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Cerebrosides
It is the simplest glycosphingolipid in the body
Ceramide (Fatty Acid + Sphingosine) and a single sugar residue (the head group)
Cerebrosides contains?
Glucose (glucosylcerebroside or GlcCer) or galactose (galactosylcerebroside or GalCer)
Cerebrosides contains either?
Galactosylcerebroside or GalCer
It is the major lipid of myelin
Glucosylcerebroside GlcCer
It is the major glycosphingolipid of extraneural tissues but also present in small amounts in the brain.
Cerebrosides, Sulfatides (Sulfogalactosylceramides), Globoside, Gangliosides
Major types of glycolipids
Glycolipid
It is a lipid that contains both fatty acid an a carbohydrate component attached to a sphingosine molecule.
Sugar / Carbohydrate
Glycolipid has _____________ instead of phosphate group.
cerebrosides
It is the simplest sphingoglycolipids
Gangliosides
It is the complex sphingoglycolipids
Nervous tissue, brain
Glycolipids are widely distributed in every tissue of the body, particularly in ________ such as ____.
outer leaflet
Glycolipids occur particularly in the ___________ of the plasma membrane.
Sulfatides
Also called as Sulfogalactosylcereamides
C3 sulfated
Sulfatides are ___________ cerebroside (specifically, a galactosylcerebroside)
cerebroside 3-sulfate
It is the other term for C3 sulfated cerebroside
Sulfatides
It is present in high amounts of myelin
Sulfatides
It is present in early stages of alzheimer’s disease
Globoside
It contains Cerebroside + 2 or more sugars
N-acetylgalactosamine
The side chain of globoside is?
C1
Where is the oligosaccharide of globoside attached?
Gangliosides
-It is a complex glycosphingolipids derived from glucosylceramide that contain in addition one or more molecules of sialic acid
-A lot of sugar attached to it
glucosylceramide, sialic acid
Ganglioside is a complex glycosphingolipids derived from __________ that contain in addition one or more molecules of _____.
Hydroxyl group
Sterol has the presence of?
Cholesterol
It is the major sterol in the body
Hydrophobic
Cholesterol is hydrophilic or hydrophobic?
Three 6-membered rings, one 5-membered ring
Cholesterol is a lipid whose structure is based on a fused ring system that involves ______________ and ___________.
plasma membrane, plasma lipoproteins
Sterols are major constituent of _________ and ________ .
Nervous tissue
Sterols are widely distributed in all cells of the body but particularly in __________.
bile acids, steroid hormones (adrenocortical and sex hormones), vit D
Sterols are precursors of _______, _________ (________ and ______) and ________.
proteins
Cholesterol, bound to ________, is transported to tissues vessels
low-density lipoproteins (LDL)
Cholesterol in ________ tends to deposit and clog arteries
stabilizer
Sterols act as a ________ by modifying membrane fluidity (phase transition temperature).
