immunosero 1

Edward Jenner

Introduced Vaccination against smallpox and cross-immunity

Ellie Metchnikoff

cellular theory of immunity through phagocytosis

Rosalyn yalow, Solomon Berso

Developed Radioimmunoassay technique

Cesar Milstein, George Kohler

devised Hybridoma technology

Gerald Edelman, Rodney Porter

Discovered the chemical structure of antibody

Susumo Tonegawa

discovery of genetic principle of Antibody diversity

Natural Immunity

Innate/nonspecific

Adaptive Immunity

Acquired/specific

Natural Immunity

Immediate Immunologic response

Natural Immunity

Immunologic memory is Absent

Natural Immunity

1st and 2nd line of defense

Adaptive Immunity

Slow immunologic response

Adaptive Immunity

Immunologic memory is present

Adaptive Immunity

3rd line of defense

First line of defense

consist of anatomical barriers that prevent infectious agents from infecting the body

First line of defense

Ex. Intact skin, mucous membranes, cilia in respiratory tract

5.6 pH

PH of the skin

Second line of defense (cellular)

• Phagocytic cells

• Antigen presenting cells

• Natural killer cells

Second line of defense (humoral)

• Complement system

• Interferons

Antigen presenting cells

Present antigen to lymphocytes

Dendritic cells

Most effective APC

Cellular component

Composed of immune cells