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5-6 Liters
Volume of blood in the average male?
4-5 Liters
Volume of blood in the average female?
Plasma
Liquid part of the blood that carries nutrients and wastes, 92% water in composition, 55% of blood volume
Erythrocytes, Leukocytes, Platelets
What are the three main formed elements in blood?
Hematocrit
Ratio of volume of red blood cells to rest of the blood
Exercise
Name a way red blood cell numbers can increase
Interstitial fluid
Name the fluid that is present in extracellular space in capillary beds
Arteriole
Name for a small artery before a capillary bed
Venule
Name for a small vein after a capillary bed
Albumin
Protein that regulates osmotic pressure, has a high molecular weight, and affects blood flow in capillaries
Globulin
Protein for antibodies, has a high bonding affinity to target molecules
Fibrinogen
Protein that forms fibrin
Carbohydrates, Proteins, Lipoprotiens
List nutrient types found in blood
Oxygen and Carbon Dioxide
List the two main blood gasses
Ammonia, Ammonia is toxic even in small amounts
Nitrogenous compounds such as urea, uric acid, creatine, and creatinine all form ____________ if left out. Why is this negative?
Electrolytes
Nutrient compounds that conduct electricity
Cations
Particles that have a positive charge such as Na+
Anions
Particles that have a negative charge, such as Cl-
Hydrogen cations H+ (protons)
Which particles make a solution acidic?
Hydroxyl anions OH-
Which particles make a solution basic?
hemocytoblast
stem cells that give rise to all the formed elements of the blood
Erythrocytes
Name for a red blood cell, 4-6 million/mm^3 of blood
1. CO
2. O2
3. CO2
4. N2 (does not bind)
Rank the following compounds in order of highest to lowest bonding affinity. O2, CO2, CO, N2
A biconcave structures gives flexibility while also increasing surface area for gas exchange
Why are erythrocytes biconcave?
More gases can be bound to hemoglobin structure inside cell than just saturating blood solution with gasses
Why are blood gases bound to hemoglobin in RBCs?
Approx. 120 days, it is filtered and re-purposed by the Spleen
How long is a RBC's life span? What happens after death?
Gas carrying capability is reduced, can stick in blood vessels forming clots
What are 2 problem caused by sickle shaped red blood cells?
Liver
Heme groups found in RBC are formed by enzymes in which organ?
Biliverdin
Bile pigment that is involved in heme group catabolism in a bruise, gives a green color to skin
Bilirubin
Bile pigment that is involved in heme group catabolism in a bruise, gives yellow color to skin present when bruise is almost healed
Granulocytes, dyes that stain them
Leukocyte group with Neutrophils, Eosinophils, and Basophil?
Where are names derived from?
Agranulocytes
Leukocyte group with Monocytes and Lymphocytes?
Neutrophil
Multinucleated, phagocytic (eats other cells or debris) leukocyte
Eosinophil
Bilobed nucleus, phagocytic (eats other cells or debris) leukocyte, involved in chemotaxis (releases chemicals that cause movement)
Basophil
Produce heparin (inhibits clotting), produces histamine (causes inflammation and swelling) leukocyte
Monocytes
Horseshoe shaped nucleus, phagocytic (eats other cells or debris) leukocyte
Lymphocyte
Leukocyte with big smooth nucleus, gives specific immunity to the body
T, B, K
List 3 types of leukocytes
Megakaryocytes
irregular shaped cell with frayed edges that look like amoeboid projects that break off to form platelets
Platelets
Elements that form plug in hemostasis
1. Vasoconstriction
2. Formation of platelet plug
3. Fibrin formed from fibrinogen
4. Damage repaired with cell divison
5. Clot is dissolved
6. Vasodilation
List 6 steps of Hemostasis
Spasm that constricts blood flow to slow bleeding
Define vasoconstriction
Pressure slows blood loss
How does a platelet plug help to stop bleeding?
Lysosomes
Which enzymes dissolve the clot formed in hemostasis?
Relaxation of blood vessel to resume normal blood movement
Define vasodilation
Agglutinogen
Antigen surface present in blood cells
Agglutinin
Antibody present in blood plasma
O
Blood type that contains no Agglutinogen types
A
Agglutnin Anti B binds with Agglutinogen ___?
B
Agglutnin Anti A binds with Agglutinogen ___?
AB
Which blood type contains no Agglutinin types?
Rh factor
Surface protein from rhesus monkeys that indicates the "positive" or "negative" in blood type names
When the donor is Rh positive but Host is Rh negative, forms Anti-Rh factor upon exposure
When would a hazardous situation regarding blood transfusions occur with regard to Rh factor?
Vena cava
Main vein that returns blood to the heart from the body
Aorta
Main artery that brings blood from the heart to the body
Chordae Tendinae
Connection between heart valves and muscles that close them
Pappilary muscles
Muscles that are responsible for closing heart valves
Tricuspid valve
Valve between right atrium and right ventricle
Biscuspid valve
Valve between left atrium and left ventricle
Pulmonary semilunar valve
Valve between right ventricle and pulmonary artery
Aortic semilunar valve
Valve between left ventricle and aorta
Atrioventricular septum
Wall between atria and ventricles
Interatrial septum
Wall between atria
Interventricular septum
Wall between ventricles
Atria then Ventricles
List the order of heart chamber contraction
120:80 mm Hg
Average human blood pressure
Systolic, contraction
First number in blood pressure ratio corresponds to which type of pressure?
Diastolic, relaxation
Second number in blood pressure ratio corresponds to which type of pressure?
Small amount of blood squirts back into previous heart chamber
What is a heart murmur?
AV valves closing then semilunar valves closing
What makes the typical heart sounds heard while the heart beats?
Presence of the foramen ovale and ductus arteriosus
to bypass the pulmonary circuit
What are the 2 main differences in a fetal heart? Why are these structures present?
opening flap doesn't open as much and connective tissue seals the gap forming the Fossa Ovalis
When a baby is born, what should happen to the foramen ovale?
It collapses from pressure change to stop bypass of pulmonary circuit
When a baby is born, what should happen to the Ductus Arteriosus?
Left and right coronary arteries
What supplies the myocardium with blood?
Circumflex
Continuation around heart at level of the AV septum
Epicardium
Them membrane outside the heart
Myocardium
Middle muscular layer of the heart
Endocardium
Interior lining of the heart
Anterior and Posterior Interventricular Arteries
Supplies blood to the interventricular septum and surrounding areas of the heart
Lesser and Greater, Middle and Posterior Cardiac vein
Carries away blood used by heart
Coronary suclus
Where do blood vessels that supply the heart with blood lie around the heart?
Coelomic cavity
Open space surrounded by serous membrane in early development before being divided into body cavities
Thoracic and Peritoneal (abdominal)
Two cavities that are formed when coelomic cavity's sides are compressed
Diaphragm
What divides thoracic and abdominal cavities?
Parietal pleura
Outer serous membrane of thoracic cavity near lungs
Visceral pleura
Serous membrane directly on top of lungs
Parietal pericardium
Outer serous membrane of thoracic cavity near heart
Visceral pericardium
Serous membrane surrounding heart
Parietal peritonum
Outer serous membrane of abdominal cavity
Visceral peritoneum
Serous membrane around digestive tract
Organs develop from the outside and push in to have membrane on surface
How do organs end up covered in the serous membrane in the body cavities?
Mesentary
Serous membrane layers with nothing in between in digestive tract that is anchored to bodily wall
Storage of mesentaric fat, and stability
What is mesentary used for?
Greater omentum
Part of digestive system near stomach used for fat storage
Cranial nerve X, Vagus
What major nerve connects directly to the heart?
Sinoatrial node
Where does the Vagus nerve connect to the heart?
Atrioventricular node
Present at AV junction, marks where nerve changes from tight cord to bundles
AV Bundle of His
Branches of nerve found in AV septum
Purkinje fibers
Nerve fibers present in ventricular wall
Intercalcalated Disk
Plate between adjacent cardiac muscle, locally coordinates contraction