Forum revision 7/7/25 heart failure

Name the loop diuretics used in the treatment of heart failure..

Furosemide and Bumetanide

Name the Aldosterone Antagonists used in treatment of heart failure…

Spironolactone - side effects breast enlargement or menstrual irregularities

Eplerenone - fewer side effects compared to spironolactone

Regular monitoring of what is crucial with aldosterone antagonists ?

potassium and creatinine levels -due to the risk of hyperkalemia

General Side effects of Aldosterone Antagonists?

hyperkalemia, dizziness, nausea, and muscle cramps.

Mode of action of Aldosterone antagonists?

Blocks action of Aldosterone so sodium and water can be excreted rather than retained, this lowers BP and reduces fluid overload

Interacts with warfarin

NSAIDS, Miconazole, St Johns wort - increase anticoagulant effect

Alcohol & green food - decreases anticoagulant effect

Thyroid tests required for which AF drug?

amiodarone

Has a Long half life

amiodarone

causes photosensitivity and corneal deposits (changes to vision - reversible)

Amiodarone

Side effects of amiodarone

Nausea, GI, headache, dark urine (liver toxic) photosensitivity, corneal deposits

side effects digoxin

nausea, vomiting, visual disturbances