chapter 3: adverse reactions
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18 Terms
what is an adverse reaction?
an unwanted drug reaction
what are the types of adverse reactions?
side effects
toxic reaction
allergic reaction
which adverse reactions are predictable?
side effect and toxic reaction
which adverse reactions are dose relatied?
side effect and toxic reaction
what do side effects act on?
non-target organs
what do toxic reactions act on?
target organs
what are the types of selected drug interactions?
drug drug
drug food
drug disease
what is the acronym for hypersensitivity types?
ACID
what is type i hypersensitivity?
anaphylaxis
what is the mediator for type i hypersensitivity?
antibody IgE
what is type ii hypersensitivity?
cytotoxic - kills other cells
what is the mediator for type ii hypersensitivity?
antibody IgG and IgM
what is type iii hypersensitivity?
immune complex
what is the mediator for type iii hypersensitivity?
antibody IgG
what is type iv hypersensitivity?
delayed
what is the mediator for type iv hypersensitivity?
t lymphocytes and macrophages
what does idiosyncrasy mean?
not a drug side effect/allergic reaction
how are idiosyncrasy reactions usually determined by?
genetics