Quiz 4

What is the brand name of Fenofibrate?

Tricor

What is the generic name of Tricor?

Fenofibrate

What are the indications of Fenofibrate?

Hypertriglyceridemia

What is the drug class of Fenofibrate?

Antihyperlipidemic

What is the MOA of Fenofibrate?

Activates peroxisome proliferator-activated receptor-alpha (PPAR-α), leading to increased lipolysis and elimination of triglyceride-rich particles.

What is the BBW of Fenofibrate?

none

What are the ADR of Fenofibrate?

Hyperhomocysteinemia

What is the brand name of Ezetimibe?

Zetia

What is the generic name of Zetia?

Ezetimibe

What are the indications of Ezetimibe?

Hypercholesterolemia

What is the drug class of Ezetimibe?

Antihyperlipidemic, Cholesterol Absorption Inhibitor

What is the MOA of Ezetimibe?

Inhibits the absorption of cholesterol at the brush border of the small intestine.

What is the BBW of Ezetimibe?

none

What are the ADR of Ezetimibe?

Myopathy, increased liver enzymes

What is the brand name of Atorvastatin?

Lipitor

What is the generic name of Lipitor?

Atorvastatin

What are the indications of Atorvastatin?

Primary and secondary prevention of ASCVD, secondary prevention of CV events in patients with/at high risk for CAD

What is the drug class of Atorvastatin?

HMG-CoA Reductase Inhibitor

What is the MOA of Atorvastatin?

Inhibits HMG-CoA reductase, reducing cholesterol synthesis and increasing LDL uptake from the blood.

What is the BBW of Atorvastatin?

none

What are the ADR of Atorvastatin?

Myopathy, diarrhea, nasopharyngitis

What is the brand name of Lovastatin?

Altoprev

What is the generic name of Altoprev?

Lovastatin

What are the indications of Lovastatin?

Coronary arteriosclerosis, hypercholesterolemia

What is the drug class of Lovastatin?

HMG-CoA Reductase Inhibitor

What is the MOA of Lovastatin?

Competitively inhibit conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis

What is the BBW of Lovastatin?

none

What are the ADR of Lovastatin?

Increased creatinine phosphokinase, rhabomylosis

What is the brand name of Pravastatin?

Pravachol

What is the generic name of Pravachol?

Pravastatin

What are the indications of Pravastatin?

Hyperlipidemia, primary and secondary prevention of atherosclerotic cardiovascular disease

What is the drug class of Pravastatin?

HMG-CoA Reductase Inhibitor

What is the MOA of Pravastatin?

Inhibits HMG-CoA reductase, reducing cholesterol synthesis and increasing LDL uptake from the blood.

What is the BBW of Pravastatin?

none

What are the ADR of Pravastatin?

Musculoskeletal pain, upper respiratory infection

What is the brand name of Rosuvastatin?

Crestor

What is the generic name of Crestor?

Rosuvastatin

What are the indications of Rosuvastatin?

Hyperlipidemia, primary and secondary prevention of atherosclerotic cardiovascular disease

What is the drug class of Rosuvastatin?

HMG-CoA Reductase Inhibitor

What is the MOA of Rosuvastatin?

Inhibits HMG-CoA reductase, reducing cholesterol synthesis and increasing LDL uptake from the blood.

What is the BBW of Rosuvastatin?

none

What are the ADR of Rosuvastatin?

Arthalgia

What is the brand name of Simvastatin?

Zocor

What is the generic name of Zocor?

Simvastatin

What are the indications of Simvastatin?

Hyperlipidemia, primary and secondary prevention of atherosclerotic cardiovascular disease

What is the drug class of Simvastatin?

HMG-CoA Reductase Inhibitor

What is the MOA of Simvastatin?

Inhibits HMG-CoA reductase, reducing cholesterol synthesis and increasing LDL uptake from the blood.

What is the BBW of Simvastatin?

none

What are the ADR of Simvastatin?

Myopathy

What is the brand name of Gemfibrozil?

Lopid

What is the generic name of Lopid?

Gemfibrozil

What are the indications of Gemfibrozil?

Hyperlipidemia, coronary arteriosclerosis

What is the drug class of Gemfibrozil?

Antihyperlipidemic, Fibric Acid

What is the MOA of Gemfibrozil?

Activate PPAR-α, which increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). Activation of PPAR-α also induces an increase in the synthesis of apoproteins A-I and A-II and HDL-cholesterol

What is the BBW of Gemfibrozil?

none

What are the ADR of Gemfibrozil?

Indigestion

What is the brand name of Ranolazine?

Ranexa

What is the generic name of Ranexa?

Ranolazine

What are the indications of Ranolazine?

Chronic angina

What is the drug class of Ranolazine?

Antianginal agent

What is the MOA of Ranolazine?

Inhibits the late phase of the inward sodium channel during cardiac repolarization reducing intracellular sodium concentrations, thereby reducing calcium influx via Na+-Ca2+ exchange that in turn reduces ventricular tension and myocardial oxygen consumption

What is the BBW of Ranolazine?

none

What are the ADR of Ranolazine?

Angioedema

What is the brand name of Amiodarone?

Pacerone

What is the generic name of Pacerone?

Amiodarone

What are the indications of Amiodarone?

Secondary prophylaxis of ventricular arrhythmias

What is the drug class of Amiodarone?

Class III Antiarrhythmic

What is the MOA of Amiodarone?

Inhibits potassium channels responsible for repolarizatin of the cardiac cell membrane; Prolongs the action potential and refractory period of cardiac cells.

What is the BBW of Amiodarone?

Hepatotoxicity, proarrhythmic effects, pulmonary toxicity

What are the ADR of Amiodarone?

Nausea, Hypotension, Phospholipidemia