fundamentals of immunology

which of the following is not involved in in the acquired (adaptive) immune response?

a. phagocytosis

b. production of antibody or complement

c. induction of immunologic memory

d. accelerated immune response upon subsequent exposure to antigen

answer: a. phagocytosis

which cells are involved in the production of antibodies?

B lymphocytes

which of the following cells is involved in antigen recognition following phagocytosis?

a. B lymphocytes

b. T lymphocytes

c. macrophages

d. granulocytes

answer: b. T lymphocytes

what is the role of the macrophage during an antibody response?

process antigen and present it

which immunoglobulin is produced during the secondary immune response?

IgG

which MHC class encodes complement components?

class II

which immunoglobulin is most efficient at binding complement?

IgM

which portion of the immunoglobulin molecules contains complement binding sites?

heavy chain constant region

which complement pathway is activated by the formation of antigen-antibody complexes?

classical

what is the “recognition unit” in the classical complement pathway?

C1q

what is known as the “membrane attack complex” in the classical complement pathway?

C5b, C6, C7, C8, C9

which immunoglobulin class is capable of crossing the placenta and causing hemolytic disease of the newborn?

IgG

what is the name of the effect of an excess amount of antigen present in a test system?

postzone

what is the name of the effect of an excess amount of antibody present in a test system?

prozone

which one of the following properties of antibodies is not dependent on the structure of the heavy chain constant region?

a. ability to cross the placenta

b. isotype (class)

c. ability to fix complement

d. affinity for antigen

answer: b. isotype (class)

what are molecules that promote the uptake of bacteria for phagocytosis?

opsonins

what term describes the unique confirmation of the antigen that allows recognition by a corresponding antibody?

epitope

which term refers to the net negative charge surrounding RBCs?

zeta potential

which immunoglobulin is produced during the primary immune response?

IgM