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What are the layers of protection for the CNS?
skull, meninges, CSF
what are the two pathways the brain uses to reach the spinal cord and brainstem?
direct, indirect pathways
the direct pathway is responsible for what type of movement?
fine motor movements
the indirect pathway is responsible for what type of movement?
gross, crude reflexive movements
basal ganglia fxn:
on/off switch for movement
if the direct pathway is always upregulated what occurs?
all motor plans will be ON, excess constant movement
Huntingtons disease would be a result of an upregulated _____ pathway
direct
if the indirect pathway is always on what occurs?
no movement!
someone with an upregulated indirect pathway might present with what disease?
parkinsons
injury to the spinal cord results in loss of ability to send the output to the peripheral system resulting in _______.
paralysis
the feet and LE are present on what portion of the motor homonculus?
medial
the arm and face are present on what side of the motor homunculus?
lateral side
a stroke of the MCA would affect what portion of the homunculus?
Lateral, ex arms, face,
a stroke of the anterior cerebral artery affects what part of the body?
lower extremities (medial homunculus)
the cortical pathway overarching is responsible for ____ movement/
fine
the corticospinal tract fxn
voluntary motor function to hand, legs (distal extremities)
corticobulbar tract function
connects cerebral cortex to brainstem motor nuclei (LMN), to control fave, head, and neck movements
if the subcortical nuclei fires unanswered, there will be an increase in _____.
tone
the red nucleus and rubrospinal tract are responsible for what?
posturing of the limbs
cortical injury and inhibition affecting the red nucleus would have what result on musculature?
produces flexion of UE and extension of LE (decorticate posturing)
what tract would be responsible for postural control and catching us when we fall?
vestibulospinal tract
a cortical lesion of the vestibular nucleus and vestibulospinal tract would have what effect on the body?
increase in tone
a cortical lesion would affect the reticular formation and reticulospinal tract how?
increase in tone
the corticospinal tract splits into what 2 portions?
lateral corticospinal tract, anterior corticospinal tract
_____% of the corticospinal tract will decussate at the medullary pyramids and ___% will stay not cross
90, 10
lateral corticospinal tract fxn:
voluntary skill movement, distal mms, hands fingers, feet.
anterior corticospinal tract fxn:
axial and proximal mms.
what part of the basal ganglia is responsible for producing dopamine?
substantia nigra
lack of dopamine leads to what disease?
parkinsons
cerebellum function
motor learning, adaption of movement, execution of movement plan
vestibular organ sense are _____ of the cortex
independent
what senses does the DCML pick up?
proprioception, vibration, 2 pt discrimination, graphesthesia
what senses to the anterior and lateral spinothalamic tracts pick up?
pain, temperature, crude touch, pressure
what information does the spinocerebellar tract pick up?
proprioceptive mm, and joint sense information from posture mm and LE
descending pathways travel in the _____ and _____ SC. ascending pathways travel in the _____ and ____ SC
lateral, anterior, posterior, medial
autonomic tracts are found in the _____ spinal cord
thoracic
what are the two motor components of the peripheral nervous system?
alpha motor neurons, gamma motor neurons
muscle spindles, GTOs; fxn:
tell us where mms are in space
joint proprioception:
tells us where joints are in space
mechanoreceptors fxn:
sensations of light touch, vibration, pain and temperature
what system makes up 80% of total cerebral blood flow?
internal carotid system
what system makes up 20% of blood flow to the brain
vertebral basilar system
what cerebral artery is most likely to infarct?
middle cerebral a. because its the first small vessel of ant. circulation
spasticity
increased tone or muscular resistance to movement
a coordination deficit usually indicates an injury where?
cerebellum
a sensory and perception deficit usually indicates injury to what?
sensory cortex or higher cortical sensations
describe an UMN lesion:
injury to anything in the cortex, descending tracts, CNS
describe an LMN lesion
peripheral nervous system injury
what symptoms would you see in someone with an UMN lesion?
slight atrophy, spastic w increased DTRs, + babinski, - fasicular twitches, normal NVC, no denervation in EMG
what are some common diagnoses that are UMN?
CVA, MS, Huntingtons disease, parkinson’s, head injury
what are some symptoms of a LMN
pronounced individual muscle atrophy, decreased tone, no DTR - babinski, + fascicular twitches, abnormal NCV, + EMG with fibrillationc
common diagnoses of LMN
bells palsy, carpal tunnel, Gillian barre, herpes zoster