Biomedical Science - Unit 1 DNA

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30 Terms

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James Watson and Francis Crick

Discovered that DNA was double helix

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Nucleotide

Building block of DNA

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Nucleotide Bases

Fundamental building blocks of DNA and RNA. They include adenine, guanine, cytosine, and thymine. A pairs with G and C pairs with T, and hydrogen bonds form in between them.

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Sugar Phosphate Backbones

Structural framework of DNA and RNA molecules. Forms sides of DNA doble helix

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Purine-purine

Not enough space in double helix

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Pyrimidine-pyrimidine

Too much space in double helix

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Purine-pyrimdine

Just right space in double helix

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Antiparallel

In a double stranded DNA, backbones must run in this direction

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X-Ray Crystallography

Determines position of atom in molecule

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Schematic Diagrams of DNA Structure

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Space-filling Model of DNA Double Helix

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Non-covalent Interactions

Interactions between any 2 molecules or between different groups of the same molecule that don’t involve covalent sharing of electrons. Allows molecules to attract to each other. Examples: hydrogen bonds (permanent dipole), ionic, and hydrophobic effect

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Induced Dipole

Non-polar bonds; bunch of electrons orbiting around. Creates a weak dipole (ripple effect). Temporary shift of electrons in a molecule or atom that creates a temporary dipole, only lasts a fraction of a second because they even out. Occurs in O2, N2, CH4. Examples: interactions between noble gases (e.g., He–He) or non-polar hydrocarbons.

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Permanent Dipole

Polar bonds; one positive, one negative pole. Unequal sharing of electrons in a covalent bond due to differences in electronegativity. Occurs in HCl, H₂O, NH₃. One atom pulls electrons more strongly than the other, making one side partially negative (δ⁻) and the other partially positive (δ⁺). Examples: Water molecules attract each other through dipole-dipole interactions.

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Ionic Bonds

Permanent dipole can induce a dipole in another molecule. Complete transfer of electrons from a metal to a non-metal, forming oppositely charged ions. Occurs in NaCl, MgO, CaF₂. Strongest type of bond. Example: Sodium chloride (Na⁺Cl⁻), held together by strong electrostatic attraction.

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How Mutations Occur

When sequence of the DNA basis is changed

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Polymorphic Traits

Trait that appears commonly in two or more different forms

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George Mendel

Worked on how genes are passed down through one generation to the next through his pea experiment. (Genetic determinant for wrinkled genes = recessive, for round seeds = dominant). Found 3:1 dominant to recessive

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Parental Cross (P)

First cross

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Fillial (Fl)

Offspring

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Genes

Segments of four types of nucleotides in a segment of DNA

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Traits

Controlled by genes

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Two

How many alleles does each individual carry for each gene

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Genotype

Combination of alleles found in an individual

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Principle of Independent Assortment

Alleles of different genes are transmitted independently of each other

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Pedigrees

Used to examine inheritance of normal traits (or disease traits) in families

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Segregation

Separation of two alleles (50 50 chance you’ll get either of them)

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DNA

Molecule that stores instructions for building proteins

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Transcription

The process by which a gene’s DNA sequence is copied into messenger RNA (mRNA).

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Translation

The process by which the mRNA sequence is used to build a protein (a chain of amino acids) in the ribosmoe