endocrine disorders

Giantism

too much hGH during childhood

Giantism

Giantism

Giantism

Acromegaly—too much hGH during adulthood

acromegaly

acromegaly:

pituatary dwarfism- lacks GH in children

pituatary dwarfism

pituatary dwarfism

Simmonds Disease—too little hGH

during adulthood

Simmonds Disease—

Diabetes Insipidus—too little ADH; shows normal urine volume and urine volume of diseased individual for 24 hours

Hyperthyroidism (Grave’s disease)—too much T3/T4

Hyperthyroidism

Hyperthyroidism

Myxedema (hypothyroidism in adults)—too little T3/T4 in adult;

shows loss of hair; thick skin; dull appearance

Myxedema

Goiter (simple)—too little Iodide in diet; low T3/T4; lack of negative

feedback so TSH is elevated (results in myxedema)

Goiter (simple)

Cretinism (hypothyroidism in infants/children)—too little

T3/T4 as infant; stunted growth, mental definciency; tongue protrudes

Cretinism (hypothyroidism in infants/children)

Cretinism (hypothyroidism in infants/children)

Aldosteronism (Conn’s disease)—too much aldosterone; shows

edema

Addison’s Disease—too little aldosterone and too little cortisol; shows

gold coloration due to high ACTH (lack of neg feedback by cortisol)

Cushing’s Disease—too much cortisol; buffalo hump, pendulous

abdomen, moonface, connective tissue degeneration

Cushing’s Disease

Cushing’s Disease

Masculinization—too much male sex hormones (androgens) in

female, beard, hairy chest, lower voice, pseudopenis

Galactorrhea/Gynecomastia—too much prolactin, inappropriate milk

production in males or female without infant

6Diabetes Mellitus—too little insulin, early patient treated with insulin

(Banting and Best)

Diabetes Mellitus—too little insulin, reduced peripheral circulation and

gangrene from injury—results in amputations

Diabetes: Mellitus—too little insulin, blood vessel friability and retinal

hemorrhage—results in blindness

Hyper-Parathyroidism—too much PTH, bones become decalcified,

rubbery, misshapen (osteitis fibrosis cystica); soft tissue calcification

Hyper-Parathyroidism

Hyper-Parathyroidism

Hypo-parathyroidism—too little PTH, blood calcium drops and causes

random muscle contractions, spasms; acute condition, can cause death

Hypo-parathyroidism