Blood Coagulation

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12 Terms

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Blood thinners

Antiplatelets, Anticoagulants, Thrombolytics

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Blood thinners adverse fx

BLEEDING

→is pt having a surgery/procedure?

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ANTIPLATELETS

ARTERIAL THROMBUS

→Ischemic stroke, MI, PAD, ACS

→ASSESS: upcoming procedures, decreased Hgb, Hct Plt, BP, bruising

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Two types of ANTIPLATELETS

P2Y12 ADP receptor antagonist

Aspirin

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P2Y12 ADP receptor antagonist

Clopidogrel

Prasugrel

→irreversible

Ticagrelor→reversible if stopped

maintenance of vessel graphs/stents

arterial thrombus

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Aspirin baby

cardiovascular prevention

fever, pain, acute MI

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ANTICOAGULANTS

VENOUS THROMBUS

DVT, Pulmonary Embolism, Stroke

Heparin, Low Molecular Weight Heparin, Warfarin, DOACs

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Heparin

FAST-ACTING (wears off fast)

Hospital-use only

treatment IV, SUBQ prevention

→Heparin-induced thrombocytopenia (lowers platelet)

→MONITOR ANTI Xa & PTT

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Low Molecular Weight Heparin

Enoxaparin

prevention of ischemic conditions, MI, angina

pre-filled syringe (home med)

→HIT

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Warfarin

(1-2) normal range INR

Mr bleed (2-3) →for patient

SLOW-ONSET

closely monitor INR

→Vitamin K as an antidote

AFIB

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DOACs

Apixaban

Rivaroxaban

risk reduction for TIA & MI

→more easier to manage

AFIB

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Thrombolytics = “Clot Busters”

Alteplase

Tenecteplase

for already formed clots

EMERGENCY SITUATIONS

extremely high risk requires close monitoring