Test 1 MOA | Quizlet

tubocurarine / atracuronium

competitive antagonists of Nm (N2) receptors.

suxamethonium

paralyse Nm (N2) receptors.

Guanifenesin

Agonist GABAr

Dantrolene

Block sarcoplasmic reticulum release of Ca2+.

Alpha agonists name

non selective - xylometazoline

a1 - phenylephrine

a2 - xylazine

alpha antagonists names

non selective - phentolamine

a1 - prazosin

a2 - yohimhine / atipamezole

Beta agonists names

non selective - isoproterenol

b1 - dobutamine

b2 - clenbuterol

beta antagonist name

non-selective propanolol

bethanechol

Parasympathomimetic:

agonist of M receptors.

Neostigmine

indirectly acting parasympathomimetic:

block hydrolysis of Ach by AchE at synapse increasing N + M receptor responses.

Atropine sulfate / scopolamine / glycopyrrolate

parasympatholytic:

competitive non selective antagonist of Ach at M receptors.

Azaperone / acepromazine

anti-psychotics.

Block D > a1 > 5-HT2 > M1 receptors.

Diazepam / midazolam

anxiolytic

activate BZD receptor on GABAa, causing hyper polarisation of neurons.

Hydroxyzine

block H1 > M1.

Pentobarbital

Agonist Of GABAa

lidocaine / procaine

Inhibit AP generation and propagation by blocking Na flux through voltage gated Na channels.

Isoflurane / sevolfurane / nitrous oxide

Inhalant aneasthesia:

Disrupt ion transfer, therefore disrupt nervous conduction of signal.

amnesia (not NO)

Propofol

general anaesthetic:

Agonist GABAa

Thiopental

general anaesthetic:

Agonist GABAa

Ketamine

General anaesthetic:

Non competitive antagonist of NMDA receptor.

morphine

analgesic

(fentanyl, etorphine)

agonist of mi-receptor > kappa receptor and delta receptor.

Butorphanol

Analgesic:

partial mi receptor agonist + full kappa receptor agonist

Naloxone

reversal agent for opioid analgesics:

antagonist of mi receptor > kappa + delta receptors.

Imipramine

antidepressant

block reuptake of NE>5-HT

block MOAa and MOAb

block M receptors

Fluoxetine

antidepressant

blocks reuptake of 5-HT.

Caffeine

Psychostimulant.

inhibits phosphodiesterase, increases cAMP release,

release epinephrine,

blocks purinergic receptors.

NSAIDS - meloxicam, flunixin, etodolac, ketoprofen, acetylsalicyclic acid, metamizol.

nhibit prostaglandin synthesis by blocking COX.