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Stratum Basale
one layer
keratinocytes (specialized epithelial cells)
melanocytes
tactile cells (nerve endings)

stratum spinosum
several layers
daughter cells into highly specialized keratinocyte
epidermal dendritic cells/intraepidermal macrophages
phagocytes
stratum granulosum
3-5 layers of keratinocytes
cytoplasm fills with keratin filaments (organelles begin to degrade)
fully keratinized cells are dead but strong and water insoluble

stratum lucidum
thin, transulcent, few layers
palms and soles
lack organelles
eleidin: transparent, intermediate product of keratin maturation

stratum corneum
few-30 layers thick depending on location
dead keratinocytes
cornified = corneocytes
sloughed off by abrasion

skin color epidermal variation
hemoglobin: pinkish hue
melanin: melanocytes
carotene: foods
skin markings epidermal variation
Nevus: mole
Hemangioma: proliferation of blood vessels (permanent: port-wine)
friction ridges: folds of epi and dermis, fingerprints (dermatoglyphics)
Dermis CT
Papillary: Loose (areolar) CT, dermal papillae and epidermal ridges, increase surface area and provide vascularity.
Reticular (80%) : Dense irregular CT, collagen fibers, blood vessels, glands, hair follicles, and nerves. connected to hypodermis
Hypodermis
Subcutaneous Layer
areolar (loose, proper) and adipose CT (loose proper)
protects, stores energy, insulation, vascularized

sebaceous glands
oily sebum into hair follicles
activates during puberty

aprocrine sweat glands
simple coiled tubular
hair follicles into pubic areas
thick, cloudy, proteins and lipids > leading to bacterial growth
merocrine sweat glands
simple coiled tubular
water clear, nervous system
thermoregulation, secretion, protection
lunula
white semilunar proximal area of nail body caused by thickened
underlying stratum basale obscuring capillaries in dermis
hair papilla
connective tissue, nerves, and blood vessels
below follicle that support the keratinocytes
hair bulb
a swelling at bottom of follicle filled with dividing keratinocytes; increase in hair matrix causes hair growth
ceruminous glands
cerumen (earwax), protects