chapter 37 - qualitative disorders of platelets & vasculature

bleeding into joints (hemarthroses)

clinical presentation of platelet-related bleeding may include all except

• bruising

• nosebleeds

• gastrointestinal bleeding

• bleeding to joints (hemarthroses)

loss on gpIIb/IIIa expression

glanzmann thrombasthenia results from defect in

Bernard-Soulier syndrome

ristocetin-induced platelet aggregation can be used in the diagnosis of which of the ff

storage pool defects

most common of the hereditary platelet function defects

altered expression of phospholipids on the platelet membrane

reduction in thrombin generation in px with Scott syndrome results from

decreased numbers of α-granules & dense granules

impaired platelet function in myeloproliferative neoplasms may result from

impaired membrane activation owing to protein coating

platelet defect associated with increased levels of para-proteins is

nitric oxide

in uremia, platelet function is impaired by higher than normal levels of

anti-gpIIb/IIIa antibodies

thrombocytopenia associated with the use of cardiopulmonary bypass is NOT caused by

• anti-gpIIb/IIIa antibodies

• hemodilution

• platelet binding to bypass circuitry

• platelet consumption associated with normal postsurgical hemostatic activity

blocking synthesis of thromboxane A₂

aspirin inhibits platelet function by

direct binding to gpIIa/IIIa

mechanism of antiplatelet drugs targeting gpIIb/IIIa function is

Ehlers-Danlos syndrome

congenital vascular disorder