RNA Polymerase II TFs

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9 Terms

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Pol II

Catalyzes RNA synthesis

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TBP (TATA binding protein)

Specifically recognizes the TATA box; associated with promoter

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TFIIA

Stabilizes binding of TFIIB and TBP to the promoter

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TFIIB

Binds to TBP and recruits Pol II–TFIIF complex

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TFIID

Required for initiation at promoters lacking a TATA box

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TFIIE

Recruits TFIIH; has ATPase and helicase activities

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TFIIF

Binds tightly to Pol II; binds to TFIIB and prevents binding of Pol II to nonspecific DNA sequences

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TFIIH

Unwinds DNA at promoter (helicase activity); phosphorylates Pol II CTD (carboxy-terminal domain); recruits nucleotide-excision repair protein

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ELL, pTEFb, TFIIS, and Elongin (elongation factors)

These factors suppress pausing/arrest of transcription by the Pol II complex.