COAG Rodak Chp. 4, 5, 10 book chapters

The organelle involved in packing and trafficking of cellular products is the

Golgi apparatus

The glycocalyx is composed of membrane:

Glycoproteins and glycolipids

The control center of the cell is the

nucleus

the nucleus is composed largely of

DNA

The site of protein synthesis is the

Ribosomes

The shape of a cell is maintained by which of the following

microtubules

Functions of the cell membrane include all of the following EXCEPT

Lipid production and oxidation

Functions of the cell membrane includes these three main functions

regulation of molecules entering or leaving the cell

receptor recognition of extracellular signals

maintenance of electrochemical gradients

the energy source for cells is the

mitochondria

ribosomes are synthesized by the

nucleolus

Euchromatin functions as the

transcriptionally active DNA

The sodium potassium ATPase in the red blood cell membrane is an example of

active transport

True or false: the binding of leggings to membrane receptors is not able to induce change in gene expression

false

Are these three statements true or false?

Membrane permeable ligands can directly bind to intracellular receptors

A transmembrane receptor can transmit a signal into the cell through its cytoplasmic domain when ligand binds it's extracellular domain

The binding of membrane receptors to fixed ligands such as extracellular matrix can transmit intracellular signals

True

The cell cycle is regulated by

Cyclins and cyclin dependent kinases

The transition from G1 to S stage of the cell cycle is regulated by

Cyclin E/CDK2 complex

Apoptosis is morphologically identified by

Nuclear condensation and fragmentation

Necrosis is morphologically identified by

nucleus breakdown

Regulation of the hematopoietic, micro environment is provided by the

stromal cells and growth factors

The process of formation and development of blood cells is termed

Hematopoiesis

During the second trimester of fetal development, the primary site of blood cell production is the

Liver

Which of the following organs is responsible for the maturation of T lymphocytes and regulation of their expression of CD4 in CD8

Thymus

The best source of active bone marrow for a 20 year-old would be

Iliac Crest

Physiological program cell death is termed

Apoptosis

Which organ is the site of sequestration of platelets

Spleen

Which one of the following morphologic changes occurs during normal blood cell maturation

Condensation of nuclear chromatin

Which one of the following cells is a product of the common lymphoid progenitor?

T lymphocyte

What growth factor is produced in the kidneys and is used to treat anemia associated with kidney disease

EPO

Which one of the following cytokinesis is required very early in the differentiation of a hematopoietic stem cell

FLT3 ligand

When a patient has severe anemia, and the bone marrow is unable to effectively produce RBC's to meet the increased demand one of the bodies responses is

extramedullary hematopoiesis in the liver and spleen

Hematopoietic stem cells produce all lineages of blood cells in sufficient quantities over the lifetime of an individual because they

have the ability of self renewal by asymmetric division

Neutrophils and monocytes are directly descendants of a common progenitor known as

GMP

The stage in neutrophilic development in which the nucleus is indented in a kidney bean shape and the cytoplasm has secondary granules that are lavender and color is the

metamyleocyte

Type two Myeloblasts are characterized by

the presence of fewer than 20 primary granules per cell

Which one of the following is a function of neutrophils?

nonspecific destruction of foreign organisms

Which of the following cells are important in immune regulation, allergic inflammation, and destruction of tissue invading helminths

eosinophils and basophils

basophils and mast cells have a high affinity surface receptors for which immunoglobulin

E

what cell is capable of differentiating into osteoclasts, macrophages, or dendritic cells

monocytes

macrophages aid in adaptive immunity by

degrading antigen and presenting it to lymphocytes

what is the final stage of B cell maturation after activation by antigen

plasma cell

which of the following is unique to B and T lymphocytes and occurs during their early development

Rearrangement of antigen receptor genes