General Pathology Lecture 11: Hypersensitivity Type II

What are the two antibodies related to Type II hypersensitivity?

1. IgG

2. IgM

What are the three mechanisms of Type II Hypersensitivity?

1. Opsonization

2. Cellular dysfunction

3. Inflammation

What is the process of binding cells with antibodies

Opsonization

What is changed during cellular dysfunction?

Cell function

What system is activated for inflammation?

Complement

What are the three reactions of type II hypersensitivity related to opsonization?

1. Transfusion reactions

2. Hemolytic anemia

3. Rhesus disease

What are the two conditions of the first pregnancy that leads to rhesus disease?

1. Mother has Rh- RBCs

2. Exposed to Rh+ fetus RBCs

What happens to subsequent pregnancies in rhesus disease?

Maternal IgG antibody lyses fetal RBCs

What are mothers treated with after the first pregnancy to manage rhesus disease?

RhoGAM

Which blood type is the universal recipient?

AB

Which blood type is the universal donor?

O

What cellular dysfunction disease is caused by antibodies bind to TSH receptors on thyroid?

Graves disease

What is caused by Graves disease?

Hypersecretion in thyroid

What cellular dysfunction disease is caused by antibodies binding to receptors on skeletal muscle?

Myasthenia gravis

What does Myasthenia gravis block?

Binding/stimulation of ACh

What does Myasthenia gravis result in?

Muscle weakness