Cholesterol

Hypercholesteromaemia (Hyperlipidemia)

Management

Non-Pharmacological

• Diet

• Exercise

• Lifestyle

  • weight management

  • alcohol intake

  • smoking

Pharmacological

• Statins

• Fenofibrate

• Ezetimibe

  • Colestyamine / Colestipol hydrochloride

Statins

MMechanics of Action

live needs cholesterol - produce bile

production blocked by statin - express LDL receptors

LDL binds to receptors - reducing if from blood flow

Statins

Cautions / Contraindications

Cautions

• Elderly

• High alcohol intake

• liver disease

• hypothyroidism

• genetic polymorphisms

  • myopathy / rhabdomyolsis

Contraindications

• Sensitivity to statins/ excipients

• liver disease (active)

• Pregnancy & Lactation

• Clarithromycin use

Statins

Side Effects

Asthenia (weakness)

constipation

diarrhoea

dizziness

flatulence

GI issues

headache

myalgia

nausea

sleep issues

thrombocytopenia

Statin

Drug Interactions

Amiodarone

Clarithromycin

Fluconazole

Grapefruit

Amlodipine