Drugs for Angina Pectoris
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16 Terms
what is the MOA of nitroglycerin?
acts directly on VSM to promote vascular dilation, acts primarily on VEINS
therapeutic uses of nitroglycerin?
stable/variant angina
adverse effects of nitroglycerin?
headache
essential HTN
reflex tachycardia
what drug intereferes with nitroglycerin
erectile dysfunction meds
what is the MOA of Ranolazine?
lowers accumulation of Na and Ca in myocardial cells
Therapeutic uses of Ranolazine?
stable angina
Adverse effects of Ranolazine?
QT interval prolongation
CYP3A4 interferes with what drugs metabolism?
Ranolazine
what is an example of beta blockers?
Propranolol and metoprolol
MOA of beta blockers?
blocks B1 receptors in heart
Therapeutic uses of beta blockers?
stable angina
Adverse effects of beta blockers
bradycardia
lowers AV node conduction
lowers myocardial contractility
What is an example of ca-channel blockers?
Verapamil and diltiazem
MOA of ca-channel blockers
arteriole vasodilation
decreases afterload
V+D causes decreased HR
What is ca channel blockers used for?
stable/variant angina
adverse effects of Ca channel blockers
reflex tachycardia, HF, AV node block