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List the 7 main 2D echo features of restrictive cardiomyopathy.
Biatrial enlargement
Preserved wall thickness, although it may be mildly thickened to <13mm
Preserved systolic function
Small to normal LV cavity size
Diffuse speckled or granular appearance of the myocardium
Possible pericardial or pleural effusion
Thickened valves
What myocardial appearance may be seen with amyloidosis?
A ground-glass appearance.
Simple reminder:
RCM usually has large atria, a small or normal LV, preserved EF, and abnormal stiff-looking myocardium.
List the 5 measurement categories that should be evaluated during an RCM echo.
LV dimensions
Diastology
LA volume
Right heart pressures
Quantitative assessment of mitral regurgitation
List the 3 main abnormal variables used to assess LV diastolic function and estimate LAP.
Reduced eā² velocity
Increased E/eā² ratio
Increased TR velocity or PASP
What values indicate reduced eā² velocity?
Septal eā² ā¤6 cm/s
Lateral eā² ā¤7 cm/s
Average eā² ā¤6.5 cm/s
What values indicate an increased E/eā² ratio?
Septal E/eā² ā„15
Lateral E/eā² ā„13
Average E/eā² ā„14
What TR velocity or PASP indicates an abnormal value?
TR velocity ā„2.8 m/s
PASP ā„35 mmHg
If all 3 variables are normal, what is the estimated LAP?
Normal LAP.
If all 3 variables are abnormal, what is the estimated LAP?
Increased LAP.
How are Grade II and Grade III diastolic dysfunction separated once LAP is elevated?
E/A <2 = Grade II
E/A ā„2 = Grade III
List the 5 diastolic findings associated with restrictive cardiomyopathy.
whats the grade?
E/A Ratio
DT, IVRT, eā, E/eā
Elevated filling pressures with Grade II or greater diastolic dysfunction
E/A ratio >2, indicating Grade 3 dysfunction ( E wave increased A reduced resistrictive pattern)
Short deceleration time, <150 ms
Short IVRT, <60 ms
eā² <7 cm/s (both septal and lateral lateral walls e ā reduced)
E/eā² >14 (elavted filling pressures*)
(short steep e wave DT, LV stiffeness causes raise in filling pressureleads to early stopping of filling, filling pressure increase - grade 2 or higher)
Simple reminder:
Restrictive filling = large E wave, small A wave, short DT, short IVRT, low eā², and high E/eā².
List the 3 pulmonary vein Doppler findings associated with RCM.
Progression to a dominant _____pattern
S/D ratio = what
Has a prominent what velocity & talk about the duration
Progression to a dominant diastolic pattern
S/D ratio <0.5 S < D
Prominent atrial reversal velocity with an atrial A duration > mitral
inflow A duration
Simple reminder:
High LA pressure causes the pulmonary vein D wave to dominate and increases atrial reversal.
Differential Diagnosis for Pulmonary veins
Normal at young age ( < 40 years old)
High LA pressure at older age
AFIB
Moderate to severe MR
RCM
(High LVEDP, short pr interval, intra - atrial conduction delay)
List the 2 main right-heart findings in RCM.
RA enlargement
TR is usually present because of biatrial enlargement
List the 4 measurements used to quantify MR severity.
EROA
Regurgitant volume
Regurgitant fraction
Vena contracta
List the 4 values that indicate mild MR.
EROA <0.20 cm²
Regurgitant volume <30 mL
Regurgitant fraction <30%
Vena contracta <0.3 cm
List the 4 values that indicate moderate MR.
EROA 0.20ā0.29 cm²
Regurgitant volume 30ā44 mL
Regurgitant fraction 30ā39%
Vena contracta 0.3ā0.7 cm
List the 4 values that indicate moderate-to-severe MR.
EROA 0.30ā0.39 cm²
Regurgitant volume 45ā59 mL
Regurgitant fraction 40ā49%
Vena contracta 0.3ā0.7 cm
List the 4 values that indicate severe MR.
EROA ā„0.40 cm²
Regurgitant volume ā„60 mL
Regurgitant fraction ā„50%
Vena contracta ā„0.7 cm
what is the Continuity Equation for MR
MV stroke volume = MV CSA Ć MV VTI
LVOT stroke volume = LVOT CSA Ć LVOT VTI
Regurgitant volume = MV stroke volume ā LVOT stroke volume
Regurgitant fraction = MR regurgitant volume Ć· MV stroke volume
EROA = MR regurgitant volume Ć· MR VTI
what is the PISA for MR
PISA flow rate = 2Ļr² Ć aliasing velocity
PISA EROA = PISA flow rate Ć· peak MR velocity
Regurgitant volume = EROA Ć MR VTI
List the 4 M-mode features of RCM.
Biatrial enlargement
Normal or small LV cavity size
Normal or increased LV wall thickness
Pleural or pericardial effusion
PRACTICE
A calculated MR regurgitant volume is 45 mL. How is the MR graded?
Moderate-to-severe MR, because a regurgitant volume of 45ā59 mL is moderate-to-severe.
PRACTICE
Interpret the following diastolic measurements: E/A 1.1, E/eⲠ34.8, LAVI 52 mL/m², and TR peak velocity 2.7 m/s.
E/eā² of 34.8 is severely elevated and indicates increased filling pressure.
LAVI of 52 mL/m² is severely enlarged.
TR velocity of 2.7 m/s is below the 2.8 m/s abnormal cutoff.
The overall findings support elevated LAP and significant diastolic dysfunction, even though the E/A ratio is not above 2.
PRACTICE
Interpret an MR PISA regurgitant volume of 70 mL and EROA of 0.5 cm².
Both values indicate severe mitral regurgitation because:
Regurgitant volume is ā„60 mL
EROA is ā„0.40 cm²
PRACTICE
Interpret the following measurements: E/A 2.07, E/eⲠ31, LAVI 86 mL/m², and TR peak velocity 3.3 m/s.
E/A 2.07 indicates Grade III restrictive diastolic dysfunction.
E/eā² 31 indicates markedly elevated filling pressure.
LAVI 86 mL/m² indicates severe LA enlargement.
TR velocity 3.3 m/s indicates elevated pulmonary pressure.
These findings support advanced restrictive physiology with markedly elevated LAP and pulmonary hypertension.
PRACTICE
What does a TR peak velocity of 3.3 m/s indicate?
It is above the 2.8 m/s abnormal cutoff and supports elevated right-heart or pulmonary artery pressure.
List the 10 major echo findings that support restrictive cardiomyopathy.
Biatrial enlargement
Small to normal LV cavity
Normal or mildly increased LV wall thickness
Preserved systolic function early
Speckled or granular myocardium
Grade II or III diastolic dysfunction
E/A ratio >2 in Grade III
Short DT and IVRT
Low eā² and elevated E/eā²
Pulmonary hypertension, TR, and possible pleural or pericardial effusion