Transfusion medicine

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Last updated 8:14 AM on 7/27/26
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61 Terms

1
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Q: What are antigens?

A: Markers found on the surface of red blood cells (RBCs).

2
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Q: What are antibodies?

A: Immune proteins found in plasma that attack foreign antigens.

3
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Q: Where are ABO antigens located?

A: On the surface of red blood cells.

4
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Q: Where are ABO antibodies located?

A: In the plasma.

5
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Q: What determines a person's ABO blood type?

A: The antigens present on the surface of their RBCs.

6
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Q: What determines whether someone is Rh positive or Rh negative?

A: The presence or absence of the D antigen.

7
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Q: What antigen is present in Rh positive blood?

A: The D antigen.

8
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Q: What antigen is absent in Rh negative blood?

A: The D antigen.

9
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Q: Are Rh negative people born with Anti D antibodies?

A: No.

10
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Q: When do Rh negative people develop Anti D antibodies?

A: After exposure to Rh positive blood.

11
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Q: How can an Rh negative person become exposed to Rh positive blood?

A: Through transfusion or pregnancy.

12
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Q: What antigen is present on Type A blood?

A: A antigen.

13
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Q: What antibody is present in Type A plasma?

A: Anti B.

14
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Q: What antigen is present on Type B blood?

A: B antigen.

15
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Q: What antibody is present in Type B plasma?

A: Anti A.

16
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Q: What antigens are present on Type AB blood?

A: A and B antigens.

17
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Q: What antibodies are present in Type AB plasma?

A: None.

18
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Q: What antigens are present on Type O blood?

A: None.

19
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Q: What antibodies are present in Type O plasma?

A: Anti A and Anti B.

20
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Q: Which blood type is the universal RBC donor?

A: O negative (O).

21
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Q: Why is O negative the universal RBC donor?

A: It has no A, B, or Rh antigens.

22
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Q: Which blood type is the universal RBC recipient?

A: AB positive (AB+).

23
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Q: Why is AB

positive the universal RBC recipient?

24
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Q: What blood type is used in emergencies when the patient's blood type is unknown?

A: O negative.

25
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Q: Why is O negative blood safe for emergency transfusions?

A: It has no RBC antigens that can react with recipient antibodies.

26
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Q: What is agglutination?

A: Clumping of red blood cells caused by antibodies binding to matching antigens.

27
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Q: What causes agglutination?

A: Matching antibodies reacting with corresponding antigens.

28
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Q: Why is agglutination dangerous?

A: It can block blood vessels and destroy RBCs.

29
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Q: What is hemolysis?

A: The destruction of red blood cells.

30
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Q: What can happen if incompatible blood is transfused?

A: Agglutination and hemolysis.

31
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Q: How much blood is collected during a standard donation?

A: 450–500 mL.

32
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Q: How long can donated blood be stored?

A: 42 days.

33
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Q: What day does donated blood expire?

A: Day 43.

34
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Q: What preservative is used in donated blood?

A: Citrate Phosphate Dextrose (CPD).

35
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Q: What is the function of CPD?

A: It preserves RBCs during storage.

36
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Q: Which blood product is used to treat anemia?

A: Packed Red Blood Cells (PRBCs).

37
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Q: Which blood product is used to treat coagulation disorders?

A: Fresh Frozen Plasma (FFP).

38
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Q: Which blood product is used to treat hemophilia?

A: Clotting factor concentrate.

39
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Q: Which blood product is used for massive blood loss?

A: Whole blood.

40
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Q: What is the primary purpose of Fresh Frozen Plasma (FFP)?

A: To replace clotting factors.

41
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Q: What does FFP contain?

A: Clotting factors.

42
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Q: What is an autologous blood donation?

A: A patient donates blood for their own future use.

43
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Q: When is an autologous donation usually performed?

A: Before planned surgery.

44
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Q: What is the biggest advantage of an autologous donation?

A: No risk of blood incompatibility.

45
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Q: How are platelets stored?

A: At room temperature.

46
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Q: Why must platelets be continuously agitated?

A: To prevent clumping and maintain function.

47
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Q: What happens if platelets are not continuously agitated?

A: They clump and become unusable.

48
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Q: What condition occurs when an Rh

negative mother carries an Rh

49
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Q: What blood type must the mother be for HDN to occur?

A: Rh negative.

50
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Q: What blood type must the baby be for HDN to occur?

A: Rh positive.

51
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Q: Which pregnancy usually sensitizes the Rh negative mother?

A: The first Rh positive pregnancy.

52
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Q: Which pregnancy is at greatest risk for HDN?

A: Subsequent Rh positive pregnancies.

53
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Q: What happens during maternal sensitization?

A: The mother develops Anti D antibodies after exposure to Rh positive fetal blood.

54
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Q: What are the effects of HDN on the baby?

A: Fetal anemia, elevated bilirubin (jaundice), and red blood cell destruction.

55
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Q: What medication prevents HDN?

A: RhoGAM.

56
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Q: Who receives RhoGAM?

A: Rh negative mothers.

57
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Q: What is the purpose of RhoGAM?

A: To prevent the formation of Anti D antibodies.

58
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Q: What does RhoGAM protect?

A: Future Rh positive pregnancies.

59
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Q: What is the most common blood type?

A: O positive (O+).

60
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Q: What is the second most common blood type?

A: A positive.

61
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Q: What is the Rh factor rule?

A: Rh negative people are not born with AntiD antibodies; they develop them only after exposure to Rh positive blood.