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Union of an ovum and a spermatozoon, usually occurring in the ampulla of the fallopian tube.
Fertilization
Attachment of the blastocyst to the endometrium, beginning the pregnancy proper.
Implantation
Early embryonic structure that implants; consists of an inner cell mass and trophoblast.
Blastocyst
Outer layer of the blastocyst that forms the placenta and fetal membranes.
Trophoblast
Stage from ovulation to fertilization.
Ovum Period
Fertilized egg from conception until implantation.
Zygote
Developing human from implantation to the end of 8 weeks’ gestation.
Embryo
Developing human from 8 weeks until birth.
Fetus
Collective term for the embryo/fetus and its supporting structures throughout pregnancy.
Conceptus
Earliest gestational age (about 24 weeks or 500–600 g) at which a fetus can potentially survive ex utero.
Age of Viability
Specialized endometrium of pregnancy; has basalis, capsularis, and vera regions.
Decidua
Portion of decidua lying directly beneath the embryo; forms the maternal part of placenta.
Decidua Basalis
Part of decidua that covers the implanted conceptus.
Decidua Capsularis
Remaining uterine lining not in direct contact with the conceptus.
Decidua Vera
Temporary organ serving fetal respiratory, excretory, nutritive, and endocrine functions.
Placenta
First placental hormone; basis of pregnancy tests, maintains corpus luteum early in pregnancy.
Human Chorionic Gonadotropin (hCG)
“Hormone of women”; promotes uterine growth and breast development in pregnancy.
Estrogen (Placental)
“Hormone of mothers”; maintains endometrial lining and reduces uterine contractility.
Progesterone
Placental hormone that promotes maternal metabolism of fats and glucose, stimulates breast growth.
Human Placental Lactogen (HPL)
Fetal lifeline containing one vein (oxygenated) and two arteries (deoxygenated).
Umbilical Cord
Zygote cell capable of forming any cell type in the body or placenta (first 4 days).
Totipotent Stem Cell
Embryonic cell with potential to become many—but not all—cell types (about day 5–8).
Pluripotent Stem Cell
Partially specialized cell that can develop into a limited range of cells.
Multipotent Stem Cell
Growth pattern that proceeds from head toward tail.
Cephalocaudal Development
Outer germ layer giving rise to CNS, PNS, skin, hair, nails, and sense organs.
Ectoderm
Middle germ layer forming heart, circulatory system, upper urinary system, and reproductive organs.
Mesoderm
Inner germ layer forming lining of GI and respiratory tracts and lower urinary tract.
Endoderm
Critical period (to 8 weeks) when major organs form; fetus is highly susceptible to teratogens.
Organogenesis
Any agent (drug, infection, alcohol, etc.) that can disturb fetal development.
Teratogen
First functional fetal system; heartbeat audible by Doppler at 10–12 weeks.
Cardiovascular System (Fetal)
Fetal vessel that shunts oxygenated blood from umbilical vein to inferior vena cava, bypassing liver.
Ductus Venosus
Opening between right and left atria allowing blood to bypass fetal lungs.
Foramen Ovale
Connection between pulmonary artery and aorta diverting blood away from lungs.
Ductus Arteriosus
Oxygen-high-affinity hemoglobin; higher concentration (≈17 g/dL) than adult blood.
Fetal Hemoglobin
Phospholipid mixture produced by fetal lungs that lowers alveolar surface tension.
Surfactant
Major surfactant component that surges after 35 weeks gestation.
Lecithin
Early surfactant phospholipid used with lecithin to assess lung maturity (L/S ratio).
Sphingomyelin
Embryonic structure that forms brain and spinal cord; closure depends on adequate folic acid.
Neural Tube
Neural tube defect involving herniation of meninges through spinal defect.
Meningocele
Produced by fetal pancreas; does not cross placenta from mother.
Insulin (Fetal)
Complete blockage of a hollow organ (e.g., intestinal atresia).
Atresia
Narrowing of a bodily passage, such as part of GI tract.
Stenosis
Congenital defect where intestines remain in umbilical cord at birth.
Omphalocele
Abdominal wall defect with herniated intestines free in amniotic cavity.
Gastroschisis
First neonatal stool composed of fetal waste products; dark green/black and sticky.
Meconium
Fine downy hair covering fetus that helps with insulation.
Lanugo
Cheesy protective skin coating preventing maceration in utero.
Vernix Caseosa
Mother’s first perception of fetal movement, usually at 16–20 weeks.
Quickening
Thermogenic fat deposited in fetus around kidneys, sternum, and neck by 20 weeks.
Brown Fat
Undescended testes; common in preterm males, may require surgery.
Cryptorchidism
Embryo 0.75 cm; rudimentary heart bulge; limb buds present.
Age-Related Milestone: 4 Weeks
Fetus 2.5 cm, 20 g; organogenesis complete; heart beating with chambers.
Age-Related Milestone: 8 Weeks
Fetus 7–8 cm; reflexes present; sex distinguishable; tooth buds form.
Age-Related Milestone: 12 Weeks
Fetus 10-17 cm; lanugo formed; heart tones audible by stethoscope; sex visible on ultrasound.
Age-Related Milestone: 16 Weeks
Fetus 25 cm, 223 g; quickening felt; hair and vernix present; antibody production starts.
Age-Related Milestone: 20 Weeks
Fetus 28-36 cm, 550 g; surfactant production begins; eyelids open; threshold of viability.
Age-Related Milestone: 24 Weeks
Fetus ≈1.2 kg; alveoli almost mature; testes start descent; retina vessels fragile.
Age-Related Milestone: 28 Weeks
Fetus 1.6 kg; subcutaneous fat builds; Moro reflex active; iron stores accumulate.
Age-Related Milestone: 32 Weeks
Fetus 42-48 cm; more fat and glycogen; most assume vertex position.
Age-Related Milestone: 36 Weeks
Fetus 48-52 cm, ~3 kg; fetal hemoglobin conversion begins; soles well-creased.
Age-Related Milestone: 40 Weeks
Measurement of fundal height in centimeters to estimate gestational age.
McDonald Rule
Maternal record of fetal kicks to assess well-being.
Daily Fetal Movement Count
External monitoring of fetal heart rate accelerations with movement to assess oxygenation; non-invasive.
Non-Stress Test (NST)
Use of sound to elicit fetal heart accelerations during NST.
Vibroacoustic Stimulation
Imaging technique using sound waves to visualize fetus and placenta.
Ultrasonography
Combination of NST and ultrasound evaluating fetal breathing, movement, tone, amniotic fluid, and heart rate.
Biophysical Profile (BPP)
Advanced imaging used to assess detailed fetal anatomy when ultrasound limited.
Magnetic Resonance Imaging (MRI)
Blood tests measuring specific proteins/hormones to assess risk of fetal anomalies.
Maternal Serum Screening
First-trimester invasive test obtaining placental tissue for genetic analysis.
Chorionic Villus Sampling (CVS)
Needle aspiration of amniotic fluid for genetic, enzyme, or lung maturity studies.
Amniocentesis
Guided needle sampling of fetal cord blood for diagnosis or therapy.
Percutaneous Umbilical Blood Sampling (PUBS)
Endoscopic visualization of fetus and amniotic cavity, can allow therapeutic procedures.
Fetoscopy