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Q: What are antigens?
A: Markers found on the surface of red blood cells (RBCs).
Q: What are antibodies?
A: Immune proteins found in plasma that attack foreign antigens.
Q: Where are ABO antigens located?
A: On the surface of red blood cells.
Q: Where are ABO antibodies located?
A: In the plasma.
Q: What determines a person's ABO blood type?
A: The antigens present on the surface of their RBCs.
Q: What determines whether someone is Rh positive or Rh negative?
A: The presence or absence of the D antigen.
Q: What antigen is present in Rh positive blood?
A: The D antigen.
Q: What antigen is absent in Rh negative blood?
A: The D antigen.
Q: Are Rh negative people born with Anti D antibodies?
A: No.
Q: When do Rh negative people develop Anti D antibodies?
A: After exposure to Rh positive blood.
Q: How can an Rh negative person become exposed to Rh positive blood?
A: Through transfusion or pregnancy.
Q: What antigen is present on Type A blood?
A: A antigen.
Q: What antibody is present in Type A plasma?
A: Anti B.
Q: What antigen is present on Type B blood?
A: B antigen.
Q: What antibody is present in Type B plasma?
A: Anti A.
Q: What antigens are present on Type AB blood?
A: A and B antigens.
Q: What antibodies are present in Type AB plasma?
A: None.
Q: What antigens are present on Type O blood?
A: None.
Q: What antibodies are present in Type O plasma?
A: Anti A and Anti B.
Q: Which blood type is the universal RBC donor?
A: O negative (O).
Q: Why is O negative the universal RBC donor?
A: It has no A, B, or Rh antigens.
Q: Which blood type is the universal RBC recipient?
A: AB positive (AB+).
Q: Why is AB
positive the universal RBC recipient?
Q: What blood type is used in emergencies when the patient's blood type is unknown?
A: O negative.
Q: Why is O negative blood safe for emergency transfusions?
A: It has no RBC antigens that can react with recipient antibodies.
Q: What is agglutination?
A: Clumping of red blood cells caused by antibodies binding to matching antigens.
Q: What causes agglutination?
A: Matching antibodies reacting with corresponding antigens.
Q: Why is agglutination dangerous?
A: It can block blood vessels and destroy RBCs.
Q: What is hemolysis?
A: The destruction of red blood cells.
Q: What can happen if incompatible blood is transfused?
A: Agglutination and hemolysis.
Q: How much blood is collected during a standard donation?
A: 450–500 mL.
Q: How long can donated blood be stored?
A: 42 days.
Q: What day does donated blood expire?
A: Day 43.
Q: What preservative is used in donated blood?
A: Citrate Phosphate Dextrose (CPD).
Q: What is the function of CPD?
A: It preserves RBCs during storage.
Q: Which blood product is used to treat anemia?
A: Packed Red Blood Cells (PRBCs).
Q: Which blood product is used to treat coagulation disorders?
A: Fresh Frozen Plasma (FFP).
Q: Which blood product is used to treat hemophilia?
A: Clotting factor concentrate.
Q: Which blood product is used for massive blood loss?
A: Whole blood.
Q: What is the primary purpose of Fresh Frozen Plasma (FFP)?
A: To replace clotting factors.
Q: What does FFP contain?
A: Clotting factors.
Q: What is an autologous blood donation?
A: A patient donates blood for their own future use.
Q: When is an autologous donation usually performed?
A: Before planned surgery.
Q: What is the biggest advantage of an autologous donation?
A: No risk of blood incompatibility.
Q: How are platelets stored?
A: At room temperature.
Q: Why must platelets be continuously agitated?
A: To prevent clumping and maintain function.
Q: What happens if platelets are not continuously agitated?
A: They clump and become unusable.
Q: What condition occurs when an Rh
negative mother carries an Rh
Q: What blood type must the mother be for HDN to occur?
A: Rh negative.
Q: What blood type must the baby be for HDN to occur?
A: Rh positive.
Q: Which pregnancy usually sensitizes the Rh negative mother?
A: The first Rh positive pregnancy.
Q: Which pregnancy is at greatest risk for HDN?
A: Subsequent Rh positive pregnancies.
Q: What happens during maternal sensitization?
A: The mother develops Anti D antibodies after exposure to Rh positive fetal blood.
Q: What are the effects of HDN on the baby?
A: Fetal anemia, elevated bilirubin (jaundice), and red blood cell destruction.
Q: What medication prevents HDN?
A: RhoGAM.
Q: Who receives RhoGAM?
A: Rh negative mothers.
Q: What is the purpose of RhoGAM?
A: To prevent the formation of Anti D antibodies.
Q: What does RhoGAM protect?
A: Future Rh positive pregnancies.
Q: What is the most common blood type?
A: O positive (O+).
Q: What is the second most common blood type?
A: A positive.
Q: What is the Rh factor rule?
A: Rh negative people are not born with AntiD antibodies; they develop them only after exposure to Rh positive blood.