End of Rotation Drugs

carisoprodol

Soma, Vanadom

Class: Muscle relaxant

Indication: musculoskeletal disorders

Common: dizziness, somnolence, headache

Serious: seizure, substance dependence, withdrawal symptoms

cyclobenzaprine

Flexeril

Class: Muscle relaxant

Indication: muscle spasms, fibromyalgia

Common: dry mouth, dizziness, drowsiness, fatigue, constipation

Serious: cardiac arrest, serotonin syndrome, respiratory depression

methocarbamol

Robaxin

Class: Muscle relaxant

Indication: musculoskeletal pain, muscle spasms

Common: dizziness, drowsiness, N/V, blurred vision, rash

Serious: anaphylaxis, seizure, jaundice

baclofen

Lioresal, Ozobax, Fleqsuvy

Class: Centrally acting skeletal muscle relaxant

Indication: muscle spasticity/spasms, alcohol use disorder

Common: somnolence, muscle weakness/fatigue, headache, dizziness, N/V/D

Serious: GI hemorrhage, withdrawal, severe drowsiness/confusion/hallucination s

tizanidine

Zanaflex

Class: Centrally Acting Skeletal Muscle Relaxant, α2-Agonist

Indication: muscle spasticity/spasms

Common: fatigue, dry mouth, dizziness, constipation, N/V

Serious: liver injury, hypotension

celecoxib

Celebrex

Class: NSAID

Indication: acute pain, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, primary dysmenorrhea

Common: hypotension, N/D, headache

Serious: heart attack, Stevens-Johnson syndrome, GI bleeding/ulceration, anaphylaxis, kidney injury/failure, liver failure

ibuprofen

Motrin

Class: NSAID

Indication: pain, headache, fever, osteoarthritis, rheumatoid arthritis

Common: N/V, dizziness, headache, heartburn

Serious: Reye’s syndrome, GI ulceration/bleeding, liver/kidney injury, Stevens-Johnson syndrome

indomethacin

Indocin, Tivorbex

Class: NSAID

Indication: acute pain, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis

Common: N/V/D, abdominal pain, constipation, headache, dizziness, drowsiness

Serious: heart attack, GI bleeding/ulceration, liver or kidney injury/failure

meloxicam

Mobic

Class: NSAID

Indication: osteoarthritis, rheumatoid arthritis, gout

Common: N/V/D, constipation, headache, dizziness, edema, upper respiratory infection

Serious: increase risk of HA and stroke, GI ulceration/bleeding, liver/kidney injury, anaphylaxis, Stevens-Johnson syndrome

naproxen

Naprosyn, Aleve

Class: NSAID

Indication: pain, fever, osteoarthritis, rheumatoid arthritis, gout

Common: stomach pain, tinnitus, N/D, constipation, dizziness, rash

Serious: hypertension, increased risk of HA/stroke, GI ulceration/bleeding, jaundice, kidney injury/failure

hydrocodone

Norco, Lorcet, Vicodin

Class: Opioid analgesic (CII)

Indication: moderate-severe pain

Common: N/V, constipation, dry mouth, headache, drowsiness, UTI

Serious: respiratory depression, serotonin syndrome, liver injury, hypotension, Stevens-Johnson syndrome, seizure

codeine

Tylenol with codeine

Class: Opioid analgesic (CII for tablets, CV for liquid)

Indication: mild-moderate pain

Common: constipation, N/V, drowsiness, lightheadedness

Serious: respiratory depression, cardiac arrest, serotonin syndrome

morphine

MS Contin, Avinza, Kadian

Class: Opioid analgesic (CII)

Indication: moderate-severe acute/chronic pain

Common: constipation, drowsiness, dry mouth, N/V

Serious: respiratory depression, anaphylaxis, cardiac arrest, substance dependence or withdrawal

oxycodone

OxyContin

Class: Opioid analgesic (CII)

Indication: moderate-severe chronic pain

Common: dizziness, drowsiness, constipation, dry mouth, sweating, pruritis

Serious: respiratory depression, anaphylaxis, serotonin syndrome

tramadol

Ultram, ConZip, Qdolo

Class: Opioid analgesic (CIV)

Indication: moderate-moderately severe chronic pain

Common: lightheadedness, drowsiness, N/V, constipation, dry mouth

Serious: seizure, serotonin syndrome, respiratory depression, hypersensitivity reaction, substance dependence/withdrawal

lidocaine (topical)

Lidoderm

Class: Local anesthetic (pain, analgesic agent)

Indication: postherpetic neuralgia (nerve pain from shingles), localized pain

Common: skin irritation, erythema

Serious: anaphylaxis (allergic reaction), methemoglobinemia

gabapentin

Neurontin, Gralise

Class: Gamma aminobutyric acid (GABA) analog, Anticonvulsant

(neurologic agent)

Indication: postherpetic neuralgia, seizures, fibromyalgia, restless leg syndrome, neuropathic pain

Common: blurry vision, dizziness, drowsiness, peripheral edema, N/V, dry mouth

Serious: respiratory depression, Stevens-Johnson syndrome, anaphylaxis, suicidal ideation/tendencies

pregablin

Lyrica

Class: Anticonvulsant, GABA analog (CV)

Indication: fibromyalgia, neuropathic pain, seizures, restless leg syndrome

Common: weight gain, peripheral edema, constipation, dry mouth, headache, fatigue

Serious: respiratory depression, suicidal ideation/tendencies

benazepril

Lotensin

Class: ACE inhibitor, Antihypertensive

Indication: HTN, heart failure, CKD

Common: dry cough, headache, dizziness, fatigue

Serious: angioedema, hyperkalemia, kidney injury, hypotension

amlodipine

Norvasc

Class: Calcium channel blocker

Indication: angina, HTN, Raynaud phenomenon

Common: edema, abdominal pain, dizziness, drowsiness, flushing

Serious: allergic reaction, HA, hypotension

nifedipine

Procardia XL, Adalat CC

Class: Calcium channel blocker

Indication: HTN, angina

Common: headache, flushing, dizziness, constipation, fatigue, peripheral edema

Serious: hypotension, HA, GI ulceration/obstruction

verapamil

Calan SR

Class: Calcium channel blocker

Indication: HTN, angina, atrial fibrillation, tachycardia

Common: constipation, lightheadedness, headache, nausea

Serious: heart failure, jaundice, pulmonary edema

carvedilol

Coreg, Coreg CR

Class: α/β-Adrenergic Blocker

Indication: heart failure w/ reduced ejection fraction, HTN

Common: bradycardia, hypotension, dizziness, N/V/D, fatigue, insomnia

Serious: bronchospasm, hypoglycemia, kidney/liver injury

clonidine

Catapres, Kapvay

Class: α/β-Adrenergic Blocker

Indication: HTN, ADHD

Common: dry mouth, drowziness, dizziness, constipation, headache

Serious: withdrawal symptoms, bradycardia, hypotension

labetalol

Normodyne

Class: α/β-Adrenergic Blocker

Indication: HTN

Common: fatigue, N/V, headache, lightheadedness

Serious: bradycardia, bronchospasm, hypoglycemia, withdrawal symptoms

metoprolol

Lopressor, Toprol XL

Class: β-Adrenergic Blocker

Indication: angina, heart failure, HTN, HA

Common: N/D, fatigue, dizziness, insomnia, depression

Serious: bradycardia, bronchospasm, hypoglycemia

atenolol

Tenormin

Class: β-Adrenergic Blocker

Indication: angina, HTN, HA

Common: hypotension, fatigue, depression, dizziness, N/D, constipation

Serious: bradycardia, bronchospasm, hypoglycemia, withdrawal symptoms

bisoprolol

Zebeta

Class: Cardioselective β-Adrenergic Blocker

Indication: HTN, angina, atrial fibrillation, heart failure, ventricular arrhythmia

Common: fatigue, upper respiratory infection, headache, dizziness, N/V/D

Serious: bronchospasm, bradycardia, hypoglycemia, heart failure, hypotension

clopidogrel

Plavix

Class: Antiplatelet agent

Indication: reduce risk of HA and stroke

Common: minor bleeding (<10 min), bruising, headache, dizziness, abdominal pain

Serious: major bleeding (>10 min), hypersensitivity reaction, thrombotic thrombocytopenic purpura (TTP)

dabigatran

Pradaxa

Class: Anticoagulant

Indication: stroke prevention, DVT and blood clot prevention, venous thromboembolism prophylaxis

Common: minor bleeding, bruising, abdominal pain, N/V/D

Serious: HA, major bleeding, GI ulceration/bleeding, anaphylaxis

warfarin

Coumadin, Jantoven

Class: Anticoagulant

Indication: HA, atrial fibrillation, pulmonary embolism, venous thromboembolism

Common: alopecia, minor bleeding, N/V/D, stomach pain, bruising

Serious: major bleeding, vasculitis, skin necrosis, “purple toe” syndrome, liver damage

rivaroxaban

Xarelto

Class: Anticoagulant

Indication: atrial fibrillation, coronary artery disease, thromboprophylaxis cardiovascular events

Common: minor bleeding, abdominal pain, dizziness, fatigue

Serious: major bleeding, spinal/epidural hematoma, liver injury

digoxin

Digitek, Digox, Lanoxin

Class: Antiarrhythmic

Indication: atrial fibrillation, heart failure, supraventricular tachycardia

Common:N/V/D, dizziness, headache, blurred vision

Serious: digoxin toxicity, hypersensitivity reaction, cardiac dysrhythmia

isosorbide mononitrate

Imdur

Class: Antianginal

Indication: angina, heart disease

Common: dizziness, headache, flushing

Serious: hypotension, bradycardia, methemoglobinemia

nitroglycerin

Nitrostat, Nitro-Dur, Minitran, Nitro-Bid

Class: Antianginal

Indication: angina

Common: headache, dizziness, flushing, N/V

Serious: hypotension, cardiac dysrhythmia, allergic reaction

chlorthalidone

Hygroton, Thalitone

Class: Thiazide diuretic

Indication: edema/general volume overload, HTN

Common: hypotension, N/V/D, sun sensitivity, increase urination

Serious: myopia, hypokalemia, hypercalceima, hyponatermia, gout, hypersensitivity reactions

hydrochlorothiazide

Microzide

Class: Thiazide diuretic

Indication: edema/general volume overload, HTN

Common: sun sensitivity, hypotension, N/D, constipation, headache, hyperglycemia

Serious: hypokalemia, hypercalcemia, hyponatremia, gout, myopia, hypersensitivity reactions

triamterene/hydrochlorothiazide

Maxzide, Dyazide

Class: Thiazide diuretic

Indication: HTN, edema

Common: upset stomach, hypotension, blurred vision, N/V/D

Serious: electrolyte imbalance, hyperglycemia, myopia, liver damage

furosemide

Lasix

Class: Loop diuretic

Indication: edema/volume overload, HTN, heart failure, ascites

Common: sun sensitivity, increase urination, hypotension, N/V/D, constipation, headache

Serious: kidney injury, electrolyte imbalance, hypersensitivity reactions, ototoxicity

hydralazine

Apresoline

Class: Antihypertensive

Indication: HTN, heart failure

Common: tachycardia, headache, N/V/D, constipation, flushing, dizziness

Serious: lupus-like syndrome, peripheral neuropathy, angina, hypotension

irbesartan

Avapro

Class: Angiotensin II receptor blocker, Antihypertensive

Indication: HTN, CKD, diabetic neuropathy

Common: hypotension, diarrhea, fatigue, heartburn

Serious: hyperkalemia, kidney injury/failure, hypersensitivity reaction

olmesartan

Benicar

Class: Angiotensin II receptor blocker, Antihypertensive

Indication: HTN, CKD

Common: dizziness, headache, upper respiratory infection, diarrhea, back pain

Serious: chest pain, hypotension, kidney injury/failure

valsartan

Diovan

Class: Angiotensin II receptor blocker, Antihypertensive

Indication: heart failure, HTN, post-MI, CKD

Common: hypotension, fatigue, dry cough, N/D, abdominal pain, headache

Serious: kidney injury/failure, angioedema, hyperkalemia

spironolactone

Aldactone, CaroSpir

Class: Aldosterone receptor agonist, Antihypertensive, Diuretic

Indication: heart failure, HTN, acites, primary hyperaldosteronism

Common: N/V/D, leg cramps, irregular menstrual cycle/postmenopausal bleeding, reduced sex drive, erectile dysfunction, fatigue, dizziness, headache

Serious: gynecomastia, hyperkalemia, hyponatremia, Stevens-Johnson syndrome, kidney injury/failure

ezetimibe

Zetia

Class: Antihyperlipidemic

Indication: hyperlipidemia, hypercholesterolemia

Common: upper respiratory tract infection, headache, dizziness, joint/muscle pain, fatigue, diarrhea

Serious: rhabdomyolysis, liver injury, allergic reaction

pravastatin

Pravachol

Class: HMG-CoA reductase inhibitor, Anihyperlipidemic

Indication: hypercholesterolemia, prevention/treatment of coronary heart disease (CHD)

Common: muscle pain/weakness, N/V/D, constipation, headache, upper respiratory tract infection

Serious: liver failure, rhabdomyolysis, T2DM

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