PTCB STUDY GUIDE – CHAPTER 19

Therapeutic Agents for the Musculoskeletal System

Which drug is an analgesic and antipyretic but not an anti-inflammatory agent?

A. Aspirin

B. Ibuprofen

C. Acetaminophen

D. Naproxen

C. Acetaminophen

The maximum daily dose of acetaminophen for most adults is:

A. 2,000 mg

B. 3,000 mg

C. 4,000 mg

D. 6,000 mg

C. 4,000 mg

Acetaminophen overdose is strongly associated with:

A. Kidney failure

B. Liver damage

C. GI bleeding

D. Neuropathy

B. Liver damage

Aspirin should never be given to children with viral illness because of the risk of:

A. Stevens–Johnson syndrome

B. Reye syndrome

C. Tachycardia

D. Hypertension

B. Reye syndrome

Which statement about aspirin is TRUE?

A. It has no effect on platelets.

B. It irreversibly inhibits COX enzymes and platelet aggregation.

C. It is not used for pain.

D. It is safer than APAP in liver disease.

B. It irreversibly inhibits COX enzymes and platelet aggregation.

A correct counseling point for ibuprofen is:

A. Take on an empty stomach only.

B. Avoid milk or food.

C. Take with food or milk to avoid GI upset.

D. Do not take with water.

C. Take with food or milk to avoid GI upset.

A major risk of NSAID use is:

A. Bradycardia

B. GI ulcer and bleeding

C. Hypoglycemia

D. Muscle cramps

B. GI ulcer and bleeding

Celecoxib (Celebrex) is a:

A. Salicylate

B. Nonselective NSAID

C. COX-2 selective inhibitor

D. Corticosteroid

C. COX-2 selective inhibitor

Celecoxib carries an increased risk of:

A. Severe hypokalemia

B. Cardiovascular thrombotic events

C. Kidney stones

D. Arrhythmia

B. Cardiovascular thrombotic events

Hydrocodone/acetaminophen (Norco) is a:

A. Non-opioid analgesic

B. COX-2 inhibitor

C. Schedule II opioid

D. Beta blocker

C. Schedule II opioid

A major boxed warning for opioid analgesics is:

A. Hemolytic anemia

B. Respiratory depression and addiction

C. Rash

D. Glaucoma

B. Respiratory depression and addiction

The most common chronic side effect of opioids is:

A. Diarrhea

B. Constipation

C. Tinnitus

D. Polyuria

B. Constipation

Naloxone is used to:

A. Induce sleep

B. Reverse opioid overdose

C. Treat constipation

D. Reduce fever

B. Reverse opioid overdose

Which medication treats opioid-induced constipation (OIC)?

A. Calcium carbonate

B. Methylnaltrexone

C. Aspirin

D. Senna only

B. Methylnaltrexone

Alendronate (Fosamax) belongs to which drug class?

A. SERM

B. Bisphosphonate

C. Corticosteroid

D. Monoclonal antibody

B. Bisphosphonate

Correct administration for oral bisphosphonates (alendronate, risedronate):

A. Take with food

B. Take with calcium

C. Take on empty stomach and remain upright 30–60 minutes

D. Take before bed

C. Take on empty stomach and remain upright 30–60 minutes

Raloxifene (Evista) is a:

A. Bisphosphonate

B. Parathyroid hormone analog

C. SERM

D. Calcitonin

C. SERM

Prolia (denosumab) is dosed:

A. Daily

B. Weekly

C. Every 6 months

D. Once yearly

C. Every 6 months

Which drug prevents gout by lowering uric acid levels?

A. Ibuprofen

B. Colchicine

C. Allopurinol

D. Prednisone

C. Allopurinol

Which lifestyle change helps reduce gout attacks?

A. Eating more red meat

B. Increasing alcohol intake

C. Weight loss and low-purine diet

D. Taking NSAIDs daily

C. Weight loss and low-purine diet

Colchicine is primarily used for:

A. Osteoporosis

B. Acute gout flares

C. Chronic pain

D. Muscle spasms

B. Acute gout flares

Which skeletal muscle relaxant is a Schedule IV drug?

A. Baclofen

B. Cyclobenzaprine

C. Carisoprodol (Soma)

D. Methocarbamol

C. Carisoprodol (Soma)

Cyclobenzaprine (Flexeril) commonly causes:

A. Insomnia

B. Drowsiness

C. Tachycardia

D. Hypotension

B. Drowsiness

Tizanidine (Zanaflex) is used for:

A. Gout

B. Spasticity (MS, spinal cord injury)

C. Chronic constipation

D. Osteoporosis

B. Spasticity (MS, spinal cord injury)

Succinylcholine is a:

A. Nondepolarizing NM blocker

B. Depolarizing NM blocker

C. Muscle relaxant

D. Opioid

B. Depolarizing NM blocker

Neuromuscular blockers such as rocuronium are used to:

A. Treat pain

B. Induce paralysis during surgery

C. Reduce inflammation

D. Improve bone density

B. Induce paralysis during surgery

Osteoporosis is defined as:

A. Bone infection

B. Loss of bone density and increased fragility

C. Excess bone growth

D. Joint inflammation

B. Loss of bone density and increased fragility

Hydrocodone/APAP prescriptions require which auxiliary label?

A. Take with grapefruit

B. May cause drowsiness—avoid alcohol

C. May discolor urine

D. Take before bed only

B. May cause drowsiness—avoid alcohol

Chronic NSAID users may need which med to prevent ulcers?

A. Antihistamine

B. Proton pump inhibitor (PPI)

C. Statin

D. Diuretic

B. Proton pump inhibitor (PPI)

Combining opioids with benzodiazepines or alcohol may cause:

A. Mild fatigue only

B. Improved pain control

C. Severe respiratory depression

D. Tachycardia

C. Severe respiratory depression

Tylenol

acetaminophen

Bayer Aspirin

aspirin

Motrin IB

ibuprofen

Aleve

naproxen

Celebrex

celecoxib

Norco / Vicodin / Lortab

hydrocodone/acetaminophen

Roxicodone

oxycodone

Duragesic

fentanyl

Fosamax

alendronate

Evista

raloxifene

Prolia

denosumab

Colcrys

colchicine

Zyloprim

allopurinol

Soma

carisoprodol

Flexeril

cyclobenzaprine