Oncology Drug Charts for PBS 704

Cytotoxic chemotherapy

Causes damage to any rapidly dividing cells, not only cancer cells.

Toxicities of cytotoxic chemotherapy

Alopecia, diarrhea, mucositis, myelosuppression.

Taxanes

Prevent microtubule disassembly/inhibits M phase, CELL CYCLE SPECIFIC

Docetaxel

Prevents microtubule disassembly/inhibits M phase

Paclitaxel

Prevents microtubule disassembly/inhibits M phase

Vinca Alkaloids

Prevent microtubule formation/inhibit M phase, CELL CYCLE SPECIFIC

Vinblastine

Prevents microtubule assembly/inhibits M phase

Vincristine

Prevents microtubule assembly/inhibits M phase

Vinorelbine

Prevents microtubule assembly/inhibits M phase

Alkylating agents

DNA damage/cause cell death

Cyclophosphamide

DNA damage

Ifosfamide

DNA damage

Bendamustine

DNA damage

Melphalan

DNA damage

Cisplatin

DNA damage

Oxaloplatin

DNA damage

Carboplatin

DNA damage

Busulfan

DNA damage

Antimetabolites

Inhibit DNA synthesis/prevent cell division, CELL CYCLE SPECIFIC

Methotrexate

Folate analog

5-FU (fluorouracil)

Pyrimidine analog, inhibits DNA synthesis

Capecitabine

Pyrimidine analog

Gemcitabine

Pyrimidine analog

Pemetrexed

Inhibits thymidylate synthase, dihydrofolate reductase

6-MP (6-mercaptopurine)

Purine analog

Cytarabine

Pyrimidine analog

Fludarabine

Purine analog

Antitumor antibiotics

Only bleomycin is cell cycle specific

Doxorubicin

DNA intercalation/topoisomerase inhibitor, free radical production

Bleomycin

Alkylates DNA, causes DNA damage/stops cell cycle in G2

Irinotecan

Topoisomerase inhibitor

Topotecan

Topoisomerase inhibitor

Etoposide

Topoisomerase inhibitor

Biologics

Can cause injection site reactions, hypersensitivity reactions

Trastuzumab

Her2/Neu inhibitor

Sipuleucel-T

Prostate cancer vaccine

Ipilimumab

CTLA4 inhibitor (immune checkpoint inhibitor, ICI)

Pembrolizumab

PD-1 inhibitor (immune checkpoint inhibitor, ICI)

Nivolumab

PD-1 inhibitor (immune checkpoint inhibitor, ICI)

Bevacizumab

VEGF inhibitor

Ramucirumab

VEGFR inhibitor

Cetuximab

EGFR inhibitor

Panitumumab

EGFR inhibitor

Thalidomide

IMiD, inhibit tumor microenvironment

Lenolidomide

IMiD, inhibit tumor microenvironment

Dexamethasone

IMiD, anti-inflammatory

Prednisone

IMiD, anti-inflammatory

Asparaginase

Depletes asparagine, causes cell death

Rituximab

CD20 inhibitor

Olaparib

PARP inhibitor

Lapatinib

Her2/Neu inhibitor

Vemurafenib

Braf inhibitor

Cobimetinib

MEK inhibitor

Crizotinib

ALK inhibitor

Osimertinib

EGFR inhibitor

Erlotinib

EGFR inhibitor

Gefitinib

EGFR inhibitor

Afatinib

EGFR inhibitor

Bortezomib

Proteasome inhibitor

Imatinib

Bcr-Abl inhibitor

Dasatinib

Bcr-Abl inhibitor

Venetoclax

Bcl-2 inhibitor

Tamoxifen

SERM

Fulvestrant

SERD

Letrozole

Aromatase inhibitors

Anastrozole

Aromatase inhibitors

Bicalutamide

AR antagonist

Enzalutamide

AR antagonist

Leuprolide

LHRH agonist/inhibits androgen synthesis

Degarelix

LHRH agonist/inhibits androgen synthesis

Abiraterone

CYP17 inhibitor/inhibits androgen synthesis

Ketoconazole

Inhibits androgen synthesis