Oncohistone Mutations STUDY TABLE

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Last updated 11:43 PM on 7/16/26
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6 Terms

1
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Mutation

H3K27M

2
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Gene

H3F3A (H3.3) or HIST3H1B (H3.1)

3
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Tumour Type

DIPG, diffuse midline gliomas

4
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Mechanism

Dominant-negative; binds and sequesters EZH2 SET domain

5
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Effect on H3K27me3

GLOBAL LOSS

6
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Effect on H3K27ac

Increased (paradoxical)