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Myasthenia Gravis
Postsynaptic location.
Autoantibodies destroy Acetylcholine receptors.
Curare
Acetylcholine is still released from the nerve.
Acetylcholine receptors are affected because this blocks them (none are available)
Flaccid Paralysis
postsynaptic
Botulinum Toxin (Botox)
prevents Acetylcholine release.
Acetylcholine receptors are unaffected
flaccid paralysis
presynaptic
myasthenia gravis
reduced ACh receptors
receptors are destoryed so less in number
fatigable weakness