hairpins

RAG-Recombination Activating Gene; RSS-Recombination Signal Sequence 

Membrane-bound immunoglobulins are associated with two other proteins, ______ and ______.

Igα; Igβ

(________________; light blue) encoding the transmembrane region and cytoplasmic tail of the surface form of that isotype and a ____________ sequence (orange) encoding the carboxy terminus of the secreted form.

membrane-coding, MC; secretion-coding (SC)

The monomers for pentameric IgM are cross-linked by disulfide bonds to each other and to the _______.

J chain

Monomeric IgM serves as a _____________________________ on the surface of B lymphocytes. Pentameric IgM is_____________________________________________.

membrane-associated antigen-recognition receptor; secreted into serum, or transported across epithelial cells

V(D)J recombination occurs before class switch recombination.

True