ephidrine

natural non cata

pharmacokinetics

absorption : oral

metabolism : no MAO and COMT

excretion : urine (weak basic drugs)

pharmacodynamics

effect: similar to adrenaline differences →

slow - loong 0 more alpha effect

mechanism : mixed - can pass BBB and there os action

effect of repteaed adminstration : tolerance and trachyplaxis → depletion of NA

short interval dosing : diminishes the hypertensive response

action

local: hemostatic and decongestant - active mydriatic → weak in heavy pigminted iris which is racial tolerance

systemic : as adrenaline

CVS : stimulates heart - increasing systolic and distolic BP - trachyphylaxis occur

smooth muscles : as adrenaline

CNS : STIMULATES CORTEX - RETICULAR ACTIVATING SYSTEM - vital medullary centers → insomnia

facilitation the transmission in neuro-muscular junctions

uses

prophylaxis

preventing falling of BP

myasthenia gravis

nocturnal enuresis

nasal decongestant

heart block

narcolepsy

mydriatic

adverse effects

as adrenaline +

insomnia

tolerance

retention of urine in prostatic hypertrophy