PORG (FINALS): AMINES

Amines

compounds in which one or more of hydrogens of ammonia have been replace by alkyl group

Ammonia

3 hydrogen

Primary amine

1 carbon

Secondary amine

2 carbon

Tertiary amine

3 carbon

Fishy odor

smaller amines are characterized by their __ odor

fermented shark (greenlands shark)

example of ammonia rich smell. a traditional dish in iceland.

*poisonous when fresh due to high content of urea and trimethylamine oxide

pyrrolidone

pyrrole

piperidine

pyridine

aniline

pyrimidine

purine

Cytosine (D&R)

Uracil (R)

Thymine (D)

D=DNA

R=RNA

PYR CUT meaning

3 pyrimidine bases

Guanine (D&R)

Adenine (D&R)

PUR GA meaning

Purine

Amine

Amide

Imine

nitrile

Nitrogen compounds

primary and secondary amine

__ and __ amines have higher molecular formula than alkane with similar molecular weight

alcohol

amines has lower boiling point than __ with similar molecular weight

Catecholamine

COMMON PHARMACEUTICAL DRUG:

refer generally to all organic compounds contain catechol nucleus (ortho-dihydroxybenzene) and ethylamine group

epinephrine,

dopamine

norepinephrine

catecholamine example (30

adrenergic drug

medication that stimulate certain nerves in your body.

They do this by mimicking the action of chemical messengers or by stimulating their release

catechol

ortho dihydroxybenzene with ethylamine

epinephrine

COMMON PHARMACEUTICAL DRUG:

hormone and neurotransmitter used to treat allergic reactions to restore cardiac rhythm

*common is epipen

adrenaline

epinephrine AKA

Norepinephrine

COMMON PHARMACEUTICAL DRUG:

naturally occurring chemical in body that acts as both stress hormone and neurotransmitter

Norepinephrine

• Increases alertness, arousal and attention

• increases sleep by exiting subset of neurons in VLPO (ventrolateral preoptic)

• play role in person’s mood and ability to concentrate

• low in this may cause ADHD

Dopamine

COMMON PHARMACEUTICAL DRUG:

• neuromodulatory molecule plays important role in cell

• important body function like movement, memory and pleasurable reward and motivation.

• provide intense feeling of reward

• happy hormone

Non-catecholamines

COMMON PHARMACEUTICAL DRUG:

compounds lacking catechol hydroxyl group.

phenylephrine

ephedrine

amphetamine

example of Non-catecholamines (3)

Phenylephrine

COMMON PHARMACEUTICAL DRUG:

decongestant that is used to treat stuffy nose and sinus congestion caused by the common cold, hay fever, or other allergies.

Neozep® Forte

contains Phenylephrine HCL, Chlorphenamine Maleate and Paracetamol.

Phenylephrine HCl

Chlorphenamine Maleate

_____ a nasal decongestant clears obstructed air passages and nasal sinuses due to congestion making breathing easier. It also reduces postnasal drip.

____ an anti-allergy, relieves symptoms such as runny nose, sneezing, and itchy, watery eyes.

Paracetamol is an effective fever reducer and pain reliever.

Neozep® Non-Drowsy

contains Phenylephrine HCl and Paracetamol.

Ephedrine

COMMON PHARMACEUTICAL DRUG:

prescription medicine used to treat the symptoms of low blood pressure during anesthesia (Hypotension).

Arteries

A= ALPHA = __

Beats (heart-b1), Breaths (lungs-b2)

1= constrict

2= dilate

B-BETA =___

asthma

constriction

B2 agonist = __

A1 agonist = ___ of blood vessels & shrinkage of swollen nasal mucous membrane = reducing nasal congestion

Amphetamine

COMMON PHARMACEUTICAL DRUGS:

(contracted from alpha- methylphenethylamine)

is a central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.

dopamine, norepinephrine, and serotonin

Amphetamine is (CNS) system stimulant that functions by increasing the amounts of __,__, and __ (to a lesser extent)

Diazepam

COMMON PHARMACEUTICAL DRUGS:

medicine for anxiety, muscle spasms and seizures

Lorazepam

COMMON PHARMACEUTICAL DRUGS:

is a short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.

Benzodiazepine nucleus

COMMON PHARMACEUTICAL DRUGS:

work by enhancing a very important neurotransmitter called GABA (gamma-aminobutyric acid) at the GABA A receptor.

sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties for which the drugs are prescribed.

Gabapentin

- approved to prevent and control partial seizure (anticonvulsant)

- mirrors the effects of GABA calming excited neurons.

Verapamil

COMMON PHARMACEUTICAL DRUGS:

treat hypertension, to treat and prevent chest pain (angina)

type of medicine called a calcium channel blocker.

Febuxostat

used to lower hyperuricemia (high uric acid in the blood) in patients with gout who have been treated with allopurinol that did not work well or cannot be treated with allopurinol.

This medicine is a xanthine oxidase inhibitor. It works by causing less uric acid to be produced by the body.