IPS 1 DDS - PRACTICE SETS I - III

A product designed for administration to the body in the diagnosis or treatment of disease is called

- resins

- injection

- drug

- dosage form

dosage form

A device that holds a drug and may be in direct contact with the drug

- transdermal drug delivery

- insert

- container

- labels

container

A container that protects the contents from extraneous solids and from loss of the article under ordinary conditions of handling and shipment storage and distribution

- all

- Tightly closed container

- Hermetic container

- Well closed container

Well closed container

What type of packaging is not easily tampered

- Blister pack

- Bubble pack

- Aerosol

- Tape seal

Aerosol

According to the USP, the instruction "protect from light" in a monograph indicates storage in a

- Light resistant container

- Dark place

- Tight glass container

- Amber glass bottle

- Hermetic container

Light resistant container

Single dose parenteral container

I. is a hermetic container

II. ampule

III. permits withdrawal of successive portions of the content

a i and iii

b i and ii

c ii and iii

d i ii and iii

I and II

The USP limits the size of single dose containers to

20mL

1000mL

500mL

30mL

1000mL

According to USP Standards, a refrigerated can be used to store pharmaceutical that specify storage in a

Room temperature

Cold place

Freezer

Cool place

Cold place

Based on USP guidelines the stability of extemporaneously compounded aqueous liquids (reconstituted formulations) is

- Not later than 14 days when stored at cold temperature

- Not less than the intended duration of therapy or 30 days whichever is earlier

- Maximum beyond use date us 6 months or 25% of the remaining time between the compounding date and then the shortest expiration date of the ingredients, whichever is earlier

- Beyond use date of not later than 25% of the time remaining until the products' expiration date or 6 months whichever is earlier

Not later than 14 days when stored at cold temperature

The following are examples of single-dose parenteral containers EXCEPT;

- Pre-filled syringes

- Cartridges

- Fusion-sealed amppule

- 30 mL-capacity vials

30 mL-capacity vials

Photodegradation can be prevented by packaging drugs in a light resistant container. Which of the following containers is NOT light resistant?

- bottle covered with carbon paper

- amber colored bottle

- colorless bottle covered with aluminum foil plastic bottle

plastic bottle

The following route of administration will provide the highest concentration of drugs in the blood

- intramuscular

- intravenous

- oral

- rectal

intravenous

Type II glass container is

- soda lime glass

- highly resistant borosilicate glass

- general purpose soda lime glass

- treated soda lime glass

treated soda lime glass

It is used to mask the bitter taste of the product

- Fruits or citrus flavor

- Orange, Cinnamon and Raspberry

- cocoa

cocoa

The disadvantage of Sodium Saccharin as a sweetening agent is

- Bitter after taste

- It has a carcinogenic potential

- Contraindicated with phenylketonurics

- 130X as sweet as sucrose

Bitter after taste

Which is TRUE: FD&C yellow #5

- Can cause allergic reaction to patient allergy to penicillin

- all

- It is permitted to used externally

- Known to be Tartrazine

Known to be Tartrazine

In preparing lipsticks which type of colorant should not be used

- Any of the above

- F D and C

- D and C

- External D and C

External D and C

The following are frequently used ophthalmic preservatives except

- Phenylmercuric nitrate

- Chlorobutanol

- Benzalkonium chloride

- Propylparaben

Propylparaben (antifungal)

100% proof alcohol is

- absolute alcohol

- 95% ethyl alcohol

- 50% ethyl alcohol

- 100% ethyl alcohol

50% ethyl alcohol

An approach to stabilize preparations against hydrolytic decomposition EXCEPT

- Removal of water

- Use of buffering agent

- Use of antioxidant

- Supplying the drug in dry form for reconstitution

Use of antioxidant

Which of the following is NOT an antioxidant

- Sodium bisulfite

- Benzoic acid

- Alphatocopherol

- Ascorbic acid

- Butylhydroxyanisole

Benzoic acid (preservative)

Which of the following is an example of oxidation of an organic, active drug molecule?

- Loss of hydrogen from alcohol hydroxyl group

- Gain electron (s) by the drug molecule

- Addition of hydrogen to a carbon-carbon double bond

- Decrease in valence of the drug molecule

Loss of hydrogen from alcohol hydroxyl group

The major ingredients in most dosage forms of aqueous solution is

- Aromatic water

- water

- Acidulated water

- Alcohol

water

Dosage forms employed to combat infection

- all

- vaginal tablet

- A and B

- vaginal suppository

- oral tablet

all

Products for external use

- Any color as long as the statement "For external use only"

- Red colored label

- White colored label

- Any will do

Red colored label

Any substance combined with an active ingredients to make latter agreeable to convenient dosage is called:

- Diluent

- Disintegrator

- Excipients

- Lubricant

Excepients

The product inserts for many drug products Contain cautionary statements. Which One of the following sequences lists the Three types of cautions in the order of least Serious to most serious?

- warning, precaution, contraindication

- contraindication, precaution, warning

- warning, contraindication, precaution

- contraindication, warning, precaution

- precaution, warning, contraindication

precaution, warning, contraindication

The preparation of a specific dosage form for a patient with specific needs is called

Extemporaneous compounding

Bulk compounding

Bulk manufacturing

Product formulation

Extemporaneous compounding

These substances are used to prevent the drying out of preparations due to the agent's ability to retain moisture.

antioxidant

levigating agent

humectant

occluding agent

plasticizer

humectant

Most drugs are

Strong electrolyte

Weak electrolytes

Highly electrolyte

Non electrolyte

Weak electrolytes

The term "drug labeling" includes the following EXCEPT:

brochure

None

Inserts

Company literature

Labels

None

Artificial sweetener are added to syrup preparations to:

Prevents hyperglycemia

Acts as preservatives

Aid acidic syrup

Serves as aesthetic agents

Prevents hyperglycemia

Which of the following provides the best definition of pharmaceutics? It is the study of dosage form design, including associated manufacturing techniques

- It is the study of how drugs can be chemically synthesised

- It is the study of the effect that the body has on drugs

- It is the study of dosage form design, including associated manufacturing techniques

- It is the study of the effect that drugs have on the body

It is the study of dosage form design, including associated manufacturing techniques

Instructions involving the proper route of administration of a drug is most significant for

Suppositories

Suspensions

Tablets and capsules

Ophthalmic drops

Ointments

Suppositories

This method of degradation occurs in both water in oil soluble drugs as well as fixed volatile oil

oxidation

solvolysis

polymerization

photolysis

oxidation

Which one of the following medicines does not rely on topical drug delivery?

Insulin pen

Nasal spray

Nicotine patch

Anti-dandruff shampoo

Insulin pen

This should be included in the label of drugs associated with serious adverse reaction:

FDA Category

Contraindication

Pregnancy category

Black Box Warning

Black Box Warning

When incorporating potent substances in powder, the process used is

Levigation

Pulverization by intervention

Geometric dilution

Block and divide method

Geometric dilution

The most accurate method of extemporaneously preparing divided powders although time consuming

Weighing to individual doses

Estimation

all of these

Blocking and dividing

Weighing to individual doses

Particle terminology is essential in the formulation and manufacture of:

Aerosols

Powders

Capsules

All

All

Combinations of mixtures of drugs which liquefy due to a lowering of their melting point

Eutectic mixture

Deliquescent

Efflorescent

Hygroscopic

Eutectic mixture

Hygroscopic and deliquescent substances may be incorporated into powders by:

Addition of lubricant

Both A and B

Double wrapping

Addition of diluents

Both A and B

A waterproof paper that is commonly used to wrap hygroscopic and deliquescent materials

Bond paper

Wax paper

Vegetable Parchment

Glassine paper

Wax Paper

The process of grinding a drug in a mortar to reduce the particle size is termed:

Spatulation

Tumbling

Levigation

Trituration

Trituration

What are the main ingredients of effervescent granules:

Sodium carbonate, citric acid and tartaric acid Sodium bicarbonate, ascorbic acid and tartaric acid

Sodium carbonate, ascorbic acid and sodium tartrate

Sodium bicarbonate, citric acid, tartaric acid

Sodium bicarbonate, citric acid, tartaric acid

In preparing effervescent granulated salts, which of the following statement/s hold/s TRUE:

I. Effervescent granules can be prepared using two methods, the dry and the wet

II. The effervescent from the released CO serves to mask the bitter or salty taste of the drug

III. Using tartaric acid as the sole acid would result in a sticky mixture which is difficult

a i and ii

b ii and iii

c i and iii

d i ii and iii

I and II

The following are true about granules except:

More likely to cake or harden upon standing that powders

More easily "wetted" by a solvent than a certain powder

More stable physically and chemically than are the corresponding powders from which they were prepared

Their surface area is less than that of a powders

More likely to cake or harden upon standing that powders

Efflorescent powders when triturated or stored in low humidity releases

Dust

Carbon dioxide

Bad smell

Water

Water

A very fine powdered chemical is defined as one that will;

Completely pass through a #40 sieve and not more than 40% through a #80 sieve Completely pass through a #20 sieve and not more than 40% through a # 60 sieve Completely pass through a # 80 sieve no limit to greater fineness Completely pass through no.8 sieve and not more than 20 % through sieve no. 60. Completely pass through a #60 sieve and not more than 40% through a #100 sieve

Completely pass through a # 80 sieve no limit to greater fineness

Finely divided powders introduced into body cavity such as vagina, ears, nose, throat are

Douche powder

Triturations

Insufflations

Triturations

Insufflations

All of the following are appropriate actions when dispensing bulk medicated powders EXCEPT

- Mixing oral powders with a liquid for administration

- Inclusion of antimicrobial drugs in topical preparations

- Provision of a supplemental device to measure the dosage amount

- Inclusion of potent or low dosage active drug

Inclusion of potent or low dosage active drug

Ideal containers for dispensing dusting powders

Wide mouth bottles

Paste board boxes

Amber colored bottles

Sifter to container

Sifter top container

The term "impalpable" refers to a substance that is

greasy

tasteless

not perceptible to touch

colorless

not perceptible to touch

The spatulation process is well suited for mixing of which of the following powder.......

Effervescent

Hygroscopic

Volatile

Eutectic

Eutectic

A convenient method for mixing redox substance is.....

Tumbling

Spatulation

trituration

Sifing

Spatulation

Powders used for external use are ...

Divided powder

Bulk powder

Dusting powder

Effervescent powders

Dusting Powder

Bulk powders are .....

Both are correct

Potent

None

Non-potent

Non-potent

Insufflations are introduced into which of these body cavities

All of these

Throat

Ears

Nose

All of these

oral powders are ......

Finely divided

Bulk powders

Effervescent powders

Douche powders

Finely divided

contain mixtures of citric acid, tartaric acid, or sodium biphosphate with a bicarbonate and a medicinal agent, carbonate is a pleasant vehicle and lessens the bitter and salt taste of salts

properties of gelatin

soft gelatin advantages

effervescent powders

advantages of powders

effervescent powders

single doses of the powdered drug mixture individually enclosed in paper, cellophane, or metallic foil wrappers or packets, potent to require premeasured doses

dusting powders

bulk powders

micrometrics

divided powders

divided powders

_______ contain one water molecule that acts as binder in fusion method for making effervescent granules

Tartaric Acid

Benzoic Acid

All of the above

Citric Acid

Citric acid

Methods of granules formation EXCEPT

none

Fusion method

Wet method

Spatulation

Spatulation

Comminution

- Intended to be constituted into solutions or suspensions

- Reduction of particle size of solid substances to a finer state

- Bitter taste, moisture sensitive

- Dispensed in bulk quantities for non potent drugs

Reduction of particle size of solid substances to a finer state

Granule

Agglomerates of powdered material

Mills and pulverizers (FitzMill)

Citric acid and lactic acid

Mixing of 2+powders

Agglomerates of powdered material

disadvantages of powders and granules

- reduction of particle size of solid substances to a finer state

- they are intended to be reconstituted into solutions or suspensions

- antibiotics: amoxil, reflex, biaxin

- bitter taste, moisture sensitive, difficult to pack specially divided powders

bitter taste, moisture sensitive, difficult to pack specially divided powders

water dissolves a portion of powder mixture and thus acts as

lubricating agent

binding agent

antioxidant

wetting agent

binding agent

simple powder

mixture of finely divided solids in dry form single chemical substance in powder form

sticky mixture, difficult to granulate

oral and injectable powders for reconstitution

single chemical substance in powder form

Many unstable drugs are dispensed as oral or parenteral powders for reconstitution

TRUE FALSE

TRUE

The ration of the mixture of citric acid and tartaric acid is___

1:2

The following are true for spatulation method EXCEPT

- Blending small amount by spatula on sheet of paper or ointment tile

- Not suitable for large quantities of powder

- Can be used to mix eutectic mixtures

- It is suitable for potent substances

- None

It is suitable for potent substances

Powders disperse and dissolve more readily than compacted dosage forms because

They contain disintegrants

They are better lubricated

They have a greater surface area

They flow better

They have a greater surface area

Which of the following products are not classified as dispensed powder and granules?

Losenges

Insufflation

Douche

Dentrifice

Lozenges

Which is a major advantage of powders and granules?

they can mask unpleasant tastes

They are more stable than liquid preparations Bulk powders is easily carried by patients

They are good for dispensing hygroscopic and deliquescent drugs

They are more stable than liquid preparations

Which blending method is best suited for mixing powders of unequal quantities to best distribute a small amount of a very potent drug throughout a powder mix?

Granulation

Geometrid dilution

Levigation

Trituration

Geometric dilution

The gas evolved when effervescent powders dissolve in water is

Carbon dioxide

Packing divided powders in parchment paper is not suited for drugs that are

Coarse

Anhydrous

Very fine

hygroscopic

hygroscopic

The process of dissolving the gummy material in a solvent and then spread out on a pill tile to allow the solvent to evaporate leaving a thin film of the material on which the other ointment ingredients are spread.

Levigation

Trituration

Geometric dilution

Fusion

Pulverization by intervention

Pulverization by intervention

A method where the potent drug is placed with an equal volume of the diluent in a mortar and is mixed thoroughly by trituration. A second volume of diluent equal to the mixture is added and the trituration is repeated. This process is continued until all of the diluent has been added.

Levigation

Geometric dilution

Alligation

Eutexia

Aliquot

Geometric dilution

When powders are wetted, allowed to dry, and ground into coarse pieces, the resulting medication dosage form is

aerosols

all

cream

ointments

granules

granules

Methods of determining particle size

sedimentation

laser holography

microscopy

all

none

all

The ideal excipient for the preparation of chewable tablets containing moisture sensitive drug

- Lactose

- Mannitol

- Xylitol

- Dextrose

- Saccharin sodium

Mannitol

The following are used tablet formulation to reduce friction during tablet compression except

Magnesium stearate

None

Calcium stearate

Stearic acid

Mineral oil

None

Dose dumping is a problem encountered in

Controlled release products

All of the following impart satisfactory compression characteristics to the formulation of the tablet except:

- Diluents

- Sweetening agents

- Lubricants

- Binder

Sweetening agents

TRUE statement about the function of excipients used in tablet formulation EXCEPT

- Glidants promote the flow of the tablet granulation

- Diluents make up the desired bulk of the tablet formulation

- Binder promote granulation

- Lubricants help the patient to swallow the tablet

Lubricants help the patient to swallow the tablet

The principal factor that makes enteric coated tablets unpredictable in drug therapy is

- Varying thickness of the coating

- Premature in releaser of the drug

- Failure to release the drug

- State of the health of the patient

Failure to release the drug

Which of the following is not used as a binder for tablet

- Liquid

- Glucose

- Gelatin

- Starch

- Talc

Talc (glidant)

Type of tablet coating where the first coat is shellac is

Enteric coating

it is a common lubricant for tablets

Magnesium stearate

drugs that are destroyed by gastric acid or those that irritate the gastric mucosa are usually formulated as

- Chewable tablet

- Enteric coated tablets

- External preparation

- Capsules

Enteric coated tablets

This is used as binder, diluents and disintegrant for tablet

- Starch

- Magnesium Stearate

- Kaolin

- Talc

Starch

Tablet dosage form not requiring disintegration

- Sustained release

- Film coated

- Chewable

- Enteric coated

Chewable

The following are characteristics of pills except

- Adhesive

- Firm

- Chewable

- Plasticity property

Chewable

Type of coating for tables consisting of a thin of water insoluble polymeric substances is

Film coated

Unit-dose packaging for tablets or capsules is exemplified by;

I. strip packaging

II. blister pack

III, wide-mouthed bottles

I and II

Flavoring agents are usually added to:

I. Buccal tablets

II. Film-coated Tablets

III. Chewable Tablets

I and III are correct

Uncoated, bullet- or ovoid-shaped tablets intended for localized effect;

- Multiple compressed tablet

- Sugar-coated tablet

- Vaginal tablet

- Effervescent tablet

Vaginal tablet

Which method of tablet manufacture can be used to combine two incompatible substances in the same tablet:

- Multilayer compression

- Enteric coating

- Film coating

- Sugarcoating

Multilayer compression

To protect drugs from decomposition from moisture, tablets are co-packaged with:

- Dessicant package

- Aluminum foil

- Cotton wool

- Fumed silica

Desiccant package